How long until Prednisone starts working?

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Baggravation
Regular Member


Date Joined Jun 2011
Total Posts : 373
   Posted 2/4/2012 2:12 AM (GMT -7)   
K so I've been on Prednisone in the fast and it seemed to work right away. I've been on it for around 4-5 days now at 40mg and I don't notice an improvement. If anything, I'm having more bowel movements and I feel constipated. Every time I run to the bathroom, I feel urge to pass a really large BM but I am never able to do so - hence the constipation. One thing I did notice is that I'm able to get to the bathroom on time. Before, I wouldn't even be able to get to the bathroom before I had a BM in my pants :( But other than that, I've noticed no improvement.

What's happening? Prednisone used to be my miracle drug!

BTW - I've been on Prednison 3 times prior within a one year and a half span.

ALSO, I'm taking Imuran at the same time I take the Prednisone. Do you think the fact that I'm taking them at the same time could have some sort of effect? Also, I tend to take my calcium and Vit D also with the Imuran and Pred as well.

ManhattanMama
Regular Member


Date Joined Jan 2012
Total Posts : 450
   Posted 2/4/2012 7:35 AM (GMT -7)   
It took me a full 2 weeks at 40mg of Prednisone before I started feeling better. I had started at 20mg and was getting worse so the doc increased the dose to 40mg. Within the past 3 days there has been a significant difference. My doc said that it may just take more time at this dosage for things to cool down. I was getting desperate last week and was thinking about Remicade but for now I am going to stick with the pred. I start to taper the dose on Monday. With my first flare 7 years ago I started at 60mg and within days I was significantly better. However the side effects of the pred were so bad (gained 20lbs in 2 weeks, moon face, hot flashes, fatigue, racing heartbeat) that we decided to go with 40mg this time. Also, the area is much more limited to the rectum this time rather than the entire colon.

Hang in there and keep in touch with your doctor about how you are feeling. You may feel a turn soon.
Diagnosed with Pancolitis in May of 2005 at age of 33
Maintenance Plan: 2 (750mg) Colazal three times a day
Vitamin C, Probiotic, Multivitamin, 400mg of Folic Acid
Treatment during Flare-Up : Cortifoam, Rowasa Enemas & Prednisone (40mg & taper)
Tried Lialda with terrible side effects in Dec 2008- went back to Colazal
Tried balsalazide disodium Nov2011-led to flare-up-back on Colazal
Mother of 2

ManhattanMama
Regular Member


Date Joined Jan 2012
Total Posts : 450
   Posted 2/4/2012 7:36 AM (GMT -7)   
Are you using any rectal drugs as well? Cortifoam and Mesalamine enemas really help!
Diagnosed with Pancolitis in May of 2005 at age of 33
Maintenance Plan: 2 (750mg) Colazal three times a day
Vitamin C, Probiotic, Multivitamin, 400mg of Folic Acid
Treatment during Flare-Up : Cortifoam, Rowasa Enemas & Prednisone (40mg & taper)
Tried Lialda with terrible side effects in Dec 2008- went back to Colazal
Tried balsalazide disodium Nov2011-led to flare-up-back on Colazal
Mother of 2

Carlie
Regular Member


Date Joined Nov 2011
Total Posts : 412
   Posted 2/4/2012 7:42 AM (GMT -7)   
Sounds like you have rectal inflammation... Enema's will help that "have to go" feeling.

cARLIE
45
50 mg zoloft
Asacol 400mg 2 tablets 4x a day
1 Canasa suppositories every morning
Prednisone 40mg daily, 30 mg taper began Thanksgiving, 20 mg 12/8, 15 mg 12/15, 10 mg 12/25- flare
Entocort 3 mg 1/9 plus 10 mg prednisone, 1/14 decreased to 5 mg pred, 1/21 2.5 mg
pred, 1/27 blood on paper, 1/31 3; 3 mg Entocort and a steroid enema nightly to control flare
Tramadol for aches and pains

Captain Ca-Ca
Regular Member


Date Joined Jan 2012
Total Posts : 147
   Posted 2/4/2012 8:26 AM (GMT -7)   
"Before, I wouldn't even be able to get to the bathroom before I had a BM in my pants."

I like this. Sign this guy up! :-)

Kidding aside, the disconnect between your feeling an urge to go and what you describe as "constipation" needs some clarification. If the stool you're passing is hard or hardish you're constipated; if its more soft yet well formed its normal, and if its liquid its diarrhetic. These are important differences to grasp in your case. Should your stool be hard and pass with difficulty, I'd guess that the at least some of this sensation is attributable to the prednisone itself. It can make your bowel feel stiff. But you claim that you're going with somewhat greater frequency which would not be consistent with "constipation" at all. Its my view that you're experiencing the typical manifestations of tenesmus, an urgent desire to evacuate the bowels but with passage of little stool. These are symptoms produced by inflammation and are likely to be a sign of progress given the incontinence you reported above. Sounds to me as though the prednisone is starting to slow down your disease. Without question, give things more time.

That's $350. You can pay with cash at the front desk or we'll accept some form of slave labor if a cash payment works a hardship for you. :-)

Baggravation
Regular Member


Date Joined Jun 2011
Total Posts : 373
   Posted 2/4/2012 3:40 PM (GMT -7)   
Ahahha! You are hilarious, Captian! Thank you everyone. As for the rectal meds, I was on steroid retention enemas which worked wonders but apparently my GI thought it was not a good idea to be on them for such a long time. I was taking Betnesol retention enemas. They made me feel like I never had UC! All other rectal meds didn't help much so my new GI started me on Prednisone.

K so some clarification on the constipation VS the urgency to go all the time.

I feel like I HAVE to go a lot of the time but I don't pass a lot. When I say constipation, I mean that I have a hard time going. I want to pass a BM but it's just not happening and then I feel all bloated and weird.
Hello. My name is Gina :)

Condition: Ulcerative Colitis
Symptoms Started: Mid-October 2010
Diagnosed: January 2011
Past Drugs: Ectocort Retention Enema, Sulphasalazine(oral), Salofalk (supp.), Pentasa (supp.), Pantoloc, Betnesol Retention Enema
Current Drugs: Prednisone, Imuran

notsosicklygirl
Forum Moderator


Date Joined Dec 2008
Total Posts : 10483
   Posted 2/4/2012 3:46 PM (GMT -7)   
I agree with Ca-Ca about the tenesmus (boo) but I think you need to be patient. When I was on pred the first time, I was better so quickly, seriously, like one day and I felt "Normal". After I had a relapse and I had to increase the dose back to 40mg, it took about 10 days on 50mg before I saw a great result. I guess you never know what to expect. I Have to wonder if the more time you're on the drug, the harder a time you have responding .I wonder if anyone who has been on pred 5x in the past still responds in a day or two? I hope that we respond quickly in the future - hopefully we can avoid prednisone regardless.
Co-moderator: Ulcerative Colitis
Diagnosed with Pancolitis, Laryngopharyngeal Reflux & Migraines. Battling Extreme Exhaustion.
Currently: Asacol (2800mg) + 6mp (25mg) + Pristiq (50mg) + prilosec (40mg) +Canasa (1g PM) + cerazette

sherbear46
Forum Moderator


Date Joined Jun 2011
Total Posts : 2705
   Posted 2/4/2012 3:50 PM (GMT -7)   
The first time I used pred I responded quickly...the second time not so much. Give it time and I would definetely be trying to get some more enemas.
Co-Moderator UC

Sheri-39 years old

Diagnosed April 2009-suffered over a year prior to diagnosis

Currently taking Lialda 2 tabs in am, Protonix 40mg every day, Allegra, Zyrtec, Probiotics, Vitamin D3, Melatonin and Rowasa enema once a week.

Currently in Remission since June 2011. I seem to flare yearly Dec/Jan time frame. Hoping this winter to be different since I'm not working.

Baggravation
Regular Member


Date Joined Jun 2011
Total Posts : 373
   Posted 2/4/2012 3:58 PM (GMT -7)   
Thanks you two! I agree about the Pred not working so well anymore. The first couple times I was on it, I noticed a HUGE difference in a day or two. Now it is taking forever! This is my 4th time going on it though; that's probably why. I'm gonna see my GI soon and I'll ask her how she feels about the enemas with the Pred.

Question: If Prednisone is systemic then why take enemas? I understand they target your rectum and the lower part of your colon but the Pred is getting there too. I jut dont wanna be taking too much at one time. Pred is pretty nasty on its own. What do you think?
Hello. My name is Gina :)

Condition: Ulcerative Colitis
Symptoms Started: Mid-October 2010
Diagnosed: January 2011
Past Drugs: Ectocort Retention Enema, Sulphasalazine(oral), Salofalk (supp.), Pentasa (supp.), Pantoloc, Betnesol Retention Enema
Current Drugs: Prednisone, Imuran

Captain Ca-Ca
Regular Member


Date Joined Jan 2012
Total Posts : 147
   Posted 2/4/2012 5:11 PM (GMT -7)   
Bagravation,

"I feel like I HAVE to go a lot of the time but I don't pass a lot. When I say constipation, I mean that I have a hard time going. I want to pass a BM but it's just not happening and then I feel all bloated and weird."

That's tenesmus, its not constipation properly so-called. You want to go but there's nothing to pass, correct? That's tenesmus all right. The bloat could be gas. Are you passing gas at all when you try to go? If so, that'll explain the bloat.

By the way, isn't this just a fabulous discussion? Here you are with a fascinating, absolutely spell-binding expert, speaking about such intimacies as gas and incontinence. Few things in life attain to this depth it seems to me. Just be sure to bring your check book next time. :-)

BelleyAche
Regular Member


Date Joined Nov 2010
Total Posts : 117
   Posted 2/4/2012 6:22 PM (GMT -7)   
Captain I like the sense of humor.... and with this disease we have to find humor where we can!

I agree you must have some rectal inflammation, I myself ended up back on oral Pred this week, and my GI told me to continue the hydrocort enemas also, but Pred works really well and really fast for me.. I wish it was something you could stay on forever. Take out the moon face, the no sleep and the osteoporosis and I love it! I will be starting 6mp in alittle over a week also so I am hoping this keeps me on the right track.

For someone who was constipated her entire life these last couple of years have taken their toll. I run I run I run... never intending to becoming a runner. :)
50/f DX with pancolitis 6/2010 not currently flaring and waiting to see what my new treatment will be since I was taken off Apriso due to acute kidney failure due to my levels not being checked by my GI. (Minimal Change) Was in remission 3 months after pred.
Currently on
Flaring as of 1/12 starting round of Pred
Levothroxine 50 mcg
Folic acid
baby aspirin

Baggravation
Regular Member


Date Joined Jun 2011
Total Posts : 373
   Posted 2/4/2012 6:47 PM (GMT -7)   
I like the sense of humour, as well! :D
@ Captain - I think the bloated feeling is the gas :( I'm seeing my GI in about a week so we shall see what she says. BUT, it's not that I don't pass anything when I go. I always pass something, it's just not a lot. And it doesn't look like stool. It's white, almost clear looking. I'm thinking it's mucus.
@ Belley - I wish we could be on Pred forever without the side effects. First time I was on it, it felt like I never ever had UC. Too bad it's not so great the 2nd time around. So do you think the running helped the constipated feeling?
Hello. My name is Gina :)

Condition: Ulcerative Colitis
Symptoms Started: Mid-October 2010
Diagnosed: January 2011
Past Drugs: Ectocort Retention Enema, Sulphasalazine(oral), Salofalk (supp.), Pentasa (supp.), Pantoloc, Betnesol Retention Enema
Current Drugs: Prednisone, Imuran

Captain Ca-Ca
Regular Member


Date Joined Jan 2012
Total Posts : 147
   Posted 2/4/2012 8:12 PM (GMT -7)   
Baggravation,

"@ Captain - I think the bloated feeling is the gas :( I'm seeing my GI in about a week so we shall see what she says. BUT, it's not that I don't pass anything when I go. I always pass something, it's just not a lot. And it doesn't look like stool. It's white, almost clear looking. I'm thinking it's mucus."

I think we've got it pinned down: Its tenesmus. The mucus would be consistent with this view also as both it and tenesmus are symptoms of inflammation. Frankly, I think you're on the mend. You're having fewer bowel movements, no blood and no incontinence. That's progress. Stay the course. Here's a link that can provide some perspective:

http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/gastroenterology/inflammatory-bowel-disease/

By the way, I have some uranium mine stock I'd reluctantly sell to someone that just absolutely begged me for it. Why we could even see the transaction as a way of my expressing concern for a fellow sufferer. I mean that's me, always the patsy. :-)

Post Edited (Captain Ca-Ca) : 2/4/2012 7:18:29 PM (GMT-7)


Baggravation
Regular Member


Date Joined Jun 2011
Total Posts : 373
   Posted 2/4/2012 8:20 PM (GMT -7)   
THANKS! So can I do anything about this tenesmus? How do I make it stop? :l
Hello. My name is Gina :)

Condition: Ulcerative Colitis
Symptoms Started: Mid-October 2010
Diagnosed: January 2011
Past Drugs: Ectocort Retention Enema, Sulphasalazine(oral), Salofalk (supp.), Pentasa (supp.), Pantoloc, Betnesol Retention Enema
Current Drugs: Prednisone, Imuran

Captain Ca-Ca
Regular Member


Date Joined Jan 2012
Total Posts : 147
   Posted 2/4/2012 8:32 PM (GMT -7)   
Baggravation,

"THANKS! So can I do anything about this tenesmus? How do I make it stop? :l"

Well, there are two things you can do, actually. One, since tenesmus is a sign of inflammation, you can treat the inflammation which is precisely what you're doing by taking the prednisone. Two, you can make a generous contribution to the Captain Ca-Ca Center On Inflammatory Bowel Disease. Now admittedly, I take a small fee for my work at the Center but .... :-)

Post Edited (Captain Ca-Ca) : 2/4/2012 7:36:03 PM (GMT-7)


Carlie
Regular Member


Date Joined Nov 2011
Total Posts : 412
   Posted 2/4/2012 8:36 PM (GMT -7)   
I use a sublingual anti spasmodic ( Prescription ) and hydrocort enema's- knocks it out in a day or two.

My dr explained the steroid thing like this, you can take oral benedryl for the itch associated with a rash, or you can rub benedryl cream on the rash, the cream works instantly.

There are far less side effects with the enema's than the oral prednisone.

Carlie
45
50 mg zoloft
Asacol 400mg 2 tablets 4x a day
1 Canasa suppositories every morning
Prednisone 40mg daily, 30 mg taper began Thanksgiving, 20 mg 12/8, 15 mg 12/15, 10 mg 12/25- flare
Entocort 3 mg 1/9 plus 10 mg prednisone, 1/14 decreased to 5 mg pred, 1/21 2.5 mg
pred, 1/27 blood on paper, 1/31 3; 3 mg Entocort and a steroid enema nightly to control flare
Tramadol for aches and pains

Baggravation
Regular Member


Date Joined Jun 2011
Total Posts : 373
   Posted 2/4/2012 9:51 PM (GMT -7)   
@ Captain - Ahahaha, you just never stop do you ahah! :D I guess I'm gonna have to wait this out. Oh how I wish there was an easier solution :(
@ Carlie - I'm going to talk to my GI about the enemas. I just recently switched my GI and my previous GI took me off the steroid enemas. I actually hate steroid enemas cause I have a hard time holding them but they make me feel better instantly.
Hello. My name is Gina :)

Condition: Ulcerative Colitis
Symptoms Started: Mid-October 2010
Diagnosed: January 2011
Past Drugs: Ectocort Retention Enema, Sulphasalazine(oral), Salofalk (supp.), Pentasa (supp.), Pantoloc, Betnesol Retention Enema
Current Drugs: Prednisone, Imuran

Captain Ca-Ca
Regular Member


Date Joined Jan 2012
Total Posts : 147
   Posted 2/5/2012 10:55 AM (GMT -7)   
Baggravation,

":D I guess I'm gonna have to wait this out. Oh how I wish there was an easier solution :("

Use the adversity you're currently experiencing to build yourself up personally. Embrace the difficult to endure and endure it for there is an end to everything. That way, should this ever happen to you again and it might, you'll know going in that you're more substantial than the disease. You're a sweetheart; I'm praying for you.

Baggravation
Regular Member


Date Joined Jun 2011
Total Posts : 373
   Posted 2/5/2012 9:20 PM (GMT -7)   
@ Captain - Thanks Captain :)
@ Unbannable - it worked for me once, here's hoping it'll work it's magic again!
Hello. My name is Gina :)

Condition: Ulcerative Colitis
Symptoms Started: Mid-October 2010
Diagnosed: January 2011
Past Drugs: Ectocort Retention Enema, Sulphasalazine(oral), Salofalk (supp.), Pentasa (supp.), Pantoloc, Betnesol Retention Enema
Current Drugs: Prednisone, Imuran
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