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notsosicklygirl
Forum Moderator


Date Joined Dec 2008
Total Posts : 10173
   Posted 3/12/2012 7:31 PM (GMT -6)   
Did anyone see this article in the news today?
 
http://abclocal.go.com/kabc/story?section=news/health/your_health&id=8578237
Co-moderator: Ulcerative Colitis
Diagnosed with Pancolitis, Laryngopharyngeal Reflux & Migraines. Battling Extreme Exhaustion.
Currently: Asacol (2800mg) + 6mp (25mg) + Pristiq (50mg) + prilosec (40mg) +Canasa (1g PM) + cerazette

stereofidelic89
Veteran Member


Date Joined Sep 2011
Total Posts : 1923
   Posted 3/12/2012 8:38 PM (GMT -6)   
I just read about this, it looks like a protein blocker that specifically blocks the production of inflammation caused by this protein. It's in phase 2 development and pushing for approval by the FDA, but the article I read mentioned mentions it is still a 'drug' and targets mostly the colon, but obviously that means it can effect the rest of the body.

I wonder what risks and side effects there are to this. Does anyone know what the process is like for approving medical drugs on the market? 5-10 year process for study/approval?

This article here mentions its a mesalamine combined with a powerful antioxidant. Why not just give us the antioxidant...?

I'm going to look up the protein: Chemokine and see how beneficial it is to us....

Post Edited (stereofidelic89) : 3/12/2012 7:44:15 PM (GMT-6)


Sibby
Veteran Member


Date Joined Apr 2010
Total Posts : 1237
   Posted 3/12/2012 9:26 PM (GMT -6)   
Less inflammation in the body would be beneficial, correct?

What is interesting with this drug is how it promotes healing.

Thank you for posting this, nssg.


This is older, but it explains more about the drug: www.medpagetoday.com/MeetingCoverage/DDW/20004

Post Edited (Sibby) : 3/12/2012 8:33:16 PM (GMT-6)


bosnianboy12
Regular Member


Date Joined Dec 2009
Total Posts : 342
   Posted 3/28/2012 2:10 PM (GMT -6)   
I'm about to enter a study for this in a hospital in Long Island. I'm flaring up so much I cannot take it anymore. Hopefully I don't get the placebo.
21 year old student at Kent State University.
Diagnosed in 2003 at the age of 13 with UC or Crohn's. Diagnosis changed to Crohn's Colitis 2/8/2011. Again changed to UC 9/8/2011
Had a few remicade infusions. saved my colon. Ineffective now.
LDN started 5/25/2011. Stopped 9/8/2011.


http://www.facebook.com/ihadzovic

DBwithUC
Veteran Member


Date Joined Feb 2011
Total Posts : 1591
   Posted 3/28/2012 2:43 PM (GMT -6)   
while I think any public eduction about UC is good, and news of new treatments in trials is very welcome, - this news article (and the several other recent MDX-1100 articles discussed here recently) also annoy me a bit.
 
 
This text is more of a press release by one of the drug's creators (and undoubtedly a partner in a start up bio tech company to develop this drug). The reporter may not even be a science reporter, and did very little other than take the information the company provided.
 
The text makes it sound like there was no other treatment, except surgury, until this drug came along. Or, that whatever other treatments exist all have horrible side effects. (Some do, some don't, some bother just some people .. etc.). No drug is free of side effects, yet not one single side effect of this new wonder drug is even mentioned by the article.
 
While targeting a different segment of the complex chemical chain that comprises the gut's immune system, this approach does not appear that novel, nor do clinical rates seen so far suggest universal success. Also, no information about any adverse events observed in the trials is even hinted at.
 
I hope it does turn out to be a wonder drug with great success and no side effects; but I sure would like to hear this from an independent science reporter, or the CCFA, or the GI association - not just from a company rep with a financial stake (likely trying to raise venture capital at this very oment).
 
I repeat what I said about MDX-1100 before, along with a link to drug info at the CCFA.org site:
 
DBwithUC said...
There are a number of new treatments for Crohn's and UC in the pipeline. Different ones focus on a different point in the long chain of chemical messages in the immune system, or the actions of chemicals on the surface of probiotics, some block inflammation, some help heal after inflammation.
 
This one is not my favored racehorse. I did not like the news story because it simplified more than you need to for public consumption (some of the info was very general, and they cited/linked the entire NICB.GOV website at the top level). They also make the potential side effects of other drugs (we know none of them are perfect) sound more horrible than they are, and completely skip over any side effects or adverse reactions this drug may have. Some of the story reads more like a drug company press release rather than a news story interviewing a medical researcher.
 
I would bet Dr. Sanborn has stock in this company, and that it may be about to raise more venture capital. I'm not saying that some of the news is not good, but only that this story was pretty shallow on information, and long on "positioning" the new drug. ... ... and this is not likely to be a pill. It is currently an IV infusion, and it looks like it will be a new (and expensive) alternative to Remicade, and very profitable for hospital infusion centers.
 
This drug development effort and a number of others is reviewed in a slideshow at the CCFA.ORG site. Dr. Sanborn helped put the slides together.
 

The info on this drug (MDX-1100) begins on slide#25 and some results are shown on slides #26 & #27.
 
While there was a benefit of the drug at the highest doses (See green bars on slide#27), at lower doses the drug was no different from the placebo. about 43% of 16 people taking the highest does got remission, and 25% of the 16 people taking the medium dose got remission. This means 11 out of 32 people (34%) getting a medium or high dose got remission. But this is compared to 10 of the 54 people taking placebo (18.5%) who also got remission for some unknown reason. One view would be that MXC-1100 is about 15.5% better than a placebo. (That modest finding sure did not come through in the corporate press release passed on by KABC.)
 
However, greater numbers of people got SOME clinical response (lower symptoms) or SOME mucosal healing without getting full remission, and maybe with more treatment they would eventually get remission. So this could still be a promising drug.
 
I just mistrust press releases a bit and always try to find a more scientific presentation. Normally I would go beyond slides prepared by one of the researchers with a financial interest, and find a peer-reviewed report. But, since these slides have been vetted by the CCFA, I think the numbers are good.
 
SO two points:
 
1) all of the other slides show other drugs in the pipeline, not just MCX-1100
 
2) the effect/benefit of MCX-1100 relative to other drug options (or to its eventual cost), or to yet to be understood side-effect levels, is still to be seen.
 
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