Does taking Niacin help with UC?

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BabeintheWoods
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   Posted 5/11/2011 7:47 AM (GMT -6)   
LEASE said...
Prostaglandin E2: One of the prostaglandins, a group of hormone-like substances that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation. Prostaglandin E2 (PGE-2) is released by blood vessel walls in response to infection or inflammation that acts on the brain to induce fever. The enzyme mPGES-1 is involved in the production of PGE2 and is an important "switch" for activating the fever response.

This is from LEASE's thread a few days ago. The implication is that niacin may be effective for UC:

www.colitisrecovery.com/ulcerative-colitis-prostaglandin-d2-stops-flare-ups
Researchers at the Farncombe Family Digestive Health Institute have discovered that having elevated levels of Prostaglandin D2 is a key factor in Preventing Ulcerative Colitis flare ups, and triggers long term remission of Ulcerative Colitis...
It appears that Niacin may naturally increase levels of prostaglandin D2 as well as lowering cholesterol and triglycerides.


I am in remission right now but I think niacin might be helping. Niacin is also known as vitamin B3 and if you take B vitamins they need to be balanced. For example taking too much B3 alone can induce a deficiency of vitamin B6. So if taking extra niacin then also include a multiple vitamin or at least a pill with B complex.
Male/59 DX ulcerative colitis Feb08, possible Crohn's colitis DX Mar10.
No Meds, allergic to Mesalamine. Remission since Mar10. Psyllium seed mixed with VSL3 especially helpful. Food journal instead of SCD.

Boswellia, turmeric, fish oil, S. Boulardii, resveratrol, multivitamin, extra D3, K2, C, high gamma E, magnesium, phos choline, glutamine, probiotics. Lots of fruit & vegetables(but no plums or kale), no soda, no HFCS, no trans fat, no shellfish, tea instead of coffee, watch gluten, few processed foods, no carrageenan.
Nature created all of the locks, therefore Nature has all of the keys

Levi
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   Posted 5/11/2011 8:02 AM (GMT -6)   
I read some research along the same lines as what you posted back when people first started posting ths prostaglandin D2 study and started looking into Niacin. I pretty much wrote it off because I information I found showing how hard it can be on the liver.
 
Have you come across anything discussing that about niacin?

aguywithuc
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   Posted 5/11/2011 8:28 AM (GMT -6)   
I am taking 125mg per day, 25 in one pill and 100 in a B-complex. Liver numbers have been fine, will be getting more on Friday.

imagardener2
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   Posted 5/11/2011 9:31 AM (GMT -6)   
I also was interested in LEASE's post and ordered some Niacin online because it was expensive locally and also wanted a smaller mg pill so I could start low (50 mg) and add more pills on when I was sure it wasn't giving negative results (not arrived yet).

Thanks for the info about balancing with B6 since I don't take any vitamins at all currently. I'll be getting a blood test in July but never had liver issues previously. Is there any test I should request?

Have you ever had any side effects from niacin like flushing, heart rate increase, etc?
In remission April 2010 after 10 years of UC with no remission ever
Jan 2010 began SpecCarbDiet (modified to remove dairy, fruit & juices,)
Gluten-free=bleeding stopped in 3 days, 95% remission in 5.5 months on SCD
SCDiet: Gluten/grain-free, starch-free, low carb, honey as sweetener
(9)Balsalazide+(6)Citrucel, mesalamine enema as needed
Spinach & sunflower seeds daily, (1) VSL#3 nightly

BabeintheWoods
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   Posted 5/11/2011 11:47 AM (GMT -6)   
Niacin works better than statins for heart health because it lowers LDL, triglycerides, and lipoprotein(a), while it raises the good HDL. Statins only lower LDL. Big Pharma is taking advantage of this by coming out with the prescription Niaspan. (They also took advantage of the benefits of fish oil by coming out with the prescription Lovaza.)

Over 100 mg of niacin can produce the niacin flush which makes people uncomfortable but is supposedly harmless. I don’t know but maybe that is what we are looking for? Prostaglandin (PGD2) is the primary cause of the flushing reaction, and I think PGD2 is what helps UC? Other forms of vitamin b3 like niacinamide and inositol hexanicotinate do not cause flushing. And they might not benefit heart health either as well as niacin? (not sure).

I have heard that niacin puts a strain the liver. That is why it may be better to not take it in a timed release capsule. Time release is popular because it avoids the niacin flush but it also means that your liver is receiving niacin all day long and does not have a chance to recover. Statins also strain the liver and have other side effects.

Everyone knows that it is hard to overdose on water soluble vitamins such as vitamin C because the body just excretes the excess thru the kidneys and urine. B complex are also water soluble but they are a bit tricky. The body excretes the excess in a package deal. So if you take too much of one B vitamin your body will get rid of it but also rid some of the other B vitamins as well. That is why too much of one may cause of deficiency of some others.

This used to be common knowledge years ago, how too much B1 creates problems for B2, etc., but now even with Google I cannot find more info on this.

imagardener2
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   Posted 5/11/2011 4:53 PM (GMT -6)   
Babe

Thanks for the additional info. Yes I avoided the time release and fancy-dancy niacin, just got the old-fashioned kind.
I guess I can stand the flushing if I made it through menopause. Hot flashes ceased when UC got bad. Connection?
Too bad it's already 90 degrees here in Florida.

When it arrives I'll start with 50 mg for a week (and start a multi-vitamin) and move up slowly given my poor history with supplements.
In remission April 2010 after 10 years of UC with no remission ever
Jan 2010 began SpecCarbDiet (modified to remove dairy, fruit & juices,)
Gluten-free=bleeding stopped in 3 days, 95% remission in 5.5 months on SCD
SCDiet: Gluten/grain-free, starch-free, low carb, honey as sweetener
(9)Balsalazide+(6)Citrucel, mesalamine enema as needed
Spinach & sunflower seeds daily, (1) VSL#3 nightly

aguywithuc
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Date Joined Jun 2010
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   Posted 5/11/2011 5:17 PM (GMT -6)   
BabeintheWoods said...
Niacin works better than statins for heart health because it lowers LDL


OK sounds like you have researched this well. We always see that we should be supplementing with Folic acid (also known as vitamin B9, vitamin Bc or folacin) - but given the package nature are we fine with just one B-complex daily and forget about adding in Folic acid since it is already in there ?

BabeintheWoods
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   Posted 5/11/2011 5:44 PM (GMT -6)   
I really don't know. I don't mind poisoning myself but would feel terrible if someone hurt themselves from something I said.

Folic acid is used to prevent birth defects but I don't know how much is needed. One way to determine if you are deficient might be (just guessing here) to get your blood levels of homocysteine tested. High homocysteine is one of the risk factors for heart disease.

High homocysteine can result from a deficiency of B12, B6, or folic acid (B9). So I guess if it is high you can probably add these to see if it helps lower it to normal. If adding these 3 vitamins does not help enough then you can always try adding SAMe. Very pricey but supposedly good for homocysteine, heart health, arthritis, and depression.

Since everyone may absorb different nutrients differently you may need more of one than somebody else. E.G. some of us over 50 have problems absorbing B12. I think blood levels of B12 and folic acid can be tested with blood work.

Post Edited (BabeintheWoods) : 5/11/2011 7:20:37 PM (GMT-6)


aguywithuc
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   Posted 5/11/2011 10:02 PM (GMT -6)   
BabeintheWoods said...

One way to determine if you are deficient might be (just guessing here) to get your blood levels of homocysteine tested.


I had that confused with C-Reactive which plunged from 52 to .47 both are heart health indicators

C-Reactive 52 0.47

Homocysteine 7.9 on 7-10 scale in 2009. Smack dab in the middle and only have one value, hospitals do not bother checking it.

It is not in my friday lab bundle from directlabs.com so I will have to get it mid summer when I will be watching C-Reactive and Platelet count.

C-Reactive protein: Used to assess the risk of cardiovascular and peripheral vascular disease.

Homocysteine: commonly used as a screen for people at high risk for heart attack or stroke. It may be useful in patients who have a family history of coronary artery disease but no other known risk factors.

Sara14
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Date Joined Mar 2007
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   Posted 1/14/2012 2:16 PM (GMT -6)   
Has niacin helped anyone? I watched a documentary last night that said high levels of niacin have been shown to help depression so I was looking into that.
27 years old; diagnosed pancolitis March 2007

Asacol, 6 tabs, 2xday; Rowasa once a week; Canasa as needed for flares; Ortho Tri-Cyclen; Singulair, Allegra, Omnaris nasal spray; multivitamin; allergy shots....too many medicines!

funkyskank
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Date Joined Sep 2008
Total Posts : 44
   Posted 6/7/2013 3:02 AM (GMT -6)   
Interesting story about niacin and UC http://health.groups.yahoo.com/group/isribd/message/11

deltaforce
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Date Joined Jun 2010
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   Posted 12/19/2013 4:56 AM (GMT -6)   
I was wonder if Babe or Imagerderner2 or anybody else is still taking Niacin (with flush) and have anything to report back, i.e. if it worked, did not work, backfired etc.

Thanks in advance.
Dx 03/2007, left sided UC.
Sulfasalazine 1.5gm, Imuran, 50mg, Vit. B12, 1mg, Multivitamin, 1 tablet, Fish oil 2400mg , Vit D 2000 IU, Benebiotics 2caps, Folic acid 1mg. Canasa

Verapamil 320mg for migraine,
Nabumetone 750mg as an abortive, so far so good with GI side effects.
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BabeintheWoods
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   Posted 12/19/2013 7:58 AM (GMT -6)   
Never took niacin enough alone to get the flush but always take B complex and other supplements. Monitor my blood work regularly. My LDL cholesterol is low, HDL is high and strangers sometimes compliment me for my full head of hair. Avoiding trans fats and high fructose corn syrup seems to keep my cholesterol in check. The best way to control triglycerides is avoiding excess sugar and taking fish oil.

But when I was flaring my blood counts were so bad from bleeding, etc., that I was referred to an oncologist to check for lymphoma. But everything returned back to normal when my flare ended.
Male/62 DX IBD in Feb08. No meds, allergic to Mesalamine. Remission since Mar2010. Psyllium seed mixed with VSL3 is very helpful. Several Culturelle a day firms up stools. Food diary instead of SCD or Paleo.

Probiotics, Fish oil, multivitamin, extra D3, K2, E complex, magnesium, boswellia, curcumin, DGL, potato starch, glutamine.
Resistant Starch and lots of fruit & vegetables (but no cruciferous), No Gluten, no soda, no HFCS, no xylitol or sorbitol, no trans fat, no shellfish, no carrageenan, no GMO foods saturated with Roundup.
Nature created all of the locks, therefore Nature has all of the keys

imagardener2
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Date Joined Jan 2010
Total Posts : 3493
   Posted 12/19/2013 9:16 AM (GMT -6)   
I didn't take niacin for very long and can't remember why I quit 2.5 years ago (generally increased UC symptoms make me quit new supplements).

My current homocysteine levels are normal but my cholesterol could be lower.
Current diet=modified Paleo+potatoes, white rice, hard cheese
In remission April 2010 after 10 years of UC with no remission ever
gluten-free (bleeding stopped) and dairy-free (less gas) started remission path+food diary
current meds=(9)Balsalazide daily (mesalamine enema only when needed)
Rx meds have never worked for me except for mesalamine enema
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