All Mesalamine medications give me those symptoms and they continue to get worse until I stopped them - ASacol, LIalda, Rowasa, Canasa, Colazal, etc. I tried to continue but always got worse. HOWEVER, if I could have tolerated them they were helping to some degree with bleeding, cramping, etc. I felt just like I had the flu and got bad a couple of times so that I could barely get out of bed.
I will not/can not take mesalamine medications again - felt worse than the UC.