balsalazide versus mesalamine

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KrissyUC
Veteran Member


Date Joined Feb 2010
Total Posts : 971
   Posted 2/24/2010 11:31 AM (GMT -7)   
What is the diff here?
And for those of you who are Canadian, what is the brand name balsalazide called here?
 
I just read that it is better than mesalamine for inducing remission.
UC since Aug 2006
Been a constant battle since Feb 08 after the birth of my son
HUMIRA JUL2008- JAN 2010
Salofalk 9 pills a day
Salofalk Suppositories 1g each night at the moment
Fish oil, VSL, Vit D, Vit C, Vit B12 3x weekly Flax oil, reduced red meat, refined grains and dairy
physillium husks -1 cap with each meal
 
Current Status: 1-3 BM a day, would not consider this remission cuz of the urgency...


Judy2
Forum Moderator


Date Joined Mar 2003
Total Posts : 9646
   Posted 2/24/2010 11:38 AM (GMT -7)   
Mesalamine works better for some, Balsalazide for others. Here in the US Balsalazide brand name is Colazal. I don't know what it's called or if it's available in Canada.

basa0806
Veteran Member


Date Joined Feb 2005
Total Posts : 2103
   Posted 2/24/2010 12:33 PM (GMT -7)   
Colazal is weird for me. While I was flaring I switched from asacol to colazal and it made my symptoms worse so I went back to asacol. Then about a year and a half ago I was have issues more frequently and my GI tried colazal again and I found it works better for me in remission than asacol.
I want to say that asacol is a straight mesalamine pill but colazal is a medication that breaks down into mesalamine in the colon. Don't quote me on that though...
Sam(antha)
21 year old college student diagnosed in March 2005
Remission since January/April 2006-->FOUR years!
Meds: 3 750mg Colazal 2x, 25mg Elavil, 75mg Effexor XR for GAD, ortho lo
"It is not the strongest speices that survives, nor the most intelligent that survives. It is the one that is most adaptable to change"
Charles Darwin


Red_34
Forum Moderator


Date Joined Apr 2004
Total Posts : 22185
   Posted 2/24/2010 12:39 PM (GMT -7)   
Here is a pdf file that explains a bit more about the differences between the two:
 
 @--->--SHERRY--<---@
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(6 daily),6mp(50-100mgs),Bentyl, Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate ALL mesalamines**~Allergies-Singulair, Zyrtec~Secondary Reynauds Syndrome~Sacroiliitis~bulging and herniated discs C5/C6 & C6/C7~Epidural injections (2 series of 3), OA-Tylonel Arthritis, Celebrex, Fibromyalgia (diagnosis pending)
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KrissyUC
Veteran Member


Date Joined Feb 2010
Total Posts : 971
   Posted 2/24/2010 12:59 PM (GMT -7)   
whooooooooa info overload for me..no simple explanations i guess ? :)
I will talk to my pharmacist!
UC since Aug 2006
Been a constant battle since Feb 08 after the birth of my son
HUMIRA JUL2008- JAN 2010
Salofalk 9 pills a day
Salofalk Suppositories 1g each night at the moment
Fish oil, VSL, Vit D, Vit C, Vit B12 3x weekly Flax oil, reduced red meat, refined grains and dairy
physillium husks -1 cap with each meal
 
Current Status: 1-3 BM a day, would not consider this remission cuz of the urgency...


quincy
Elite Member


Date Joined May 2003
Total Posts : 25893
   Posted 2/24/2010 2:40 PM (GMT -7)   
It's not available in Canada.

Red_34
Forum Moderator


Date Joined Apr 2004
Total Posts : 22185
   Posted 2/24/2010 2:40 PM (GMT -7)   
Lol sorry...some people here like the technical version and some like it simple. Me - I prefer the simple version too! Mesalamine and Basalazide are both 5-ASA's however they are broken down differently in the colon. Most of it has to do with the PH level in the colon as to where the med is broken down. Mesalamines such as Asacol are designed to release its med at the beginning of the colon and spread downward while Basalazide is intended to release its med on the left side of the colon. Neither one works better then the other. It all depends on how the body is going to process it.
 @--->--SHERRY--<---@
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(6 daily),6mp(50-100mgs),Bentyl, Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate ALL mesalamines**~Allergies-Singulair, Zyrtec~Secondary Reynauds Syndrome~Sacroiliitis~bulging and herniated discs C5/C6 & C6/C7~Epidural injections (2 series of 3), OA-Tylonel Arthritis, Celebrex, Fibromyalgia (diagnosis pending)
To help Healingwell - click here: DONATE
 
 
 
 
 

 
 


KrissyUC
Veteran Member


Date Joined Feb 2010
Total Posts : 971
   Posted 2/24/2010 2:42 PM (GMT -7)   
I would think the one that releases on the left is better for pple with left sided illness?
UC since Aug 2006
Been a constant battle since Feb 08 after the birth of my son
HUMIRA JUL2008- JAN 2010
Salofalk 9 pills a day
Salofalk Suppositories 1g each night at the moment
Fish oil, VSL, Vit D, Vit C, Vit B12 3x weekly Flax oil, reduced red meat, refined grains and dairy
physillium husks -1 cap with each meal
 
Current Status: 1-3 BM a day, would not consider this remission cuz of the urgency...


Red_34
Forum Moderator


Date Joined Apr 2004
Total Posts : 22185
   Posted 2/24/2010 2:57 PM (GMT -7)   
Yep :)
 @--->--SHERRY--<---@
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(6 daily),6mp(50-100mgs),Bentyl, Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate ALL mesalamines**~Allergies-Singulair, Zyrtec~Secondary Reynauds Syndrome~Sacroiliitis~bulging and herniated discs C5/C6 & C6/C7~Epidural injections (2 series of 3), OA-Tylonel Arthritis, Celebrex, Fibromyalgia (diagnosis pending)
To help Healingwell - click here: DONATE
 
 
 
 
 

 
 


Old Hat
Veteran Member


Date Joined Feb 2007
Total Posts : 4615
   Posted 2/25/2010 6:09 PM (GMT -7)   
The brandname (U.S.) is Colazal-- the generic name is balsalazide disodium. It is designed to break down to mesalamine through bacterial action within the colon, whereas Asacol & Pentasa start dissolving in the terminal ileum. Then you have the extended release mesalamines, Lialda & Apriso, that require fewer pills daily. Just be aware that some of us have gotten sick on the generic Colazal! The brandname is very expensive, but a wonderful help if it works for you. / Old Hat (30 yrs with left-sided UC; presently in remission taking brandname Colazal)
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