Rectal Hypersensitivity

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bbc
Veteran Member


Date Joined Mar 2008
Total Posts : 1580
   Posted 9/27/2009 9:17 PM (GMT -7)   
Anyone here familiar with this disorder and if IBD or its meds can cause it?
 
Thanks


Dx'd with moderate Pancolits 05/07 better with Pentasa and Cortifoam.
I also take Probiotics, Curcumin, Benefiber and cannot tolerate
artificial sweetners (never could even before UC).
 
 
UC Forum Co-Moderator
I am not a healthcare provider. I am offering support and guidance based upon my own conclusions and/or research. ALWAYS consult with a qualified healthcare provider.

Post Edited (bbc) : 9/27/2009 9:29:41 PM (GMT-6)


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 18194
   Posted 9/27/2009 11:41 PM (GMT -7)   
I'm familiar with it as far as living it, this is basically what my problem is (which I refer to as having urgency issues). I know that IBS can cause it...

Abstract:

Rectal hypersensitivity induced by repetitive rectal distention (RRD) is reported to be a response specific to patients with irritable bowel syndrome (IBS), and is not observed in healthy controls. We evaluated the rectal pain threshold (PT) and determined whether intravenous corticotropin-releasing factor (CRF) induces rectal hypersensitivity after RRD in healthy humans, that is, whether it mimics the response observed in IBS patients.

A double-blind placebo-controlled study design (CRF or vehicle) was used. In the first experiment, PT (mmHg) induced by ramp distention was measured by a barostat. Then CRF (100 µg, n = 5) or vehicle (n = 6) was injected intravenously (iv) followed by RRD, consisting of phasic distentions with sensory tracking, which lasted until the subjects had complained of pain six times. After RRD, PT was measured again. In another experiment, PT was measured, and then CRF (n = 5) or vehicle (n = 5) was injected iv. After 45 min, ramp distention was again induced to determine PT.

In the placebo group, PT was not modified by RRD (before RRD, 33.0 ± 6.8; after RRD, 33.4 ± 4.5), while it was significantly reduced in the CRF-treated group (before RRD, 32.9 ± 9.0; after RRD, 26.1 ± 7.9, P < 0.05). On the other hand, CRF or vehicle without RRD did not alter PT (before iv-CRF, 35.2 ± 4.2; after iv-CRF, 35.3 ± 4.9; before iv-vehicle, 34.5 ± 7; after iv-vehicle, 35.5 ± 6.8).

These results indicate that CRF modifies rectal sensation in healthy humans and mimics an IBS-specific visceral response, suggesting the possible contribution of CRF to the pathogenesis of IBS.


And I have been DX with having IBS as well as crohn's colitis (CD affecting the colon) and I have to say that at the beginning when I got sick, I probably would have pooped myself had I not been able to get to a toilet in time BUT I was able to hold it in longer then, then it seems that around the time my GI suspected I also have IBS is when it was getting harder to hold it (and much shorter time span holding it in) so I don't know if it's also related to IBD only but like I said above, since being DX with IBS as well I find it much harder to hold it in (impossible actually) than I did when I first got sick with crohn's and I was flaring severely then too.  Plus, I don't even have D so I'm talking formed stools and I cannot hold them back (which shocked the heck out of me when I discovered this).
:)


bee propolis caps 500mg one cap twice/day
omegas 369 caps one cap twice/day
probiotics 10 billion cfu once/day
vitamins C-calcium ascorbate (easy on the gut) and vitamin A each once/day
Prodiem fibre supplement one cap before bed
I've also altered my diet (no junky stuff at all, processed, fast-foods, refined sugars, ect) and exercise regularly.
I went from 30+ bloody BM's/day with lots of lower back pain to an average of 5/day no bleeding no back pain and completely formed stools, still have severe urgency issues.
~~~~~~~~My bum is broken....there's a big crack down the middle of it! LOL :)~~~~~~~~


quincy
Elite Member


Date Joined May 2003
Total Posts : 25893
   Posted 9/28/2009 12:45 AM (GMT -7)   
My time to go is in the morning, and I pretty much go when I have the urge. But once it's starting to make its way into the rectum, I have to go NOW. I don't normally have the urge during the day, however....
But if I'm flaring, that's a different thing.

bbc...are you talking about during any time or when you're flaring or once you have the urge you can't hold it at all?

Does the urge come quickly meaning you don't have any feelings that you have to go and then it's now?

Is it diarrhea you're having or more formed?

q
*Heather* Status: ...Asacol 3 twice daily; Salofalk enemas every 3rd night
~diagnosed January 1989 UC (proctosigmoiditis)
~UC meds: Asacol (3 @ 2x daily); Salofalk enemas nightly for flares & taper to maintenance 
~Bentylol (dicyclomine) 20mg as needed; Ranitidine (reflux);  Effexor XR 75mg(depression);  Pulmicort/Airomir (asthma) 
~vitamins/minerals/supplementsProbiotics....(RenewLife Ultimate Flora Critical Care + Primadophilus Reuteri). @ bedtime
~various digestive enzymes as needed
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!
 


Mitzo
Veteran Member


Date Joined Dec 2007
Total Posts : 536
   Posted 9/28/2009 5:13 AM (GMT -7)   
Same here - can't-hold-it urgency whether I am flaring or not, formed stools or not.
23 years of UC which started after quitting smoking. In and out of flares which are usually triggered by antibiotics. Latest issue is endless diarrhea without blood or mucous.
 
Currently off all meds and probiotics. Using grapefruit seed extract, iron supplement, calcium, L-glutamine and psyllium seed powder with good effect.

 


bbc
Veteran Member


Date Joined Mar 2008
Total Posts : 1580
   Posted 9/28/2009 11:29 AM (GMT -7)   
Hi Guys,

I do not mean urgency but when the rectal area nerves becomes hypersensitive to the touch making it very painful to have even a soft bm or even sit down...I am not flaring (just had a scope) but my anal/rectal area burns after each bm and stay that way all day...I was told I have levator ani and am going for pelvic floor PT starting tomorrow. This condition is very very painful.
Dx'd with moderate Pancolits 05/07 better with Pentasa and Cortifoam.
I also take Probiotics, Curcumin, Benefiber and cannot tolerate
artificial sweetners (never could even before UC).
 
 
UC Forum Co-Moderator
I am not a healthcare provider. I am offering support and guidance based upon my own conclusions and/or research. ALWAYS consult with a qualified healthcare provider.


Eva Lou
Veteran Member


Date Joined Sep 2006
Total Posts : 3202
   Posted 9/28/2009 11:50 AM (GMT -7)   
that sucks- I thought you just meant that urge, not actual pain. For me, that's about all I have- the sudden urge, with solid stools. When I have to go, I have maybe a  window of 1 minute to get somewhere. But, I know about 2-3 minutes prior to the unbearable urge that I'm going to have to find a toilet now! So it's usually ok. I wonder what they do for pelvic floor PT, kegels?
diagnosed with UC '02
meds-
Asacol- 8 tabs/day
Remicade-10mgs/kg- since 4/07
Imuran- 150mgs/day
various probiotics
Fiber supplement
 
 
 


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 18194
   Posted 9/28/2009 12:17 PM (GMT -7)   
It's funny that you mentioned kegal exercises Eva Lou...I found when I was doing them it seemed to cause acutal pain in my rectom and general groin area and I'd get these cramps in those areas and during bowel movements it was excrutiation so I stopped doing kegals and no longer have had cramping/pain issues in those areas.

:)
bee propolis caps 500mg one cap twice/day
omegas 369 caps one cap twice/day
probiotics 10 billion cfu once/day
vitamins C-calcium ascorbate (easy on the gut) and vitamin A each once/day
Prodiem fibre supplement one cap before bed
I've also altered my diet (no junky stuff at all, processed, fast-foods, refined sugars, ect) and exercise regularly.
I went from 30+ bloody BM's/day with lots of lower back pain to an average of 5/day no bleeding no back pain and completely formed stools, still have severe urgency issues.
~~~~~~~~My bum is broken....there's a big crack down the middle of it! LOL :)~~~~~~~~

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