Generic Mesalamine vs Lialda

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Regular Member

Date Joined Apr 2011
Total Posts : 65
   Posted 1/17/2012 1:18 PM (GMT -7)   
Can no longer afford brand name Lialda and was wondering if anyone has had any experience with replacing brand name Lialda with generic Mesalamine tablets of the same dose?

Generic Mesalamine 1.2g tablets are a third of the cost with the same active ingredient as in Lialda.

Has anyone gone this route for your drugs and had success with the product.

There is a company in Barbados named Sun Pharma that sells the 1.2g Mesalamine pills at a very good price, Lialda without insurance is just way to expensive at this time.

Or is there other stuff in Lialda that the generic mesalamine doesn't have that will make all the difference in the drug working or not, or is it really just the mesalamine and the dose?

Veteran Member

Date Joined Mar 2010
Total Posts : 1180
   Posted 1/17/2012 2:00 PM (GMT -7)   
The difference between the various drugs is the delivery system and dosage. The generics use the asacol type coating as far as I know. There is a Canadian manufactured generic asacol 400mg that is sold in Canada and I think Sun Pharma's 400mg version is also sold there. Sun Pharma is an Indian company.

I would use a Canadian pharmacy if you are American. They are more reputable but require an RX. Generic mesalamine runs 30-40 cents per 400mg tab. The generics available in the US are sulfaslazine and Colazal which are compounds that break down into mesalamine in the colon. Sulfaslazine is cheap. Generic colazal is pretty expensive. Sulfasalazine causes intolerance problems in 30% of users. I ended up on colazal but I have insurance for generics. If I had no insurance I would use the generic from Canada.

Veteran Member

Date Joined Feb 2011
Total Posts : 2529
   Posted 1/17/2012 2:27 PM (GMT -7)   
it is the coatings, or chemical bonds, or other things that tme the release to ocur in the colon and not the gut or small intestine that distinguish the name brands. In some cases the ph of the gut is used to cut a chemical bond, or disolve a coating, in one case the bacteria of the colon are used to release the drug.

But the main thing about Lialda is the sponge/matrix aspect of the delivery system that allows for 1x daily dosing. If you did nto hav ethis matrix with this coating, I would take a lower does of generic more times thorught the day. I would not take several 1.2g generic tablets all at once.
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