were you taking ibuprofen when your UC began?
6
No - 33.3%
9
yes - 50.0%
0
Not sure - 0.0%
2
Yes, without food - 11.1%
1
Yes, with food - 5.6%

 
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mshowe
New Member


Date Joined May 2010
Total Posts : 1
   Posted 5/28/2010 11:34 AM (GMT -6)   
I have a question for you fellow UC sufferers. Recently had my colonoscopy. I have had some change in my condition (dysplasia) yet I am feeling about the same.

I was diagnosed with UC in about 1990. I am 43 now. At the time I was diagnosed, I was in a stressful job and was taking ibuprofen regularly for neck and shoulder muscle discomfort. Stupid me, i was not taking it with food "as directed".

Every medical person I ask says that could not have brought it on, but prior to that period in my life, I was completely "normal" in regards to my "poop".

so here's my questions, any of you out there have any question about the use of ibuprofen and causing/bringing on your UC?

Also, do you hear of any research happening in an attempt to find some type of a cure?

suebear
Forum Moderator


Date Joined Feb 2006
Total Posts : 5409
   Posted 5/28/2010 11:39 AM (GMT -6)   
You have to have a genetic predisposition for UC in order to "get" UC. There are "triggers" for the first flare. Triggers can be use of antibiotics, stress, food borne illness, etc. Maybe your use of ibuprofen was a trigger but you would have eventually had a flare without the use of it.

Sue
dx proctitis in 1987
dx UC in 1991, was stable until 1998

1998 started prednisone, asacol, pentasa, nortriptylene, ativan, 6MP, rowasa enemas and suppositories, hydrocortisone enemas, tried the SCD diet, being a vegetarian, omega 3s, flax, pranic healing, yoga, acupuncture, probiotics

2000 lost all my B-12 stores and became anemic

2001 opted for j-pouch surgery- now living life med-free


subdued
Veteran Member


Date Joined Dec 2008
Total Posts : 3231
   Posted 5/28/2010 6:20 PM (GMT -6)   
You don't have to have a genetic predisposition. Some people have UC, because they took Accutane. Others, like me, have it because they abused antibiotics. And even others have it because they are predisposed. There are many reasons one can get UC. That's why the cause is unknown. I do believe you can get colitis from abusing ibuprofen even if you aren't genetically predisposed.

Here are some definitions of UC:

A relatively common disease that causes inflammation of the large intestine (the colon). The cause is unknown.

A disease that causes ulcers and inflammation in the inner lining of the colon and rectum.

An inflammatory bowel disease that affects the large intestine, or colon, and is characterized by ulcerations in some portion (right, left, segments or entirety) usually leading to bloody diarrhea and often with complications in other parts of the body.
Colitis is in remission. No longer get IBS.
 
Figuring out how to reduce a flare or get into remission is a trial and error experience. Don't expect your GI to have all the answers. He was trained in making diagnoses, prescribing medications, and surgically removing the colon. He was not trained in alternative treatments. That's why they are called alternative treatments.

What works for me: Fecal transplantation, Probiotics, Anti-inflammatory foods, No HFCS, No crystalline fructose, No foods high in fructose, No artificial sweeteners, No pro-inflammatory foods when flaring, vitamins & supplements, Lexapro (for stress).

Post Edited (subdued) : 5/28/2010 5:25:49 PM (GMT-6)


Ugh Just Ugh
Veteran Member


Date Joined Jan 2010
Total Posts : 1004
   Posted 5/29/2010 7:56 AM (GMT -6)   
For me, I think the trigger that started my UC was hormonal. I started having problems after my pregnancy and was diagnosed 6 months after.

The only research that I've heard of that may end up being a cure is my GP telling me about one of his patients that was in a stem cell study. Apparently she was very far gone and now she's doing very well.
Jennifer
Originally Diagnosed: 7/08 Mild left sided UC
Current Flare started 12/26/09: Severe Inflammation through Entire Colon, some patchiness indicates might be Crohn's.
Current Meds: Prednisone 20mg (Trying to taper again!), Imuran 150mg, Lexapro (5mg), Xanax (.25mg) as needed.
Past Meds: Mesalamine Enemas, Canasa Suppositories, Hydrocortisone Enema & Supp.
Supplements: Multivitamin, Fish Oil, C, Iron, D, Calcium, Potassium, Bio-K, Primadophilus Reuteri, Ultimate Flora Critical Care.


subdued
Veteran Member


Date Joined Dec 2008
Total Posts : 3231
   Posted 5/29/2010 5:26 PM (GMT -6)   
This is how I feel about the whole predisposition and trigger debate:

You get pregnant and your colon starts inflaming. It good be the case that you are predisposed to getting colon inflammations and that getting pregnant (or a hormonal change) was your trigger.

You take medication that kills the bacteria in your colon and now your colon keeps getting inflamed. Are you predisposed to getting colon inflammations? Was taking medications your trigger? After all, you are human; so you do have genes that can produce inflammation in the body when something is wrong. Somehow, I don't buy into this theory.
Colitis is in remission. No longer get IBS.
 
Figuring out how to reduce a flare or get into remission is a trial and error experience. Don't expect your GI to have all the answers. He was trained in making diagnoses, prescribing medications, and surgically removing the colon. He was not trained in alternative treatments. That's why they are called alternative treatments.

What works for me: Fecal transplantation, Probiotics, Anti-inflammatory foods, No HFCS, No crystalline fructose, No foods high in fructose, No artificial sweeteners, No pro-inflammatory foods when flaring, vitamins & supplements, Lexapro (for stress).


BrittNC
Regular Member


Date Joined Jul 2010
Total Posts : 20
   Posted 7/13/2010 11:50 PM (GMT -6)   
Holy crap.
My exact thoughts!!!
 
That was the FIRST thing I asked my doctor when diagnosed because I was taking Ibuprofen DAILY for my migraines.
 
 
I just seriously think they are related... in some way. 
19 years old
 
Diagnosed with UC in 2007(Pancolitis) and still having flareups.
Taking Asacol 4 pills 3x a day.
Ibuprofen for migraines (Only thing that will help them)
Calcium and potassium supplements
 


Red_34
Forum Moderator


Date Joined Apr 2004
Total Posts : 22023
   Posted 7/14/2010 6:29 AM (GMT -6)   
There are so many unknown variables about this disease that it's hard to say what causes it and what doesn't. All we can do is speculate at this time.

For me however, I do believe I have a genetic disposition to it considering my mother had Crohn's and my great grand mother had some sort of IBD (it was too long ago and I don't think they had a name for it yet). When I first got diagnosed, I was constantly sick and was on antibiotics a lot. Along with the antibiotics I was taking Advil because most of the time, my illnesses involved pain (strep, ear infections etc). I was also under a lot of stress at work and then not to mention, I got pregnant. So a year after I had my son, all heck broke loose. UC here I come! :(
 @--->--SHERRY--<---@
Moderator-Allergies/Asthma, Co-moderator-UC and Alzheimer's
~Left sided Uc-'92**Unable to tolerate ALL mesalamines**
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hateuc
Veteran Member


Date Joined Jun 2010
Total Posts : 1785
   Posted 7/14/2010 8:04 AM (GMT -6)   
I was under alot of stress and was having major headaches so I was taking alot of advil. I can't help but to think that was the trigger along w/ a predisposition of course. If only I could turn back time....... but who knows I may have gotten it anyway.
B
Proctosigmoiditis
2 Lialda/day  Rowasa nightly
VSL#3
Metamucil wafers


deltaforce
Veteran Member


Date Joined Jun 2010
Total Posts : 1866
   Posted 7/14/2010 9:23 AM (GMT -6)   
Its possible it is related. What I see here is the stress that you were through. In old literature, UC is called as Stress disease and still it is. Its just we don't understand how body handles stress i.e. what are chemical ramifications of stress, that trigger UC. Ibuprofen contributed to the inflammation as side effect.

In my case, I started getting migraines after a year of UC diagnosis. Until yesterday, I was taking naproxen for my migraine. I had a very clear pattern, when I taken naproxen, I get blood in the poop exactly after 30 hours of naproxen intake. Now, I am on Meaprolol for migraine. Lets see if migraines continue.
Long story short, Ibuprofen didn't cause UC, it exacerbated the symptoms.

Male, Otherwise healthy, Non-Smoker and a teetotaler.
Flared for about a year before colonoscopy and official diagnosis of IBD on 23rd March 2007, at the age of 30 years.
Currently taking -
Colazid 2250mg 3X a day,
Azathioprine 150mg a day,
Salazopyrine Suppository 500mg, one every night (Stopped since 2nd June 2010)
Mesalamine 1gm enema 2X a day (since 2nd June 2010)
Metaprolol 20mg, once a day for migraine (since 13th July 2010)

Otherwise serious migraine headache. Possible culprit for migraine is Azathioprine. Migraine is affecting quality of life way more than IBD.

I just give suggestions. You decide what to do with it.


KrissyUC
Veteran Member


Date Joined Feb 2010
Total Posts : 971
   Posted 7/14/2010 9:43 AM (GMT -6)   
I believe mine is genetic as 4 others in my family have UC as well. When I was diagnosed I was not taking Advil but after I gave birth to my son I was taking it...alot of it..like 2 every four hours for days and days..I flared REALLY REALLY REALLY bad after that..
I dont take it any more..at all..always opt for Tylenol instead and try to avoid antibiotics all the time as well..I am doing ok now.
28 yr old female
Pancolitis since Aug 2006
HUMIRA JUL2008- JAN 2010
Salofalk 12 pills a day (upped from 9 on May 15/2010)
Salofalk 12 pills a day
Salofalk 4g Enemas every 2nd night, started March 9/2010, Salofalk suppositories every 3rd morning , started May 5 2010
Fish oil, VSL1 packets per day, Vit D, Vit C, Vit B12 3x weekly , Ultimate Floral Critical Care X 2 caps a day
Current Status: coming out of a mild flare...


BrittNC
Regular Member


Date Joined Jul 2010
Total Posts : 20
   Posted 7/14/2010 11:36 AM (GMT -6)   
I just seem to think that my stomach disease was caused from Ibuprofen.
I had NO problems from my stomach until I had been taking Ibuprofen all the time for migraines.
Just assuming but it is quite alarming.
19 years old
 
Diagnosed with UC in 2007(Pancolitis) and still having flareups.
Taking Asacol 4 pills 3x a day.
Ibuprofen for migraines (Only thing that will help them)
Calcium and potassium supplements
 

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