Generic Mesalamine vs Lialda

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JHarvey
Regular Member


Date Joined Apr 2011
Total Posts : 65
   Posted 1/17/2012 1:18 PM (GMT -6)   
Can no longer afford brand name Lialda and was wondering if anyone has had any experience with replacing brand name Lialda with generic Mesalamine tablets of the same dose?

Generic Mesalamine 1.2g tablets are a third of the cost with the same active ingredient as in Lialda.

Has anyone gone this route for your drugs and had success with the product.

There is a company in Barbados named Sun Pharma that sells the 1.2g Mesalamine pills at a very good price, Lialda without insurance is just way to expensive at this time.

Or is there other stuff in Lialda that the generic mesalamine doesn't have that will make all the difference in the drug working or not, or is it really just the mesalamine and the dose?

AZYooper
Veteran Member


Date Joined Mar 2010
Total Posts : 1180
   Posted 1/17/2012 2:00 PM (GMT -6)   
The difference between the various drugs is the delivery system and dosage. The generics use the asacol type coating as far as I know. There is a Canadian manufactured generic asacol 400mg that is sold in Canada and I think Sun Pharma's 400mg version is also sold there. Sun Pharma is an Indian company.

I would use a Canadian pharmacy if you are American. They are more reputable but require an RX. Generic mesalamine runs 30-40 cents per 400mg tab. The generics available in the US are sulfaslazine and Colazal which are compounds that break down into mesalamine in the colon. Sulfaslazine is cheap. Generic colazal is pretty expensive. Sulfasalazine causes intolerance problems in 30% of users. I ended up on colazal but I have insurance for generics. If I had no insurance I would use the generic from Canada.

DBwithUC
Veteran Member


Date Joined Feb 2011
Total Posts : 3811
   Posted 1/17/2012 2:27 PM (GMT -6)   
it is the coatings, or chemical bonds, or other things that tme the release to ocur in the colon and not the gut or small intestine that distinguish the name brands. In some cases the ph of the gut is used to cut a chemical bond, or disolve a coating, in one case the bacteria of the colon are used to release the drug.

But the main thing about Lialda is the sponge/matrix aspect of the delivery system that allows for 1x daily dosing. If you did nto hav ethis matrix with this coating, I would take a lower does of generic more times thorught the day. I would not take several 1.2g generic tablets all at once.

journey2health
Veteran Member


Date Joined Oct 2009
Total Posts : 2804
   Posted 7/24/2017 3:12 PM (GMT -6)   
Just picked up my first batch of generic Lialda. $10 for a three month supply. whoopee!

DBwithUC
Veteran Member


Date Joined Feb 2011
Total Posts : 3811
   Posted 7/24/2017 4:20 PM (GMT -6)   
i read about the generic approval. who makes it?
11/08: ischemic colitis and scope perf colon. 12cm colon/ileocecal resected. IV antib:sepsis.
01/10: Dx: Mod. UC pancolitis. Rx: Lialda 3x.
02/11: Major flare w/antib:sinus. Rx: 40mg Pred taper. 6mp.
07/11: Histol remiss rt/trans; worse sigmoid. Rx: Rowasa & hydrocort
---
Curr: 1-2 soft-formed stool, no urgency: Lialda 2x, NO PRED, probiotics, Vit-D/C

Celeriac
New Member


Date Joined May 2017
Total Posts : 18
   Posted 7/25/2017 7:29 AM (GMT -6)   
My pharmacy automatically applies a manufacturer coupon for my Lialda and I pay $10 / month. Might be something to look into/ask about (if you're in the states)

iPoop
Forum Moderator


Date Joined Aug 2012
Total Posts : 10028
   Posted 7/25/2017 7:49 AM (GMT -6)   
I would assume generic lialda is made by Zydus Pharmacueticals. These links have details that ypur pharmacy might need to order it.

This is their product page for 1,200mg mesalamine delayed release tablets (aka lialda generic):
www.zydususa.com/product-details/?id=307

This is their product page for 800mg mesalamine delayed release tablets (aka asacol hd generic). My blue cross blue shield insurance didn't count the zydus 800mg tablets as a true generic, insisted it was licensed-by-asacolhd for a significant premium (certainly the pharmacy list price was only $15 less than brandnamed lialda, for this "generic").
www.zydususa.com/product-details/?id=216

Report back if you get these! Cost and effectiveness are good for us all to know. These darn insurance copays are killers, and it'd be great if we could all get an affordable mesalamine-delayed-release tablet as a generic here!
Moderator Ulcerative Colitis
John
, 39, UC Proctosigmoiditis
Rx: Remicade @5mgs/kg/6wks; daily 75mgs 6MP, 4.8g Lialda, and 2X rowasa

😐 🚻 💩 😑 💩 😫 💩 😵 💩 💩 💩 💩

Post Edited (iPoop) : 7/25/2017 8:00:16 AM (GMT-6)


DBwithUC
Veteran Member


Date Joined Feb 2011
Total Posts : 3811
   Posted 7/25/2017 9:11 AM (GMT -6)   
as long as my co-pay card works I won't try, but this is good to know
11/08: ischemic colitis and scope perf colon. 12cm colon/ileocecal resected. IV antib:sepsis.
01/10: Dx: Mod. UC pancolitis. Rx: Lialda 3x.
02/11: Major flare w/antib:sinus. Rx: 40mg Pred taper. 6mp.
07/11: Histol remiss rt/trans; worse sigmoid. Rx: Rowasa & hydrocort
---
Curr: 1-2 soft-formed stool, no urgency: Lialda 2x, NO PRED, probiotics, Vit-D/C

Spo307
Regular Member


Date Joined Jun 2015
Total Posts : 24
   Posted 8/14/2017 6:36 AM (GMT -6)   
I have been on generic lialda for about a week and a half and now have mucus and blood and abdominal discomfort I have always used lialda for the past 14 years so now I will be calling the doctor to get a RX for Lialda

carol19
New Member


Date Joined Aug 2017
Total Posts : 1
   Posted 8/17/2017 8:43 AM (GMT -6)   
Spo307 said...
I have been on generic lialda for about a week and a half and now have mucus and blood and abdominal discomfort used lialda for the past 14 years so now I will be calling the doctor to get a RX for Lialda


I saw your post from 8/14 and I feel so much better. I am newly diagnosed with colitis and took lialda for one month. It wasworking. I got a refill but they gave me the generic and have the same symptoms you described. I just called my doctor. Thank you! ( I couldn't figure out what was going on.) Thank you again! smile smile smile smile

Jehayland
New Member


Date Joined Aug 2017
Total Posts : 1
   Posted Today 11:20 AM (GMT -6)   
They just switched me to generic. I'm going to give it some time to see how it works. I was having trouble with Asacol when I was on it a few years ago, Lialda worked much better. The coating on the generic tastes odd and gets sticky when wet (Lialda did not).

I will see how it goes but may also need to request the name brand specifically.
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