topiramate & IBD

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notsosicklygirl
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Date Joined Dec 2008
Total Posts : 10317
   Posted 8/17/2011 4:16 PM (GMT -6)   
I saw an interesting article that mentioned that this may be a potential treatment for IBD.
 
Does anyone take it?
 
 
They found that an anti-ulcer treatment known as cimetidine was a good match for lung cancer, and a seizure drug topiramate would work against inflammatory bowel disease.

They tested cimetidine on human lung cancer cells -- some in a lab dish and others that were transplanted into mice. Both approaches slowed the cancer cells' growth.

The anti-convulsant drug was administered to rats with bowel disease and was shown to reduce the associated symptoms of diarrhea, ulcers and colon damage.


Co-moderator: Ulcerative Colitis
Diagnosed with Pancolitis & Migraines. Battling Extreme Exhaustion
Currently: Asacol (2300mg) + 6mp (50mg) + Pristiq (50mg) + Zantac (150mg) + Canasa (1g PM) + cerazette

IamCurious
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   Posted 8/17/2011 4:51 PM (GMT -6)   
Great information, thanks.

Cimetidine is more known as the brand name Tagamet for heartburn. Topiramate is known as the brand name Topamax and originally for Epilepsy. But I am worried that they will not be prescribed very often because, just like LDN, they are now generic drugs which means very little profit potential for Big Pharma.

Sibby
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Date Joined Apr 2010
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   Posted 8/17/2011 5:01 PM (GMT -6)   
Wouldn't it make sense to take a drug that helps with ulcers when one of the symptoms of IBD are ulcers? I thought of that instantly when I was diagnosed, but never thought to ask anyone.
22 · F · Ont, Canada
Inactive left-sided UC · Remission!
Asthma, seasonal allergies
March 2011 scope indicates 15% inflammation
Salofalk made symptoms worse
Imuran, 100 mg · Alesse · Folic acid, 5 mg · Multi-vitamin, Vit. B, C, D, Calcium
Avoids: red meat, alcohol, high fat, fried, salt, sugar, dairy
Can have: fruits, vegetables, white meat, wheat
Trial and error: Benefiber

InSoFla
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Date Joined Jan 2011
Total Posts : 4679
   Posted 8/17/2011 5:25 PM (GMT -6)   
Thanks for posting this.
Unfortunately, like Babe said:...now generic drugs which means very little profit potential for Big Pharma.
 
All the big pharma is concerned about is profits, not our health!

Dx with UC in Sept. 2010.Tried various Mesalamine enemas/suppos/pills with Prednisone for several rounds without any help.Diet consists of mostly only protein: protein shakes w/almond milk, Liquid Minerals& Vitamins,Maca powder,L-Glutamine 15g, D-Ribose 5g, chia seeds,5-Loxin.VSL#3,K2,VIt. D3 100,000 IU every 10 days.Canasa suppos. as maintenance. But Transdermal LDN is working!!

notsosicklygirl
Forum Moderator


Date Joined Dec 2008
Total Posts : 10317
   Posted 8/17/2011 5:34 PM (GMT -6)   
I agree about the big pharma situation. There is no incentive to do testing with old drugs because there isn't much money to be made.

I recently started Pristique for migraine prevention and my IBD has calmed down. I am not sure if it is related.
Co-moderator: Ulcerative Colitis
Diagnosed with Pancolitis & Migraines. Battling Extreme Exhaustion
Currently: Asacol (2300mg) + 6mp (50mg) + Pristiq (50mg) + Zantac (150mg) + Canasa (1g PM) + cerazette

InSoFla
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Date Joined Jan 2011
Total Posts : 4679
   Posted 8/17/2011 5:48 PM (GMT -6)   
 
That's great news about the Pristiq; I am so glad for you :-) .
Dx with UC in Sept. 2010.Tried various Mesalamine enemas/suppos/pills with Prednisone for several rounds without any help.Diet consists of mostly only protein: protein shakes w/almond milk, Liquid Minerals& Vitamins,Maca powder,L-Glutamine 15g, D-Ribose 5g, chia seeds,5-Loxin.VSL#3,K2,VIt. D3 100,000 IU every 10 days.Canasa suppos. as maintenance. But Transdermal LDN is working!!

Sibby
Veteran Member


Date Joined Apr 2010
Total Posts : 1239
   Posted 8/17/2011 5:50 PM (GMT -6)   
Couldn't agree more with you all.

Insofia, definitely true, especially if those drugs cause side effect that may need to be counteracted with other medications also.

But at least there's a study out there that may give us another option.
22 · F · Ont, Canada
Inactive left-sided UC · Remission!
Asthma, seasonal allergies
March 2011 scope indicates 15% inflammation
Salofalk made symptoms worse
Imuran, 100 mg · Alesse · Folic acid, 5 mg · Multi-vitamin, Vit. B, C, D, Calcium
Avoids: red meat, alcohol, high fat, fried, salt, sugar, dairy
Can have: fruits, vegetables, white meat, wheat
Trial and error: Benefiber

aguywithuc
Veteran Member


Date Joined Jun 2010
Total Posts : 2479
   Posted 8/17/2011 5:53 PM (GMT -6)   
Sibby said...
Wouldn't it make sense to take a drug that helps with ulcers when one of the symptoms of IBD are ulcers? I thought of that instantly when I was diagnosed, but never thought to ask anyone.


I would not expect it to since stomach ulcers and large intestine ulcers might have nothing to do with one another seperated by many feet of small intestine.

The post above did not make that connection btw it connected cimetidine to lung cancer, topiramate to IDB.

I have a full bottle of topiramate in the kitchen. It was prescribed to me last year by my neurologist after exiting the ICU. I have never taken even one pill after reading about patients complaining it messed with 'word choice' and 'recall'. I had enough trouble with that post-hospitalization when out on technical interviews and did not want to make it any worse. I made the right choice, that 63,500.00 hospital debt is now as good as gone one year later.
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