Diagnosed with Clostridium Difficile

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MaxMilian
Veteran Member


Date Joined Dec 2010
Total Posts : 1171
   Posted 1/19/2011 3:24 AM (GMT -6)   
Hey Guys, I haven't posted in a while. My UC history is basically summed up in my signature but I noticed my signature is not coming up when I post so I will give a brief summary.
 
 Basically in 1st Oct 2010 I was diagnosed with proctitis (6cm of inflammation). Symptoms that I felt before were a little bit of blood on the toilet paper, that's it (no urgency, stool was normal, 2 bowel movements a day). After diagnosis I used one Pentasa suppository a night which cleared the bleeding up in 3 days. The problem was the colonoscopy's biopsies came back as me having a normal bowel so I went for a 2nd colonoscopy on the 30th of November. Results came back as mild inflammation in the rectum (5cm) and slight inflammation in the cecum (biopsies confirmed my doctor's observation). I continued to use the Pentasa suppositories but added in two sachets of Salofalk granules a day. However, me being paranoid, I went for a 3rd colonoscopy which came back with my UC almost 100% healed aside from very faint inflammation in the rectum and a tiny bit of inflammation in the cecum.
 
 Anyway, after my 3rd colonoscopy I pushed my GI for a stool test even though he believed that it would come out normal.
 
 My GI called me with the results today and it turns out I have a case of C.Diff. Toxins A and B of the C.Diff were not present in my stool but the C.Diff was cultured in the stool. My GI says it could be a minority strain of C.Diff that doesn't produce toxins. I am feeling really anxious at the moment because in about 3 weeks I am about to fly for studies in China for one year and I thought I had my UC figured out... now I am hit with this news and I am not sure what to expect.
 
 I have an appoinment with my GI tomorrow in the afternoon and on the phone he said he was going to prescribe me a course of Flagyl. I have read that this is the primary antibiotic used to treat C.Diff.
 
 Currently my bowel movements are about 3 times a day, mostly all mushy. I have slight urges during the day but usually they disappear quickly. I still have slight lower left/right abdominal aches (but nothing severe). These are the symptoms I still feel despite my 3rd colonoscopy (and biopsies) stating that my proctitis is almost completely gone (in fact the biopsies couldn't detect any inflammation after the 3rd colonoscopy).
 
 Since my diagnosis with UC my family have firmly believed that my UC was caused by antibiotics (Bactrium DS) which I took for about 2 years for acne. This would be in line with my C.Diff diagnosis.
 
 My questions are:
 
1) What can I expect after treatment of the C.Diff?
 
2) What is the recommended treatment of C.Diff? I read that in addition to taking the Flagyl, I should supplement it with a high dose of probiotics. At the moment I am taking VSL #3 (one sachet per day) but I assume when I start Flagyl, I will have to increase this dose.
 
3) Should I be worried that I have C.Diff?
 
4) What are the side effects of Flagyl? Are there any other antibiotics that I can read about that I could possibly be prescribed?
 
 Sorry to sound like I am panicking but I am already starting to pack my bags and now I have this to contend with... I am really nervous.
 
 Thanks for the support.
 
 Max

Post Edited (MaxMilian) : 1/19/2011 2:33:36 AM (GMT-7)


blksteeda
Veteran Member


Date Joined Dec 2009
Total Posts : 859
   Posted 1/19/2011 5:18 AM (GMT -6)   
I've had C Diff quite a few times and was always given Flagyl for treatment. Mine always developed from taking antibiotics and sometimes showed up weeks after antibiotic treatment. You may also get Vancomycin as well. It's always good to up the probiotics when taking any antibiotic but you may not need it if you're taking VSL3 as it's such a large bacteria count but it couldn't hurt if you took a little more during the course of the treatment. I never had any side effects with the Flagyl and tolerated it very well.
Gordon / Male / 37


Active Ulcerative Colitis (left sided)

50mg / 6mp

Colazal 3-3x/day

Rowasa Enemas every other night

Prednisone again - 5mg

Remicade Infusion 10mg/kg started 04/10/10

______________________________________



______________________________________

imagardener2
Veteran Member


Date Joined Jan 2010
Total Posts : 3492
   Posted 1/19/2011 6:31 AM (GMT -6)   
"Florastor" is an OTC supplement that can be taken to help your gut fight bad bacteria while also taking antibiotics. Check with your doctor but it's been around a very long time with many studies showing beneficial results.

You are lucky (in a sense) your tests showed C. difficile. From what I read it is extremely difficult to detect in stool tests, therefore untreated many times.

www.medicalnewstoday.com/articles/105956.php
from the link:
"... traditional treatment for C. diff-associated disease is the use of powerful antibiotics such as metronidazole or vancomycin, but one of the most troublesome aspects of the disease is it's high rate of recurrence. But studies show that adding the yeast-based probiotic Saccharomyces boulardii (sold under the brand name FlorastorĀ®), can cut the rate of recurrence by about half. "
In remission April 2010 after 10 years of UC with no remission ever
Jan 2010 began SpecCarbDiet (modified to remove dairy, fruit & juices,)
Gluten-free=bleeding stopped in 3 days, 95% remission in 5.5 months on SCD
SCDiet: Gluten/grain-free, starch-free, low carb, honey as sweetener
(9)Balsalazide+(6)Citrucel+VSL#3 daily, mesalamine enema as needed
Curcumin/turmeric pill, D3 5000, L-glutamine

Post Edited (imagardener2) : 1/19/2011 6:05:51 AM (GMT-7)


MaxMilian
Veteran Member


Date Joined Dec 2010
Total Posts : 1171
   Posted 1/19/2011 6:56 AM (GMT -6)   
What happens if C.Diff is left untreated?
History:
[1st Oct 2010] 1st colonoscopy. Diagnosed with 6cm moderate proctitis
[30th Nov 2010] 2nd colonoscopy. 5cm proctitis with additional inflammation in cecum.
[10th Jan 2011] 3rd colonoscopy. Nearly healed 5 cm proctitis and additional moderate cecum inflammation.

Current Meds:
- 1g Pentasa suppositories (1 daily)
- 1.5g Salofalk granules (2 daily)

blksteeda
Veteran Member


Date Joined Dec 2009
Total Posts : 859
   Posted 1/19/2011 9:13 AM (GMT -6)   
this wikipedia link has a lot of good info...it does mention if left untreated it can potentially cause sepsis or bowel preforation

http://en.wikipedia.org/wiki/Clostridium_difficile
Gordon / Male / 37


Active Ulcerative Colitis (left sided)

50mg / 6mp

Colazal 3-3x/day

Rowasa Enemas every other night

Prednisone again - 5mg

Remicade Infusion 10mg/kg started 04/10/10

______________________________________



______________________________________

blksteeda
Veteran Member


Date Joined Dec 2009
Total Posts : 859
   Posted 1/19/2011 9:15 AM (GMT -6)   
take a look at this thread here as well

http://www.healingwell.com/community/default.aspx?f=38&m=1072333
Gordon / Male / 37


Active Ulcerative Colitis (left sided)

50mg / 6mp

Colazal 3-3x/day

Rowasa Enemas every other night

Prednisone again - 5mg

Remicade Infusion 10mg/kg started 04/10/10

______________________________________



______________________________________

Alba29
Regular Member


Date Joined Nov 2010
Total Posts : 253
   Posted 1/19/2011 10:46 AM (GMT -6)   
I'm so paranoid about this - tested the stool several times and the GI also took some samples during the colonoscopy to make sure it's negative. Is it possible to have it and be asymptomatic?

quincy
Elite Member


Date Joined May 2003
Total Posts : 25142
   Posted 1/19/2011 11:18 AM (GMT -6)   
c.diff is in our colons anyway. But, when the imbalance is caused by antibiotics, it apparently multiplies creating a toxic component that can cause infection..sometimes to the point where it cannot be cured and the colon must be removed. (pseudomembranous colitis).

We can also pick up the toxic c.diff on our hands and ingest it. Apparently once the infection is nonsymptomatic, it can still be active in the poo, hence the easy spread.

If c.diff is untreated when its imbalance is creating toxic spores or whatever it is called....you may run the risk of spreading it or never being able for it to be treated.

I don't think you have a choice.....really.

Sort of treating in part but not continuing creates those superbugs we all fear.

Your situation is difficult because you're leaving for China...but you'll just take this with you....

q
*Heather* I give suggestions, do with them what you will.
Status: ...Asacol 3 @ 2x daily; Salofalk enema @ 3rd night (nightly/ flares, tapered/maintenance)
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol 20mg as needed; Zantac 150mg; Symbicort/Airomir (asthma)
~vitamins/minerals/supplements; Probiotics....(RenewLife Ultimate Flora Critical Care+Primadophilus Reuteri capsules @ bedtime)
~Metamucil capsules 6 twice daily with meals; Vitamin D 4000 IU
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS" worth it !!!

MaxMilian
Veteran Member


Date Joined Dec 2010
Total Posts : 1171
   Posted 1/19/2011 2:27 PM (GMT -6)   
Thanks for the replies guys. I am not sure if I am having any symptoms or not. As i said above, my GI said my C.Diff was one that didn't produce toxins (which is why my first stool test didn't detect any C.Diff). Before my UC diagnosis I was having about 2 BMs a day, with not much urgency felt during the day and usually formed stools. I do feel slight urgency now, average about 3 BMs a day and usually have mushy stool (which can't be explained by the state of my UC). Prior to the C.Diff results my GI said it was simply IBS. I am going to see him today and ask if my current symptoms can be explained by my C.Diff infection.

My biggest concern is that I may not be able to treat the infection in time before I leave. Since I leave in about 20 days, antibiotic treatment may take 10 days, then another stool test might take 10 days. What if on the day of my departure the results say I am still infected. I might ask to take a course of Vancomycin with me in the event Flagyl is not enough to stop the infection. And even if the result comes back as C.Diff free, how can i be sure the results are correct since my first stool test could not detect the infection.

Honestly it feels like some unknown force is trying to stop me from leaving country. First UC and now this.

Post Edited (MaxMilian) : 1/19/2011 1:34:15 PM (GMT-7)

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