UC and kidney stone

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deltaforce
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Date Joined Jun 2010
Total Posts : 1995
   Posted 5/17/2011 4:55 PM (GMT -7)   
Hello folks,

I was diagnosed with kidney stone in Feb and had to go to the ER after excruciating abdominal pain. It popped up again last week, got admitted in the hospital and now its removed. Another tiny stone in the kidney will be removed tomorrow.

During discussion with the urologist, he mentioned that UC patients are more prone to kidney stones. He didn't know why. Until then, I thought my kidney stone as a side effect of Topamirate that I am taking for my migraine.

I wonder if anyone else has heard this.

Thanks in advance.

Red_34
Forum Moderator


Date Joined Apr 2004
Total Posts : 22145
   Posted 5/17/2011 9:04 PM (GMT -7)   
I've never had stones but my GI also told me that kidney stones are a complication of having Uc. From what I have read, there is no known cause as of yet why this happens but one theory is the wacky immune system.

"about half of patients with ulcerative colitis have mild symptoms. Ulcerative colitis may also cause problems such as arthritis, inflammation of the eye, liver disease (fatty liver, hepatitis, cirrhosis, and primary sclerosing cholangitis), osteoporosis, skin rashes, anemia, and kidney stones. No one knows for sure why problems occur outside the colon. Scientists think these complications may occur when the immune system triggers inflammation in other parts of the body. These problems are usually mild and go away when the colitis is treated."
SHERRY
Moderator-Allergies/Asthma and Alzheimer's, Co-moderator-UC
~Left sided Uc-'92**Unable to tolerate ALL mesalamines**
Colazal(9 daily)/6mp(50mgs)/Bentyl-Prilosec~allergies-Singulair/Zyrtec~Reynauds~OA-Tylonel Arthritis~Scoliosis~Sacroilitis~Dry eye-Restasis~GAD-Klonopin (.25mgs)~Rosacea-Metrogel/Elidel~IBS~Diverticulosis~Fibromyalgia

quincy
Elite Member


Date Joined May 2003
Total Posts : 25828
   Posted 5/17/2011 9:08 PM (GMT -7)   
I don't hear of many on here with kidney stones...in all my years here. So, I don't think it's a common thing. Prone....subjective maybe, depending on meds possibly. Truthfully, I don't know a lot about them. My neighbour had them (female), and suffered greatly and as you have, she had them removed surgically.

She had been on mega pain meds, however. Maybe some people are more prone, but she doesn't have UC. Seems to be OK at this point.

Another friend had them after her son was born and at the same time she was diagnosed with autoimmune hepatitis. She had them shattered/blasted with laser and passed them.

It's good you've had one removed and soon to be the other. I'm interested in exactly how the procedure was done.

Hope you continue to feel better. Has your UC been OK through all of this?

q
*Heather* I give suggestions, do with them what you will.
Status: ...Asacol 3 @ 2x daily; Salofalk enema @ 3rd night (nightly/ flares, tapered/maintenance)
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol 20mg as needed; Zantac 150mg; Pulmicort/Airomir (asthma);Effexor XR 37.5 (depression)
~vitamins/minerals/supplements; Probiotics....(RenewLife Ultimate Flora Critical Care+Primadophilus Reuteri capsules @ bedtime)
~Metamucil capsules 6 twice daily with meals; Vitamin D 4500 IU
~URSO for PBC(or PSC?) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS" worth it !!!

Alinus
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Date Joined May 2010
Total Posts : 593
   Posted 5/17/2011 11:00 PM (GMT -7)   
my Gi told me it's a common thing among UC people, caused by inflamation. she also explained me the proces, something about dead leucocytes and oxidation but i've forgot all about it.

i do have them, from about 10 years. small. yet...

my dad, who had UC also, had them too. i remember that once in 2-3 years he would be admited in hospital with big pains to get read of them.
Rectocolitis .Symptoms since about 2002. Currently in remission (latest C-scope done in feb 2011).
Ankylosing Spondylitis as a gift from rectocolitis. Symptoms since about 2002. Fragile remission from march 2011.
Highly restricted SCD Diet since feb 2010. Raw carrots, Celery, Beet root, peppers, Chicken, Tuna, Turkey, Swiss cheese, Dry red wine.
Mesalasine 1500 mg/day. Centrum Multivit. Vit D.

thatfield
Veteran Member


Date Joined Jul 2008
Total Posts : 822
   Posted 5/18/2011 7:42 AM (GMT -7)   
Yes, I had one - I did not know that UC can be linked to kidney stones. Good information!
36 yrs female
Dx 2006 right after the birth of my daughter
Had baby #2 in August 2010!
Imuran 150mg

barnsbury
Regular Member


Date Joined Jan 2006
Total Posts : 443
   Posted 5/18/2011 11:35 AM (GMT -7)   
Yes, I had a very painful kidney stone and I have UC. I needed surgery and a stent put in. I was told to drink lots of water to lessen the chances of getting another one.

deltaforce
Veteran Member


Date Joined Jun 2010
Total Posts : 1995
   Posted 5/18/2011 2:38 PM (GMT -7)   
Today, the urologist just ripped me off of my co-pay and plus whatever he charges me on top of that. I am so so annoyed.

I was originally told that stent will be removed but now he says that the small kidney stone should be removed by lithotripsy first, my system should pass that broken stone and then stent should be removed. This info could also have been given at the time of hospital discharge. There was no need for him to tell me schedule an appointment just to tell me this.

The reason UC patients are more prone to kidney stone is because their system absorbs more oxalates from the gut which forms calcium salt in kidney and forms stone at the end.

@ barnsbury,
the stent can be kept inside your system for not more than 3 months. I hope you know that. Doesn't it bother you? I can't wait to get rid of it..

NickiM23
Regular Member


Date Joined May 2011
Total Posts : 48
   Posted 5/18/2011 5:48 PM (GMT -7)   
Yup my doctor has told me this and I've had two
Diagnosed w/ UC at age 9. I've pretty much been on every diet and drug (except Remicade).
Remission from 2003-2010
**Current flare**
Medication: prednisone 20mg, cortiform enemas, waiting to get in for my first Remicade treatment
Considering a J-pouch....

barnsbury
Regular Member


Date Joined Jan 2006
Total Posts : 443
   Posted 5/19/2011 1:22 AM (GMT -7)   
Deltaforce - Yes, I had it removed a week after I had it put in!  Like you, I was desperate to get rid of it.  The urologist was happy to let the stent stay in for 3 weeks, but I begged him to remove it, and luckily he did after a week. That was the worst week.  Nothing but pain, blood in my urine and urinary incontinence.  Stents are vile.
 
Hope you get yours out soon, keep us updated with any news. I really do feel for you.
 
Take care
Pan Ulcerative Colitis since July 2000

Azathioprine 125mg
Colazide 6.75g
Vedolizumab MLN0002 Drug Trial (since January 2010)

OFF Steroids after 8 years straight! :)

aguywithuc
Veteran Member


Date Joined Jun 2010
Total Posts : 2550
   Posted 5/19/2011 4:43 PM (GMT -7)   
I have not had that joy yet. I did have a UC-related stroke and they gave me Topamirate for my headaches but I never took it after reading online about it and ended up getting off the blood thinner 3 months early too.

My kidney number have been high but they finally came down a bit when I backed off the high protein diet and now my liver numbers shot from 30 to 80 yet I have not had a drink in 9 months. Really puzzled about that one.

barnsbury
Regular Member


Date Joined Jan 2006
Total Posts : 443
   Posted 5/20/2011 2:47 AM (GMT -7)   
aguywithuc - I also have a high liver function count. It is also puzzling the dr's. I am due to have a liver biopsy to get to the root of the problem. We suspect it is the azathioprine that is the culprit. Are you on aza?
 
Best wishes
Pan Ulcerative Colitis since July 2000

Azathioprine 125mg
Colazide 6.75g
Vedolizumab MLN0002 Drug Trial (since January 2010)

OFF Steroids after 8 years straight! :)

deltaforce
Veteran Member


Date Joined Jun 2010
Total Posts : 1995
   Posted 5/20/2011 7:33 AM (GMT -7)   
@ aguywithuc,

What do you mean by kidney numbers?
If your liver numbers are funny and you are on Aza, most likely its Aza thats playing a role. I am on Aza and sometimes my numbers are funny too but unless they are far awkward, my GI doc from Sweden has always disregarded it.

One thing I am very stunned from your post. How can you live with your headache? I have migraine and I am on 125mg topamirate and it still doesn't work. Its making my life hell. My insurance is still unclear about covering pre-existing condition so I can't see a neurologist yet but till then I am seriously suffering and here you are, not taking medicine at all. Please let me know your tip on management, may be I can relieve my pain. I can relieve my pain with Ibuprofen but it leads to intestinal bleeding and then thats another hell...

Seriously folks, this is USA and I wonder how this medical system is messed up and nobody is standing up to fix it. This country needs to learn lessons from other countries where the system works and people get the treatment they need without 'suffering'. It is so so frustrating, can't really put it in words :(

aguywithuc
Veteran Member


Date Joined Jun 2010
Total Posts : 2550
   Posted 5/20/2011 10:42 PM (GMT -7)   
deltaforce said...
@ aguywithuc,

What do you mean by kidney numbers?
If your liver numbers are funny and you are on Aza, most likely its Aza thats playing a role. I am on Aza and sometimes my numbers are funny too but unless they are far awkward, my GI doc from Sweden has always disregarded it.

One thing I am very stunned from your post. How can you live with your headache? I have migraine and I am on 125mg topamirate and it still doesn't work. Its making my life hell.


It was hell. I was unable to recall a lot of technical detail as I interviewed for a new contract knowing I needed to pay the 10k back from the 64k hospital bill. I finally got a break. They had interviewed me in the spring but I did not want the job. 2nd time around in the fall they had already checked me out in a 4-hour gang interview so it was more about other aspects of the 'fit'. So I took it because I needed to get back in the saddle again. They were saying the project was already behind schedule and they needed someone who could not only hit the dates but make up lost time. I began working 6 weeks post-stroke from 8:00 am until midnight at a computer all day building new systems for 16 hours straight. By 3:00 each day the back of my head felt like someone had shot me with a gun. I might have been leaning in too much and it could have been positional but to frankly answer you question that is when I would start my daily Vicodin allotment right then and there. It was the Vicodin that was hampering my recall ability during interviews. It was the Vicodin that helped with the pain. After 3 months of blood thinner I wanted off, but that meant off Vicodin too. MRI/MRV said it was totally resolved and I came off Vicodin. This was January I had worked straight thru the holidays without one day off. I missed my vicodins but I wont go back unless I need to. I am so much more productive now and my new gig has a ton of responsibility. The other people quit I am handling it all.

Too bad because the vicodin, well it made it like I did not even have UC. It was perfect for UC.

aguywithuc
Veteran Member


Date Joined Jun 2010
Total Posts : 2550
   Posted 5/20/2011 10:49 PM (GMT -7)   
deltaforce said...
@ aguywithuc,

What do you mean by kidney numbers?


Liver

AST 34 73 31 43 18 35 40 80 --> last week
ALT 63 57 21 37 30 30 37 55 --> last week

April 2008 I was nearly this high with 73,57 but just 3 months ago I was way lower at 35,30

Kidney

Creatinine 1.4 1.2 1.3 1.4 1.4 1.6 1.4 1.6 1.56 1.58
eGFR 60 58 53 55 46 48 51
Bun 27 13 42 13 19 32 22 13 15 27 22
Protein 7.2 8.1 7 7 6.6 6.2 6.4 6
Uric Acid 9.2 5.5

Creatine is always high, just hoping it is stable ( Low fat, muscular, high protein diet )
eGFR is simply your age divided by creatinine, unless african american then they adjust since they are more muscular
BUN coming down...but was 27 long ago and recently last month
No long history for the uric acid, just know it came down hard and fast by backing off constant protein intake

I take sulfasalazine, VSL#3, curcumin, boswellia, spinach, fish and have been in remission since last summer flare

aguywithuc
Veteran Member


Date Joined Jun 2010
Total Posts : 2550
   Posted 5/20/2011 10:51 PM (GMT -7)   
barnsbury - how high are your numbers ? I think mine are from 'White Flood' I was starting to consume too much.

barnsbury
Regular Member


Date Joined Jan 2006
Total Posts : 443
   Posted 5/21/2011 2:45 AM (GMT -7)   
aguywithuc - I only have my ALT blood results to hand:  54  88  104  102  61
 
 
 
 
Pan Ulcerative Colitis since July 2000

Azathioprine 125mg
Colazide 6.75g
Vedolizumab MLN0002 Drug Trial (since January 2010)

OFF Steroids after 8 years straight! :)

aguywithuc
Veteran Member


Date Joined Jun 2010
Total Posts : 2550
   Posted 5/21/2011 7:19 AM (GMT -7)   
barnsbury said...
aguywithuc - I only have my ALT blood results to hand: 54 88 104 102 61


Wow that is not much higher than mine and your doctor wants to obtain a biopsy ? What does that entail ?

I think my liver did not like the new copper supplement that comes with zinc.

Looks there is a non-invasive test :

There is now a validated and patented combination of 6 of these markers as non-invasive biomarker of fibrosis (and so of cirrhosis) : FibroTest.[11]

en.wikipedia.org/wiki/Cirrhosis

Lab findings
The following findings are typical in cirrhosis:

Aminotransferases - AST and ALT are moderately elevated, with AST > ALT. However, normal aminotransferases do not preclude cirrhosis.
Alkaline phosphatase - usually slightly elevated.
Gamma-glutamyl transferase – correlates with AP levels. Typically much higher in chronic liver disease from alcohol.
Bilirubin - may elevate as cirrhosis progresses.
Albumin - levels fall as the synthetic function of the liver declines with worsening cirrhosis since albumin is exclusively synthesized in the liver

There is now a validated and patented combination of 6 of these markers as non-invasive biomarker of fibrosis (and so of cirrhosis) : FibroTest

Seems my other liver marker are just fine:


AST 34 73 31 43 18 35 40 80
ALT 63 57 21 37 30 30 37 55
ALP 57
GGT 8
Albumin 4.3
Sodium 139
Glucose 69 87 79 86 142 125 83 90 83 83


Going to get in to see the GP and retake the CBC after laying off the copper/zinc pills.

Post Edited (aguywithuc) : 5/21/2011 8:41:40 AM (GMT-6)


barnsbury
Regular Member


Date Joined Jan 2006
Total Posts : 443
   Posted 5/21/2011 9:33 AM (GMT -7)   
I also have high bilirubin for many years. I have been diagnosed with Gilberts Syndrome since 2005. But, apparently that only causes high bilirubin, and not high ALT.
 
For the liver biopsy - I will have a long needle inserted through my hip into the liver, which will then take a biopsy.  The procedure itself does not take very long, but I have been told that I have lie on my side and not move at all for 4 hours afterwards, to reduce the risk of internal bleeding.
 
Best wishes
Pan Ulcerative Colitis since July 2000

Azathioprine 125mg
Colazide 6.75g
Vedolizumab MLN0002 Drug Trial (since January 2010)

OFF Steroids after 8 years straight! :)

Dunia77
Regular Member


Date Joined May 2011
Total Posts : 149
   Posted 5/22/2011 12:40 PM (GMT -7)   
Hi. You're talking kidney stones. And I just wonder - maybe a little advice from you.
I'm on predn for the first time. Starting on 30mgs, for almost 3 weeks, tapering every week or so, now on 15mgs. Everything seems to be fine, except I have a flank pain, mostly on my back, sides, for some time - under my rib cage. It started on right side, for one or two days I took some ibuprofen for pain. Now it seems that right side is almost back to normal but left is painfull. And the pain is fluctuating during the day, night.
Many years ago I had some issues with 'sand in kidneys', but it's been ages since any urinal tract problems, ages before I was Dx with UC 6 years ago. As my doc put me on Prend without asking any qustions about my health (even though he has my history on file), and I wasn't aware of the side effects then, I just started taking Predn. And now this flank pain... Could it be something going on with kidneys? Or maybe it's the effect of tapering every 5-7 days?
Moreover, in Feb I started taking Calcium and Vit D supplement, as my blood work came back with vit D insufficiency. My GI said it's ok if I take that supplement while on Predn. So I've been taking like 150% daily dose (I have to change mz signature), as I'm not a very dairy person, not at all. Could it have some effect on the kidneys in such a short time?
Could it be something bad going on? I have no other urinary symptomps - should there be any if the pain would be from stones? With sand I alwazs had some kind of infection going on, like blood in urine, low grade fever, etc. So now, I wonder, that it could be effect of weaning of the predn?
I'm asking about it, because right now I'm abroad for quite a long time. Have my insurance card with me, of course, and they would reimburse me for any local treatment according to my plan. But, to be honest, I'd rather go to doctor if there really is something going on.
Thanks for your advice.
UC diagnosed 2005
Without major flare ups until April 2011 (over two years without ANY meds)
Currently: Prednisone (15mg/day, tampering every 5-7 days), Lialda 4 tabs/day
OTC: Multivitamin, Calcium plus VitD (double daily dose), potassium (double daily dose), Primadophilus Reuteri

Post Edited (Dunia77) : 5/22/2011 12:47:30 PM (GMT-6)


Alinus
Veteran Member


Date Joined May 2010
Total Posts : 593
   Posted 5/22/2011 2:16 PM (GMT -7)   
@ dunia
i believe your pain comes from your colon. it is possible also that you have some arthitic pain since you say it goes off using ibuprofen.
i've had this kind of pain you've described. if you have a spastic colon you will feel every beat of the boll comming through it.

i don't think it's the kidney, but an urine exam will clear this out probably. have a chat with your GI about this kind of pain, if she/he believes it's artritis you will be send to see a rheumy probably. If not, maybe some muscle relaxants for your gut will do it for you.

good luck
Rectocolitis .Symptoms since about 2002. Currently in remission (latest C-scope done in feb 2011).
Ankylosing Spondylitis as a gift from rectocolitis. Symptoms since about 2002. Fragile remission from march 2011.
Highly restricted SCD Diet since feb 2010. Raw carrots, Celery, Beet root, peppers, Chicken, Tuna, Turkey, Swiss cheese, Dry red wine.
Mesalasine 1500 mg/day. Centrum Multivit. Vit D.

deltaforce
Veteran Member


Date Joined Jun 2010
Total Posts : 1995
   Posted 5/24/2011 4:20 PM (GMT -7)   
Now that its confirmed that UC and kidney stone has got connection, is anyone taking any medication to reduce oxalate absorption? If yes, what is it?
Diagnosed March 2007 with left sided UC at the age of 30.
Currently on,
Colazal 9 daily,
Imuran, 100mg + 50mg
Vit. B12, 1mg
Multivitamin, 1 tablet daily
Fish oil 1200mg daily
Vit D 2000 IU daily.

Topamax 50mg + 75mg daily for migraine with aura. Migraine appears once a week, Ibuprofen 400mg is the only solution. Looking for alternatives.

Alinus
Veteran Member


Date Joined May 2010
Total Posts : 593
   Posted 5/24/2011 10:43 PM (GMT -7)   
i take Urinex from time to time.
Rectocolitis .Symptoms since about 2002. Currently in remission (latest C-scope done in feb 2011).
Ankylosing Spondylitis as a gift from rectocolitis. Symptoms since about 2002. Fragile remission from march 2011.
Highly restricted SCD Diet since feb 2010. Raw carrots, Celery, Beet root, peppers, Chicken, Tuna, Turkey, Swiss cheese, Dry red wine.
Mesalasine 1500 mg/day. Centrum Multivit. Vit D.
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