Well, POOH! (Not literally)

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BelleyAche
Regular Member


Date Joined Nov 2010
Total Posts : 117
   Posted 7/25/2011 5:01 PM (GMT -7)   
Hi all,
 
I have been reading but not posting as things have been pretty good with me.  Last week I went to my MD for my regular blood testing (thyroid, cholesterol, sugar, etc).  Today I get a call saying I have low hemoglobin, 10.2 and my hemocrit is low too.  Also my kidney function was high, producing protein in my urine.  Turns out I have to now go tomorrow for more blood tests like B12 and iron def test, get a huge jug to pee in for the next 24 hours and get the poo cards too!  I have been feeling really well for about 3 weeks, my BMs are more formed, I don't see any blood. 
 
I did call my GI office and the nurse there said my Apriso could be affecting my kidneys.  They have never done a test since I went on it a year ago to check my levels, so I am hoping this can be taken care of.  My niece who is a nurse says it only makes sense that the UC and the constant pooping could produce the low blood count ( I was bleeding about a month ago), but of course I am a nervous wreck.
 
On the upside my cholesterol was 158, go me! 
 
Any ideas or has anyone else become anemic because of UC?  Has Apriso affected anyone else?
50/f DX with pancolitis 6/2010 been flaring ever since it seems
Currently on:
Apriso 4 daily
Rowasa 1 nightly
Synthroid 75 mcg

Red_34
Forum Moderator


Date Joined Apr 2004
Total Posts : 22148
   Posted 7/25/2011 7:11 PM (GMT -7)   
I guess you were blindsided huh? I've had anemia plenty of times over the years due to Uc, however, it was always accompanied with visible blood.

I can't comment on Apriso since I can't take it but I was on Asacol for 12 years, but never had an issue with it affecting my kidneys.

I hope everything turns out okay!
SHERRY
Moderator-Allergies/Asthma and Alzheimer's, Co-moderator-UC
~Left sided Uc-'92**Unable to tolerate ALL mesalamines**
Colazal(9 daily)/6mp(50mgs)/Bentyl-Prilosec~allergies-Singulair/Zyrtec~Reynauds~OA-Tylonel Arthritis~Scoliosis~Sacroilitis~Dry eye-Restasis~GAD-Klonopin (.25mgs)~Rosacea-Metrogel/Elidel~IBS~Diverticulosis~Fibromyalgia

quincy
Elite Member


Date Joined May 2003
Total Posts : 25828
   Posted 7/25/2011 10:58 PM (GMT -7)   
Sheesh, that sucks when you're feeling good and all.

It's good you're having more testing done..all of which you mentioned.


Yes, 5ASA meds can cause changes in kidney function...I believe Beth is one who had serious kidney issues from 5ASA.

I'm checked twice a year for kidney enzymes.
I've taken 5ASA for over 22 years, hopefully that can continue without any problems.

I've never had anemia from any of the bleeding, which was weird considering it (to me) was a heck of a LOT!

Keep us posted as to the results...

q
*Heather* I give suggestions, do with them what you will.
Status: ...Asacol 3 @ 2x daily; Salofalk enema @ 3rd night (nightly/ flares, tapered/maintenance)
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol 20mg as needed; Zantac 150mg; Pulmicort/Airomir (asthma);Effexor XR 37.5 (depression)
~vitamins/minerals/supplements; Probiotics....(RenewLife Ultimate Flora Critical Care+Primadophilus Reuteri capsules @ bedtime)
~Metamucil capsules 6 twice daily with meals; Vitamin D 4500 IU
~URSO for PBC(or PSC?) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS" worth it !!!

canadagal
Veteran Member


Date Joined Jan 2011
Total Posts : 599
   Posted 7/26/2011 11:25 AM (GMT -7)   
the whole year i was flaring (bleeding) I needed iron tablets daily to maintain an acceptable level of iron. easy enough problem to take care of it that is all it is. when I'm stable... iron level is good. some of us ladies (in particular) just done enough iron rich foods to cover the monthly losses...

good luck with the rest of the tests
38yr old female
first symptoms 2006, UC diagnosis 2007, solid remission for 3 years then flare from Jan 2010 til Jan 2011.
Current Meds: 3 Mezavants/day (3.6g),
Other: multivitamins, sunflower seeds since Dec. 2010

In remission since mid Jan. 2011! : )

BelleyAche
Regular Member


Date Joined Nov 2010
Total Posts : 117
   Posted 7/26/2011 3:12 PM (GMT -7)   
Update* My Dr. said no more Apriso. Ran lots of tests today, including a 24 hour urine and stool cards. Informed GI about the increased protein levels and she said if I suffer colitis symtoms I will have to go on Remicade. Aren't there other drugs I could try before that? Dr. just called and I also have a UTI, never had one in my life. She is putting me on CIPRO. I am not sure this is a good thing either with colitis, but have read it helps some here. I didnt even know I had a UTI, wonder if that could be part of the reason for the protein in my urine??
50/f DX with pancolitis 6/2010 been flaring ever since it seems
Currently on:
Apriso 4 daily
Rowasa 1 nightly
Synthroid 75 mcg

suenew61
Regular Member


Date Joined Feb 2010
Total Posts : 103
   Posted 7/27/2011 3:25 AM (GMT -7)   
Yes the protein in your urine could be caused by the infection.
They should be looking at the urea(BUN) and creatinine concentrations in your blood to check out your baseline renal function. It depends on how raised these are - and what your GFR(glomerular filtration rate) calculates to that will show if your kidneys have been affected. You could try asking about Aza or 6MP as maintenance drugs because as a pancolitis it may be difficult to hold onto remission without some form of medication/supplement/diet control. Especially if you are going onto an antibiotic you might want to think about getting onto a probiotic.
Sue
Daughter(18) diagnosed severe pancolitis Nov 2009
Off all mesalazine following acute pancreatitis
6MP(25mg/day) SCD, Vitamin D,
Multivitamin, Udo's Choice Super 8 Probiotic
FSC Ginger, Boswellia & Curcumin
Enerex CoQ10 (enteric with B6 and phosphatidylcholine)
Looking into non-IgE delayed allergy response

BelleyAche
Regular Member


Date Joined Nov 2010
Total Posts : 117
   Posted 7/27/2011 7:09 AM (GMT -7)   
Thanks Sue, I will check into that!
50/f DX with pancolitis 6/2010 been flaring ever since it seems
Currently on:
Apriso 4 daily
Rowasa 1 nightly
Synthroid 75 mcg

quincy
Elite Member


Date Joined May 2003
Total Posts : 25828
   Posted 7/27/2011 9:54 AM (GMT -7)   
 
This might help in the way of why protein is in the urine, not to asy this is what it is....and other tests you might ask the doc about.  As well....search on that site, it explains things well.
 
q
*Heather* I give suggestions, do with them what you will.
Status: ...Asacol 3 @ 2x daily; Salofalk enema @ 3rd night (nightly/ flares, tapered/maintenance)
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol 20mg as needed; Zantac 150mg; Pulmicort/Airomir (asthma);Effexor XR 37.5 (depression)
~vitamins/minerals/supplements; Probiotics....(RenewLife Ultimate Flora Critical Care+Primadophilus Reuteri capsules @ bedtime)
~Metamucil capsules 6 twice daily with meals; Vitamin D 4500 IU
~URSO for PBC(or PSC?) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS" worth it !!!

BelleyAche
Regular Member


Date Joined Nov 2010
Total Posts : 117
   Posted 7/27/2011 11:52 AM (GMT -7)   
Thanks Q, This morning I returned the "jug" and the stool cards and I gave about a quart of blood yesterday. I am also on Cipro for a urinary tract infection, my first ever. I was told that it could be the culprit too. I am somewhat concerned that the Cipro may induce a flare, even though I have read where it has actually helped also. We shall see. Wish me luck!

:)
50/f DX with pancolitis 6/2010 been flaring ever since it seems
Currently on:
Apriso 4 daily
Rowasa 1 nightly
Synthroid 75 mcg

quincy
Elite Member


Date Joined May 2003
Total Posts : 25828
   Posted 7/28/2011 2:49 AM (GMT -7)   
I hope you get answers and that the Cipro helps. I would suggest you make sure you take probiotics.

Keep us posted.

q
*Heather* I give suggestions, do with them what you will.
Status: ...Asacol 3 @ 2x daily; Salofalk enema @ 3rd night (nightly/ flares, tapered/maintenance)
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol 20mg as needed; Zantac 150mg; Pulmicort/Airomir (asthma);Effexor XR 37.5 (depression)
~vitamins/minerals/supplements; Probiotics....(RenewLife Ultimate Flora Critical Care+Primadophilus Reuteri capsules @ bedtime)
~Metamucil capsules 6 twice daily with meals; Vitamin D 4500 IU
~URSO for PBC(or PSC?) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS" worth it !!!

BelleyAche
Regular Member


Date Joined Nov 2010
Total Posts : 117
   Posted 7/31/2011 7:42 AM (GMT -7)   
Hey from the hosptial :(

Update..... after having many many labs and tests this week I have landed myself in the hospital to figure out why my creatnine levels got so high. They called in a kidney specialist who says so far all tests indicate it's a reaction to Apriso. They are putting me on IV fluids to flush the kidneys and also a semi-steroid. As of this morning my levels are slowly coming down. Hopefully this is the problem.

As for others on Apriso make sure you get your levels checked regularly as my GI never did in a year on Apriso.

Hoping to break out of here tomorrow!

Belley
50/f DX with pancolitis 6/2010 been flaring ever since it seems
Currently on:
Apriso 4 daily
Rowasa 1 nightly
Synthroid 75 mcg

quincy
Elite Member


Date Joined May 2003
Total Posts : 25828
   Posted 7/31/2011 9:52 AM (GMT -7)   
Oh no...but it's better you're there to find out for sure what's going on.

If it's the Apriso, it'll also be the Rowasa.

I agree regarding getting creatine levels checked..
q
*Heather* I give suggestions, do with them what you will.
Status: ...Asacol 3 @ 2x daily; Salofalk enema @ 3rd night (nightly/ flares, tapered/maintenance)
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol 20mg as needed; Zantac 150mg; Pulmicort/Airomir (asthma);Effexor XR 37.5 (depression)
~vitamins/minerals/supplements; Probiotics....(RenewLife Ultimate Flora Critical Care+Primadophilus Reuteri capsules @ bedtime)
~Metamucil capsules 6 twice daily with meals; Vitamin D 4500 IU
~URSO for PBC(or PSC?) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS" worth it !!!

imagardener2
Veteran Member


Date Joined Jan 2010
Total Posts : 3823
   Posted 7/31/2011 11:30 AM (GMT -7)   
Hope you feel better soon.
In remission April 2010 after 10 years of UC with no remission ever
Jan 2010 began SpecCarbDiet (modified to remove dairy, fruit & juices,)
Gluten-free=bleeding stopped in 3 days, 95% remission in 5.5 months on SCD
SCDiet: Gluten/grain-free, starch-free, low carb, honey as sweetener
(9)Balsalazide+(6)Citrucel, mesalamine enema as needed
Spinach & sunflower seeds daily, (1) VSL#3 nightly

BelleyAche
Regular Member


Date Joined Nov 2010
Total Posts : 117
   Posted 7/31/2011 11:59 AM (GMT -7)   
Yes and I loved Rowasa! I am being released today due to the fluids I have been getting and the prednisone in my IV has lowered my levels. They are still high but controllable at home. I will be going to a new GI but thankfully the prednisone really makes me feel good so I am ok with it short term. She said this time will be really short term and I feel ok GI wise right now.

I just want to warn anyone on Apriso to make sure they are having their kidney function checked regularly. The kidney Dr said she sees it alot with this drug. It helped my UC but almost destroyed my kidneys!

Woo Wooo I am going home:)

Thanks to all you wonderful UC sharers out there, its a horrible disease but you all make more bearable !
50/f DX with pancolitis 6/2010 been flaring ever since it seems
Currently on:
Apriso 4 daily
Rowasa 1 nightly
Synthroid 75 mcg
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