It looks like Tagamet and PPI blockers not good for IBD

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Old Mike
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Date Joined Jan 2007
Total Posts : 2145
   Posted 6/8/2012 6:47 AM (GMT -6)   
Hot off pubmed.Not a real good study but something to be aware of.
Tagamet H2r blocker can for some reason put you into surgery.
Besides this there are other studies that indicate PPI's make you more
prone to C.diff.  The hydrochloric acid in your stomach is one of your
first lines of defense.
Old Mike
http://www.ncbi.nlm.nih.gov/pubmed/22670722

Post Edited (Old Mike) : 6/8/2012 7:31:13 AM (GMT-6)


Conquer UC
Veteran Member


Date Joined Jan 2012
Total Posts : 1028
   Posted 6/8/2012 7:03 AM (GMT -6)   
thanks for the study Old Mike...
25 yo female Nutritionist
UC pancolitis dx April 2011 ~1 month after birth of my first child. Went into remission after a course of prednisone (hated the s/e esp psychological ones!) .
Maintenance: Pentasa 3g/d. Enemas/supps daily. Acidophilus, LGG probiotic. Non-iron Mv. Low Fodmaps, Glutenfree, ?tuna, no salmon-allergic, eggs max 6/week.
Coming out of a proctitis flare that started Jan '12.

Red_34
Forum Moderator


Date Joined Apr 2004
Total Posts : 21765
   Posted 6/8/2012 7:14 AM (GMT -6)   
I wished I could get off a PPI :( Unfortunately I also have gastritis with acid reflux or I would so be off it!
SHERRY
Moderator-Allergies/Asthma and Alzheimer's, Co-moderator-UC
Diagnosed Left sided UC in '92 - meds: 6mp, Colazal, Remicade and Bentyl*Unable to tolerate ALL mesalamines*, in '11 diagnosed with IBS, Diverticulosis, Fibromylagia..I also have Sacroiilitis, Scoliosis, Raynauds, OA, PA, Rosacea, Psoriasis, Dry Eye and allergies controlled by Zyrtec and Singular

mbailey770
New Member


Date Joined May 2012
Total Posts : 5
   Posted 6/8/2012 8:45 AM (GMT -6)   
Red_34 I was just getting ready to post about a question about GERD and UC.
I'd like your input please.

I went to hospital last night because of severe heartburn. The took a regular chest x-ray and two EKG's and said nothing looked funny.
I was given some Sucralfate and Zofran. Have to take Sucralfate one hour before each meal, and Zof every 6 hours. I also went to the Dr. two days ago for unusual heart palpitations so I'm wearing a Cardiac Event Monitor now.
So...

-Does Sucralfate flare up your UC? I noticed this morning's contents was swimming in slightly orange water, no visible blood, and none on the at all so I'm at a loss.

-I'm now feeling nausea when I eat, never had that before and all I had was small cup of plain white rice, and small cup of applesauce, does this happen to you?

-I've been getting heart palpitations since the heartburn was kicking in. Do you think they are related?

I have a GI appointment in two weeks, I just hope there is nothing seriously wrong with me.

lookforcure
Veteran Member


Date Joined Apr 2012
Total Posts : 513
   Posted 6/8/2012 9:26 AM (GMT -6)   
I have never taken H2r blockers, so for me it could not be the cause of my UC and I know at least a few people like me.
Of course, any drugs (prescription or over the counter) have side effects and none of them are safe to take every single day, a few times per day for a long time.
If somebody has GERD, gastritis or a heartburn, in my opinion, they need to at least try Activated charcoal. It is much safer and more affordable.
www.charcoalremedies.com

Red_34
Forum Moderator


Date Joined Apr 2004
Total Posts : 21765
   Posted 6/8/2012 12:08 PM (GMT -6)   
mbailey, I can't comment on the Sucralfate because I am not on this. However, I on Omperazole (Prilosec) and it hasn't bothered my Uc. I don't have heartburn but acid reflux disease. I don't get the "burn" at all. It started as a painful lump like feeling in my chest and severe stomach pain. I was very nauseous from it. The Omperazole helps with the stomach pain and the nausea.

I have had heart flutters all my life - I have a mild MVP but adding in a PPI or lack of hasn't made it any worse or better.

You can try asking your questions on our GERD forum as well. I'm sure someone there might be able to help you better.
SHERRY
Moderator-Allergies/Asthma and Alzheimer's, Co-moderator-UC
Diagnosed Left sided UC in '92 - meds: 6mp, Colazal, Remicade and Bentyl*Unable to tolerate ALL mesalamines*, in '11 diagnosed with IBS, Diverticulosis, Fibromylagia..I also have Sacroiilitis, Scoliosis, Raynauds, OA, PA, Rosacea, Psoriasis, Dry Eye and allergies controlled by Zyrtec and Singular

sherbear46
Forum Moderator


Date Joined Jun 2011
Total Posts : 2512
   Posted 6/8/2012 12:58 PM (GMT -6)   
I've been on protonix since I was pregnant with my daughter and took prilosec every day before that. I always seemed to have heartburn. I've never had an endoscopy but I'm sure my GI will hit me up for it eventually. I have tried to get off the Protonix but the heartburn comes back.

I think at this point everything we take can have a negative effect on us in some way and if I worry too much about it then I will never leave my bed in the morning. I take each day as it comes and thats all I can do. :)
Co-Moderator UC

Sheri-39 years old

Diagnosed UC/IBS April 2009-suffered over a year prior to diagnosis.

Currently taking Lialda 2 tabs in am, Protonix 40mg every day, Allegra, Zyrtec, Probiotics, Vitamin D3, Zocor and Rowasa enema once a week.

Currently in Remission since June 2011.

BabeintheWoods
Veteran Member


Date Joined Jan 2010
Total Posts : 2067
   Posted 6/8/2012 2:47 PM (GMT -6)   
Besides this there are other studies that indicate PPI's make you more prone to C.diff. The hydrochloric acid in your stomach is one of your first lines of defense

The stomach acid also keeps the H. Pylori which causes ulcers in check. I seem to be one of the lucky ones because when I have heartburn I just cut back on caffeine and chocolate for relief.
Male/60 DX ulcerative colitis Feb08, or maybe Crohn's colitis.
No Meds, allergic to Mesalamine. Remission since Mar10. Psyllium seed mixed with VSL3 is very helpful. Food journal instead of SCD.

Lots of fruit & vegetables (but no plums, kale, or carrots), no soda, no gluten, no HFCS, no xylitol or sorbitol, no trans fat, no shellfish, few processed foods, no carrageenan.
Probiotics, fish oil, multivitamin, extra D3, K2, high gamma E, phos choline, magnesium, boswellia, curcumin, glutamine.
Nature created all of the locks, therefore Nature has all of the keys

Probiotic
Veteran Member


Date Joined Mar 2007
Total Posts : 2631
   Posted 6/8/2012 4:08 PM (GMT -6)   
Of somewhat related interest, the near eradication of h.pylori in the West may be a major player in the growth in obesity in the past few decades, because h.pylori had apparently co-evolved in humans to help regulate ghrelin to suppress appetite after meals.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1773634/
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