Yes, I have two recommendations. The first is that you get her on the site www.j-pouch.org There are over 6,000 jpouchers on that site that have experienced all kinds of difficulties and will have tips/advice for your sister. I would also question the advice of the surgeon who lets an incision problem continue to this point. She might want to change doctors for future problems and can also get great CR and GI recommendations from the jpouch site. Once treated for cuffitis she should be able to manage that quite successfully with either the suppositories (short term) and oral medication (long term). It's probably overwhelming at this point to think it will get better but it will if she gets treatment from the right doctors.