Exciting Fecal Transplant news.

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baconeggsyum
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Date Joined May 2010
Total Posts : 303
   Posted 10/31/2011 2:28 PM (GMT -6)   
This looks to be a solution! Will try this if I ever hear that "surgery" word.

http://www.eurekalert.org/pub_releases/2011-10/acog-fmt102711.php

Researchers Find Fecal Microbiota Transplantation Effective For Treatment of IBD

With the growing success of fecal transplantation for C.Difficile, researchers have started to explore the effectiveness of this procedure for other serious conditions, such as Inflammatory Bowel Disease (IBD). A second study, "Reversal of Inflammatory Bowel Disease (IBD) with Recurrent Fecal Microbiota Transplants (FMT)," reports successful treatment of severe mixed IBD using recurrent fecal microbiota transplants in three patient cases.

In Case 1, a 19-year old female with an 11-year history of severe IBD and who presented with worsening symptoms including bloody diarrhea and inflamed, ulcerated mucosa , and was considering a colectomy, experienced symptom improvement within several days after receiving FMT. She underwent FMT initially via colonoscopy in July 2009 then by seven daily rectal FMT and 26 weekly FMT's. Follow-up colonoscopy revealed no gross inflammation or edema, with the patient remaining clinically well.

In Case 2, a 23- year old male with a five-year history of steroid and anti-TNFα refractory ulcerative colitis presented with bloody diarrhea more than 20 times per day, anal fissures, severe abdominal pain and joint pain. Pre-FMT colonoscopy – showed severe disease of the left colon with marked cecal inflammation. He underwent daily rectal FMT for the first month, followed by infusions of lessening frequency until he reached 1 FMT/6 weeks. He reported resolution of bleeding 1-2 weeks post-FMT, and formed stool at 1 month post-FMT, resumed work, study activities and regained weight. Colonoscopy at one year showed no histological inflammation but occasional pseudopolyps in the cecum and ascending colon.

In Case 3, a 57-year old female with a nine- year history of 5-ASA antibiotics, probiotics and immunosuppressant refractory ulcerative proctitis in spite of treatment. After training in our clinic, she performed 69, initially daily, then weekly rectal FMT with virtually immediate resolution of diarrhea, bleeding and mucus. Follow-up colonoscopy showed no visible or histological inflammation and she has remained off all therapy for the last four years.

FMT may act as an antagonist to etiological infective agent(s) and aid in re-establishing depleted bacterial species, thereby reversing IBD, according to researchers from the Centre for Digestive Diseases in Australia.

Commenting on the cases of FMT in IBD, lead researcher Thomas Borody, MD, PhD, FACG, said, "the rapid response of FMT and lack of adverse effects make FMT a viable option for treatment-refractory patients and is certainly an added option for those facing colectomy."

[trying to fix scrolling]

Post Edited By Moderator (notsosicklygirl) : 11/25/2012 9:55:43 PM (GMT-7)


fruitgirl
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Date Joined Feb 2009
Total Posts : 6910
   Posted 10/31/2011 2:39 PM (GMT -6)   
Cool! If I'm ever facing surgery (or heck, even the stronger drugs) I'll want to try FT, I'm sure!
Symptomatic remission as of May 2009
Colonoscopy in Oct. 2011 showed no inflammation
Symptoms began in Nov. 2008, about 4 weeks after birth of first child
Diagnosed with pancolitis in Jan. 2009
Apriso (Four 0.375 g pills once daily), Mesalamine enema twice weekly, multivitamin, vitamin D, probiotic
Used prednisone (starting dose 40 mg) to gain remission, tapered off easily

Sibby
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Date Joined Apr 2010
Total Posts : 1248
   Posted 10/31/2011 4:07 PM (GMT -6)   
I'm glad they expanded their patient scale, and it showed improvement in the disease.
22 · F · Ont, Canada
Inactive left-sided UC · Remission!
Asthma, seasonal allergies
March 2011 scope indicates 15% inflammation
Salofalk made symptoms worse
Imuran, 100 mg · Alesse · Folic acid, 5 mg · Multi-vitamin, Vit. B, C, D, Calcium
Avoids: red meat, alcohol, high fat, fried, salt, sugar, dairy
Can have: fruits, vegetables, white meat, wheat
Trial and error: Benefiber

imagardener2
Veteran Member


Date Joined Jan 2010
Total Posts : 3787
   Posted 10/31/2011 6:26 PM (GMT -6)   
Darn I got excited by the title but... the article said that fecal bacteriopathy for IBD is still only being done in Australia, no mention of any other place. The first 3 studies that used FT in the US and Canada were for C. difficile, not any other applications. So that still leaves those of who are interested in it for UC to do-it-yourself.

It makes soooo much sense that there must be some really powerful reason it isn't being studied in the US, the richest nation on earth with so many people it could help. My UC really responds to probiotics which makes me think that good bacteria transplant is ideal. How long do we have to wait?
In remission April 2010 after 10 years of UC with no remission ever
Jan 2010 began SpecCarbDiet (modified to remove dairy, fruit & juices,)
Gluten-free=bleeding stopped in 3 days, 95% remission in 5.5 months on SCD
SCDiet: Gluten/grain-free, starch-free, low carb, honey as sweetener
(9)Balsalazide+(6)Citrucel, mesalamine enema as needed
Spinach & sunflower seeds daily, (1) VSL#3 nightly

Old Mike
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Date Joined Jan 2007
Total Posts : 2628
   Posted 10/31/2011 7:44 PM (GMT -6)   
Can't believe that the doc's in the USA are so resistant to this treatment.
Part of it is liability,injecting fecal material into someones colon has liability. Its not FDA approved so many doc's won't touch it,then there is the not invented here snydrome. Refusal to see the forest for the trees, or they are waiting for a fecal probitic poop pill.
Old Mike

sas
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Date Joined Jan 2005
Total Posts : 532
   Posted 10/31/2011 8:16 PM (GMT -6)   
FT has been the best thing that has ever happened for me.  I really want this studied in clinical trials in the US so that it can become a realistic treatment option for IBD.  Like everything, it will work for some and not for all but for me it has been truly life changing.  I do not take this for granted.  I am grateful to no end to the brave doctor here is NY that did a FT via colonscopy for me.
 
I wish that there was a way that we could push for clinical trials.
 

trojen
Regular Member


Date Joined Oct 2011
Total Posts : 288
   Posted 11/1/2011 6:04 AM (GMT -6)   
Hey guys,

My 6 year old son Jack had a scope Ft last Wednesday. He is diagnosed with UC and a severe cdiff infection. He is doing amazingly well thus far. However, he did not have a bm the past two days....today will be day three. Is constipation a side effect of FT????

Also, for those looking into FT for UC (without cdiff). There are doctors in the US that are starting to do this. There are a couple in NY, but they are not openly advertising for whatever reason? That said, the Borody protocol is posted, along with others on this forum. If you know your gut flora is messed up, it is worth a try. The case studies above used at home protocol.

Levi
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Date Joined Nov 2009
Total Posts : 1597
   Posted 11/1/2011 6:59 AM (GMT -6)   
Trojen...maybe it's just an effect from being cleaned out from the scope? I know I go less after I do a prep for a colonoscopy or even sigmoidoscopy.


A lot of articles say FT could work for IBD or work for UC, but they very rarley specifically state "Crohn's" What are the data behind FT and Crohn's?

Post Edited (Levi) : 11/1/2011 1:07:26 PM (GMT-6)


trojen
Regular Member


Date Joined Oct 2011
Total Posts : 288
   Posted 11/1/2011 1:21 PM (GMT -6)   
I've noticed that as well. If the bulk of your gut flora resides in your colon, that would explain the focus on UC instead of crohns. That said, if someone has crohns and is willing to try it, I would definitely suggest doing the NG tube to ensure things flow through the small intestines as well. There is also the possibility of the immune system "resetting" with a FT, if that is the case, it could help other autoimmune diseases???

subdued
Veteran Member


Date Joined Dec 2008
Total Posts : 3231
   Posted 11/1/2011 3:13 PM (GMT -6)   
Fecal Transplant has been the best thing that has ever happened to me too. When I first started posting on this forum, I got a lot of resistance to it. I heard voodoo science, placebo effect, you'll get some kind of horrible disease from it, gross me out... But it made sense to me given my situation and it worked and worked fantastically even though I had done it on my own. I am convinced that without it, my condition would have kept getting worse until I would have needed surgery. Medicine can not cure a fecal flora imbalance. Only bacteria can.

sas
Veteran Member


Date Joined Jan 2005
Total Posts : 532
   Posted 11/1/2011 4:26 PM (GMT -6)   
there was some recent published that it helps MS.  I will try to find the article and post it.

trojen
Regular Member


Date Joined Oct 2011
Total Posts : 288
   Posted 11/2/2011 6:39 AM (GMT -6)   
Jack is doing great. Formed stools, back at school, no signs of depression or anxiety....incredible. We do need to contain our emotion a bit. The doctor said to give it a good month to ensure colonization.

I recommend FT for anyone dealing with cdiff.

I recommend FT for UC-ers if you suspect a gut flora inbalance. If you have ever responded to probiotics, your gut flora is probably involved.

The other theory (less supported) for FT with UC-ers: The FT will trigger an immune response and essentially "reset" your sytem while stopping the chronic inflammation cycle.

Thanks to subdued, jeremy, and sas, for their inspiration. If this holds for Jack, we will join forces and help spread the word.

sas
Veteran Member


Date Joined Jan 2005
Total Posts : 532
   Posted 11/2/2011 12:22 PM (GMT -6)   
http://t.co/bYe5l1GY

this is .the link for MS article and FT
Stacy

runcycle
Regular Member


Date Joined Jun 2009
Total Posts : 77
   Posted 11/2/2011 2:12 PM (GMT -6)   
Hi Trojen. You asked the question whether FT might help with other autoimmune diseases. Speaking from personal experience, FT worked for my UC, but not for my axial spondylitis (possible Anklylosing Spondylitis, but never diagnosed as such).

I have been in remission for 1.5 years from a 14-day at home FT procedure.

trojen
Regular Member


Date Joined Oct 2011
Total Posts : 288
   Posted 11/4/2011 1:48 PM (GMT -6)   
Jack had a set back. He picked up strep throat at school and had to get penicilin shot. We chose this route to hopefully be easier on his new gut flora. Either way, it totally sucks and could alter his FT success.

cg1
New Member


Date Joined Mar 2012
Total Posts : 2
   Posted 3/24/2012 8:48 AM (GMT -6)   
Trojen, what is the progress of Jack's treatment after the penicillin shot?

cg1
New Member


Date Joined Mar 2012
Total Posts : 2
   Posted 3/24/2012 9:07 AM (GMT -6)   
runcycle said...
Hi Trojen. You asked the question whether FT might help with other autoimmune diseases. Speaking from personal experience, FT worked for my UC, but not for my axial spondylitis (possible Anklylosing Spondylitis, but never diagnosed as such).

I have been in remission for 1.5 years from a 14-day at home FT procedure.


Runcycle, do you have any more information on the at home FT procedure or maybe you can point me in the right direction, there isnt much online that I am finding in regards to this and I am really interested. Thanks!

bananagirl
Veteran Member


Date Joined May 2011
Total Posts : 4486
   Posted 3/24/2012 9:23 AM (GMT -6)   
cg1, there is the dr. borody protocol. when you go to the link, click on the part where it says you can view the FT protocol.
 
 
 
 

trojen
Regular Member


Date Joined Oct 2011
Total Posts : 288
   Posted 3/24/2012 11:36 AM (GMT -6)   
cg1,

Welcome to HW. Jack is doing great...the pennicillin didn't do the trick though. He needed amoxicillin and finally azithromycin to clear his strep. Remarkebly, his FT and new gut flora held strong and he is still going strong. We are approaching 5 months of remission since starting FT.
5yr old (Jack) Diagnosed UC in Aug/Sept, 2010.
Diagnosed 8/10: Inpatient for one month.
Cdiff infection from inpatient stay.
Remicade since 10/10
Severe relapsing cdiff and uc flares until: 10/11
Bacteria (fecal) transplant 10/11: Remission?
Current maintenance: 7 wk, remicade

cjchris23
New Member


Date Joined Nov 2012
Total Posts : 1
   Posted 11/25/2012 4:16 PM (GMT -6)   
You guys should check these out:

http://www.healingwell.com/community/default.aspx?f=38&m=1612467

http://www.ncbi.nlm.nih.gov/pubmed/12811208

http://www.yoojinleend.com/fmt-fecal-microbiota-transplantation.html

http://fecalmicrobiotatransplantation.com/FMT/home.html

related:

http://www.nytimes.com/2012/06/14/health/human-microbiome-project-decodes-our-100-trillion-good-bacteria.html?pagewanted=all&_r=0

http://en.wikipedia.org/wiki/Fecal_bacteriotherapy

http://www.cdd.com.au/pdf/publications/All%20Publications/2011-reversal%20of%20inflammatory%20Bowel%20disease%20(IBD)%20with%20recurrent%20feacal%20microbiota%20Transplants%20(FMT),%20TJ%20Borody,%20M%20Torres,%20JL%20Campbell,%20SM%20Leis,%20A%20Nowak,%20American%20College%20of%20Gastroenterology%20p741.pdf


Good luck. I guess you can do it yourself if you have a healthy donor like a baby or a spouse.

DBwithUC
Veteran Member


Date Joined Feb 2011
Total Posts : 1638
   Posted 11/25/2012 5:35 PM (GMT -6)   
it will be interesting to watch for the results of the Canadian randomized trial.

this report of 3 cases (practically anecdotal, since we do not know how many people he tried with no result) is similar to the initial 6 Broady presented. It is "limited and weak" evidence, and concluded in the recent review:

Systematic review: faecal microbiota transplantation in the management of inflammatory bowel disease
Author(s): Anderson, JL (Anderson, J. L.)1; Edney, RJ (Edney, R. J.)1; Whelan, K (Whelan, K.)1
Source: ALIMENTARY PHARMACOLOGY & THERAPEUTICS Volume: 36 Issue: 6 Pages: 503-516 DOI: 10.1111/j.1365-2036.2012.05220.x Published: SEP 2012

personally I am keen to see research isolate the bacteria strains that are doing the work. using the total mass of the stool just seems so risky.
11/08: ischemic colitis and scope perf colon. 12cm colon/ileocecal resected. IV antib:sepsis.
01/10: Dx: Mod. UC pancolitis. Rx: Lialda 3x.
02/11: Major flare w/antib:sinus. Rx: 40mg Pred taper. 6mp.
07/11: Histol remiss rt/trans; worse sigmoid. Rx: Rowasa & hydrocort
---
Curr: 3-6 loose stool w/ blood, limited urgency: Lialda, 10mg Pred (dependent), sf-Rowasa, VSL DS, Vit-D/C, Omg3

Petah
Veteran Member


Date Joined Nov 2012
Total Posts : 995
   Posted 11/25/2012 9:48 PM (GMT -6)   
I have read its done in other countries. I have an appointment for a consult in Sydney, from what I've learnt I'm not a serious enough case for treatment.. Hopefully if I get any worst I will be, if not, hoping this soon becomes an option for all suffers.

Petah
Veteran Member


Date Joined Nov 2012
Total Posts : 995
   Posted 11/25/2012 9:50 PM (GMT -6)   
Keep in mind if this proves successful it will not be limited to certain Countries. It will soon become more available.

kk217
Regular Member


Date Joined Jul 2010
Total Posts : 43
   Posted 10/2/2013 9:15 PM (GMT -6)   
Can someone please tell me the name/names of the docs in NY that perform the fecal transplant? I have UC and have had a stool culture that said normal enteric flora not present.

FecalTransplantForUC
Regular Member


Date Joined Feb 2013
Total Posts : 104
   Posted 3/20/2014 12:11 PM (GMT -6)   
Try Dr. Lawrence Brandt in NYC. At one point I had an appointment with him to use fecal transplants to treat my Ulcerative Colitis, however I ended up doing this myself.
---
35 year old man diagnosed with Ulcerative Colitis in summer 1999. Avoided surgery by using fecal transplants as well as a combination of drugs and dietary supplements in the summer 2011. Still symptom-free as of June 2013 with no ongoing medications, supplements or dietary restrictions! A video interview about my story is here: bit.ly/1glU5Ou
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