BUTYRATE ENEMAS -ANYONE?

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UniG
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Date Joined May 2009
Total Posts : 110
   Posted 8/8/2010 8:02 AM (GMT -6)   
My naturopath gave me a Butyrate Enema from AOR (a Canadian health company) to try.

I have to buy some more Salofalk enemas right away but wouldn't mind trying these instead for awhile. Has anyone had any experience? There's not much on this site about them.

thanks friends,
Uni-g

cupcakespinkgal
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Date Joined Jun 2010
Total Posts : 720
   Posted 8/8/2010 8:30 AM (GMT -6)   
I have not used them as an enema but have started taking it as a supplement. I have read about it as an alternative treatment and contemplated dissolving some of my capsules to make an enema.

I think the supplement is helping, the bleeding has not subsided but my pain has greatly decreased and my guts feel a little calmer than before.
Diagnosed with Crohn's in 1998, father has UC we were diagnosed at the same age.

Currently on 20 mg Prednisone, 2g Sulfasalzine, Butyric Acid, Kefir/probiotics, Curcumin, Magnesium, D3, B complex vitamin, and multi-mineral. Previously on Remicade, stopped Humira after 9 months, wasn't working.

No surgeries so far.

quincy
Elite Member


Date Joined May 2003
Total Posts : 25775
   Posted 8/8/2010 2:29 PM (GMT -6)   
At least there are some studies on it...


http://www.ncbi.nlm.nih.gov/pubmed/19108937?dopt=Abstract



q

stereofidelic89
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Date Joined Sep 2011
Total Posts : 1923
   Posted 8/8/2012 3:08 PM (GMT -6)   
I was actually going to post the same question. They are essentially fatty acids or components of them, that help aid in the digestion process, and for the purpose of administering as an enema, would help reduce inflammation almost naturally, I believe.

My naturopath just suggested these as well, and I just saw a MD at Vermont Gastroenterology who has never heard of them but gave me samples of Canasa suppositories. I hope my naturopath can supply these to me somehow, this study proves them effective in treating 'pathogenesis of distal ulcerative colitis': www.ncbi.nlm.nih.gov/pubmed/1612357

sean88
Regular Member


Date Joined Jul 2012
Total Posts : 210
   Posted 8/8/2012 6:21 PM (GMT -6)   
My understanding of butyrate enemas is that the butyrate feeds the mucosal/epithelial(?) cells of the lower intestine/colon. This in turn would aid in the healing of the lining. Normally butyrate is produced by bacteria in your gut but this may be deficient in UC. In my case I did CDSA and was found with really low butyrate levels so try to introduce prebiotics to give the probiotics food to produce butyrate. Also considered butyrate enemas to help this but busy with rowasa right now :). I don't believe that oral butyrate would help with this.
Left side UC diagnosed 2009
SCD since March 2011
Meds - Asacol 2.4g
Supplements - E 1000 IU, D 4000 IU, Fish Oil O3 3g, Multivitamin
Probiotics - Kefir, SCD Yogurt, Kirkmans Duo, Bio-K

SS0000
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Date Joined Feb 2012
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   Posted 8/8/2012 7:15 PM (GMT -6)   
Just was talking with my ND about these !

InSoFla
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Date Joined Jan 2011
Total Posts : 4679
   Posted 8/8/2012 7:27 PM (GMT -6)   
Sean is correction how they work.
I've read some pretty good studies on their effectiveness.
Rx meds didn't help me. But 4.5 mg LDN +Paleo diet +supplements=REMISSION.Protein shakes w/almond milk,Maca powder,L-Glutamine,D-Ribose,chia seeds.VSL#3,K2,VIt. D3,slippery elm bark powder.For more info,my protocol is the 11th post at this link: http://www.healingwell.com/community/default.aspx?f=38&m=1666318
If you have any questions, you can find my email address at my profile.

IamCurious
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Date Joined Jan 2010
Total Posts : 2289
   Posted 8/9/2012 7:58 AM (GMT -6)   
Sean88 said...
In my case I did CDSA and was found with really low butyrate levels so try to introduce prebiotics to give the probiotics food to produce butyrate.


Many of us have been helped by regularly taking powdered psyllium seed which increases butyrate levels in the colon:

findarticles.com/p/articles/mi_m0FDN/is_2_7/ai_85522988/
"Anaerobic fermentation of the soluble non-starch polysaccharides from psyllium seed results in the production of the short-chain fatty acids acetate, propionate, and butyrate in the intestines. (4) Psyllium husk contains only the epidermis of the seed, while the actual seed has a higher amount of fermentable fiber. Because of this fiber content, psyllium seed degrades more slowly than pectin and produces fairly large amounts of butyrate and acetate. Butyric acid exhibits antineoplastic activity against colorectal cancer, is the preferred oxidative substrate for colonocytes, and may be helpful in the treatment of ulcerative colitis. In a study of resected colorectal cancer patients, those given 20 grams of psyllium seed daily for three months exhibited an average increase of butyric acid production of 42 percent, which decreased to pretreatment levels within two months of cessation of supplementation. "
Male/60 DX ulcerative colitis Feb08, or maybe Crohn's colitis.
No Meds, allergic to Mesalamine. Remission since Mar10. Food journal instead of SCD or Paleo. Psyllium seed mixed with VSL3 is very helpful.

Lots of fruit & vegetables (but no plums or cruciferous), no soda, no gluten, no HFCS, no xylitol or sorbitol, no trans fat, no shellfish, few processed foods, no carrageenan.
Probiotics, fish oil, multivitamin, extra D3, K2, E complex, phos choline, magnesium, boswellia, curcumin, glutamine.
Nature created all of the locks, therefore Nature has all of the keys

mindoverbutter
Regular Member


Date Joined May 2011
Total Posts : 232
   Posted 8/11/2012 9:42 PM (GMT -6)   
i have heard good things from studies, but usually people who have done them, it just doesn't work out... YMMV
22/m dx May 2009 chronic ulcerative colitis (whole colon)
dx April 2011 leftsided colitis (rest of colon appears normal)
2 Lialda 2x daily
1/11 SCD w/ homemade RAW Goat Milk Yogurt & Freeda Multivitamin
bananas, avacado, spinach, all proteins, carrots, heaps of ginger & garlic, almond flour breads, raw honey
1/13 Pred @ 30mg. 4/8 Off the pred!!! Yay!
SCDophilus 10 bil CFU
JR's Brasco Broth

Petah
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Date Joined Nov 2012
Total Posts : 995
   Posted 1/10/2013 9:51 PM (GMT -6)   
Thought I'd refresh for someone who asked me about butyrate

Lodi
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Date Joined May 2012
Total Posts : 680
   Posted 1/10/2013 10:41 PM (GMT -6)   
I did, thanks.

Would these be a prescription from your GI then?
diagnosed (colonoscopy/biopsy) Feb 2012; U/C throughout entire colon but only partly inflamed?
Big flare right now, on oral prednisone, imuran, mesasal, flagyl, stopped cipro due to side effects
I avoid gluten and dairy, I eat pasture raised meat ; some produce; avoid processed food as much as possible; I use olive oil, coconut oil

Petah
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Date Joined Nov 2012
Total Posts : 995
   Posted 1/10/2013 11:01 PM (GMT -6)   
Yes I'm assuming because I've ask my clueless GP

PalaceDan
Regular Member


Date Joined Aug 2008
Total Posts : 42
   Posted 1/11/2013 6:18 AM (GMT -6)   
I was prescribed these as a suppository a few weeks ago. I had a flex sig two days ago and was told I'm healing. I don't feel so much improved, but the pictures on the flex sig were clearly vastly improved from my colonoscopy a few months back. The issue was that the healing was only in the lower area where the suppository reached, so the dr told me to use two at once to try to get the butyrate higher up. We'll see how that goes.

Thing to add though - this is not a naturopath. This doctor is the head of the IBD department at a major NY teaching hospital. So it would seem to validate it as an option from another perspective/ approach to UC.

I have to have the butyrate suppositories specially prepared at a compounding pharmacy or whatever you call it. Still covered by insurance though.

Petah
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Date Joined Nov 2012
Total Posts : 995
   Posted 1/11/2013 6:36 AM (GMT -6)   
That's great, and even better news for me, I have proctitis. :) thanks for sharing

Pluot
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Date Joined May 2012
Total Posts : 2276
   Posted 1/11/2013 7:17 AM (GMT -6)   
Same story here as PalaceDan (I think we may have the same GI ;)). I have pancolitis so the butyrate suppositories couldn't really put a dent in my symptoms but I had really bad rectal pain/tenesmus at the time and the suppositories were very soothing for me. If you can get them I definitely recommend trying it.
liz, 26
http://itslikethisuc.blogspot.com

dx'ed UC pancolitis 5/12 w/ moderate-severe inflammation

past meds: asacol hd, VSL#3, apriso, rowasa, xifaxan, 6mp, cortifoam, pentasa, cimzia, canasa, butyrate

current meds: flagyl, cipro, prednisone, remicade, methotrexate, cholestyramine, cortenema

supplements: folic acid, vitamin d, potassium

Petah
Veteran Member


Date Joined Nov 2012
Total Posts : 995
   Posted 1/11/2013 5:31 PM (GMT -6)   
Thanks I will give them a go, I want to alternate with the pentasa.

stereofidelic89
Veteran Member


Date Joined Sep 2011
Total Posts : 1923
   Posted 1/11/2013 5:42 PM (GMT -6)   
Hi,

I tried them in the summer for a few days. Had to get them done through a special compound pharmacy. They were $120 bucks for 15 of them I think. Right away I noticed I wasn't able to hold them in, and they caused urgency for me.

When I called the pharmacist he told me that it can't be the glutathione (that i paired with the butyrate), but instead that it was the butyrate, because it was a source of fiber (probably insoluble) that I just couldn't tolerate. :(

The suppositories I'm using now by Wise Woman Herbals are amazing. I've tried Canasa, the butyrate, and another type of suppository in the past, this is the only one that stops bleeding, hemorrhoids, and regulates BM's for me. :)
Diagnosed Crohns-Colitis Sept 2011
Gluten Free-Limit Grains+Sugar, VSL#3, InflaGuard, Zyflamend, Asacol, Wise Woman Supps#2
Metametrix Labs stool testing reveal yeast overgrowth/parasite
Two Month Protocol: Candida Control Diet, Phytostan, ParaGuard, ADP

PalaceDan
Regular Member


Date Joined Aug 2008
Total Posts : 42
   Posted 1/12/2013 3:50 PM (GMT -6)   
Pluot said...
Same story here as PalaceDan (I think we may have the same GI ;)). I have pancolitis so the butyrate suppositories couldn't really put a dent in my symptoms but I had really bad rectal pain/tenesmus at the time and the suppositories were very soothing for me. If you can get them I definitely recommend trying it.
If it's the same one, then you'll know why I hesitate to say who it is - it's impossible enough to get an appointment as it is!

PalaceDan
Regular Member


Date Joined Aug 2008
Total Posts : 42
   Posted 1/12/2013 4:03 PM (GMT -6)   
Petah said...
That's great, and even better news for me, I have proctitis. :) thanks for sharing
I thought I should add something. As someone with 10-15cm proctitis, I'd always been confused by how that small an area of inflammation was causing so much trouble. I can see why it would cause urgency - if that area is essentially slick with mucous and blood then it's not going to do it's job retaining stool I guess. Makes sense.

What I didn't get was why it would cause frequency, and so I'd been ascribing frequency to something else (food intolerances, IBS or some combination). But that was wrong.

When I had the flex sig last week it was clear that something, with the butyrate suppositories being the most likely suspect, was making healing happen - for the first time for a while with the exception of a few weeks into prednisone - I could see the pictures and where my colonoscopy a few months ago looked uniformly red and raw in that area, now it looked normal with the exception of one obvious individual ulcer and a much smaller inflamed area. So you didn't have to be an expert to see it was much better.

But - my symptoms (urgency and frequency) are still there - improved, but definitely not gone away. And that's why I had been about to stop the butyrate until the flex sig was done.

So I asked why would such minimal inflammation cause such pronounced symptoms. I guess you may all know why already, but it was news to me. Even minimal inflammation and inflammation in the rectum is interpreted by the bowel as something which needs to be expelled. So that small ulcerated area it provokes my bowel to try to empty out in order to get rid of what's there - even though what's there is in fact just the inflamed tissue.

Bottom line (pardon the pun) is that, for me at least, I'll still have symptoms until the inflammation is gone, and that may take a little while - I have been in a continuous low-level flare to varying degrees since 2007, so I shouldn't expect things to happen overnight. But I can't take continuing symptoms to mean that healing isn't happening when it visibly is.

Just thought I'd share that, as it's important for me - it means that I can't necessarily tell if something is working or not purely on the basis of the severity of my symptoms. I know I've tried a lot of things and then given up when symptoms didn't improve. I was going to do the same with the butyrate enemas as the symptoms weren't going away. But that would have been a mistake.

Incidentally, I realise it's possible that the use of the butyrate suppositories may just be coinciding with me going into remission anyway. The thing is, I haven't been in remission since 2007. Maybe the butyrate won't get me all the way. But it would be odd to have the best exam since diagnosis coincide with starting them. Could be though of course.

deltaforce
Veteran Member


Date Joined Jun 2010
Total Posts : 1951
   Posted 1/12/2013 8:58 PM (GMT -6)   
stereofidelic89 said...

The suppositories I'm using now by Wise Woman Herbals are amazing.

Are these butyrate suppositories? Sorry, I lost you there.
I was just checking a compounding pharmacy today and they have mesalamine+butyrate rectal preparations. Did you get something similar (that you could not hold)?
Diagnosed March 2007 with left sided UC at the age of 30.
Currently on,
Colazal 9 daily, Imuran, 200mg daily, Vit. B12, 1mg, Multivitamin, 1 tablet daily, Fish oil 2400mg daily, Vit D 2000 IU daily.

Verapamil 320mg for migraine, Migraine episode now at least 4X a month,
Nabumetone 750mg as an abortive, so far so good with GI side effects.

TMP123
New Member


Date Joined Jul 2011
Total Posts : 3
   Posted 1/13/2013 12:23 AM (GMT -6)   
I've been using butyrate suppositories since the summer. ( I wonder if we all have the same doc in NYC)
I was diagnosed with proctitis 3 years ago, apriso, canasa, rowasa, and a cortenema do very little. Was put on remicade and did wonderfully but after 6 months I started to have bad side effects that included elevated liver enzymes along with remicade induced psoriasis.
The butyrate seems to work, I've haven't had any increase of inflammation in the rectum, but my last colonoscopy in December did show the onset of inflammation throughout the entire colon.
With 2013 insurance changes to my prescription coverage I now am forced to take colozal rather than the Apriso. I'm in the process of getting Cimzia approval.
My doc is hoping the Cimzia will kick me into remission and let the butyrate do what it's suppose to do. Fingers crossed.

Petah
Veteran Member


Date Joined Nov 2012
Total Posts : 995
   Posted 1/13/2013 2:02 AM (GMT -6)   
How is it TMP123 that you have no inflammation in the rectum, but in the Colon? Would it still be considered proctitis?

taroki
Regular Member


Date Joined Oct 2013
Total Posts : 59
   Posted 5/22/2014 5:46 PM (GMT -6)   
bump ...

Would butyrate or butyrate enemas help with bad gut flora, leaky gut with sulphite/histamine sensitivities, and h.pylori?
+/+ VDR Taq, ACAT1-02, BHMT-08
+/- MTHFR A1298C, COMT P199P, MAO-A R297R, MTRR A66G, BHMT-02, BHMT-04, AHCY-01, AHCY-02, AHCY-19, CBS A360A

I have Lyme w/coinfections, Mercury, KPU/HPU, Pesticides, Electrosensitivity, Intestinal Candida/Yeast, Sulphur/Sulphite Sensitivity, Histamine Intolerance

Katika
New Member


Date Joined Apr 2014
Total Posts : 8
   Posted 5/26/2014 9:11 AM (GMT -6)   
Taroki, I think you should try a gut healing protocol such as the GAPS Diet or an autoimmune paleo protocol and for Candida maybe the Body Ecology diet. Butyrate is very beneficial, but not a be all and end all.

upstategal
Regular Member


Date Joined Dec 2011
Total Posts : 77
   Posted 5/26/2014 10:21 AM (GMT -6)   
TO: stereodefelico89, can you please tell me the name of the suppositories you are ordering from Wise Woman Herbals?? I would sure like to try them.
Dx 11/28/11 at 58 with left sided Ulcerative Colitis with Proctitis
Current meds: Lialda 2 tabs bid, 1 Canasa 1000mg suppository twice daily or Hydrocortisone enemas nightly prn,
4/14 Prednisone 40 mg- doing taper- flare started 4/14, hospitalized 5/12-5/16/14
Asthma/allergy meds: generic Zyrtec, Singulair, Qvar and inhaler PRN
Supplements: B vitamin once a day with folic acid, iron with vit.
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