New treatments for Colitis

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Alternatives
New Member


Date Joined Jun 2012
Total Posts : 1
   Posted 6/13/2012 9:41 AM (GMT -6)   
I have had various bouts with colitis for 33 years. Starting when i was 22 until new as i am turning 55.
There are many new treatments that most people are not educated about.

Stem cells can be used to bring the condition into remission.
I have used Adipose stem cell treatments to bring a long and painful flare up into immediate remission.
Adipose stem cells come form the fat of the patient.

Stem cells are signaling cells within the body that help to organize the body around healing an area.
Stem cells gravitate to inflammation. When stem cells are administered to a colitis patient, the stem cells go to
the site of inflammation and start sending out signals to heal the condition.

The stem cells can halt the inflammation and then allow the area to heal.

it is a remarkable and a long overdue treatment for colitis.

steroids and surgery are not the answer

Andrev
New Member


Date Joined Jun 2012
Total Posts : 18
   Posted 6/13/2012 10:19 AM (GMT -6)   
Hello Alternatives!
When did you get the stem cell treatment? Are you still in remission after it? I am participating in a study an am getting a stem cell infusion this Friday. Do you think it will help me get out from steroid dependence and take my colitis into remission?

stereofidelic89
Veteran Member


Date Joined Sep 2011
Total Posts : 1913
   Posted 6/13/2012 10:41 AM (GMT -6)   
I have actually read of this treatment, its interesting how many new treatments are coming to light for colitis.


I like this statement: "Since the intestine is one of the most rapidly renewing tissues in the body, once researchers find out what activates these cells, this could lead to new treatments that could help the colon repair itself."
From this blogger.
www.everydayhealth.com/blog/scientist-patient-looks-at-ibd-colitis/stem-cells-and-colitis/
Meds: 2400mg Asacol daily
Dietary: L-Glutamine, Omega3, Gluten-Free, VSL#3 Probiotic, Vit. D 5000iu, Boswellia caps
Amazing Herbs: Slippery Elm, Licorice & Marshmallow Root / Peppermint & Chamomile

College grad, diagnosed severe Crohns/UC - Sept. 2011
Remission achieved in february by the SCD!

pb4
Elite Member


Date Joined Feb 2004
Total Posts : 17835
   Posted 6/13/2012 11:50 AM (GMT -6)   
I thought (was hoping actually) that stem cell treatment would actually be a cure for us, not just a remission...so I take it that this stem cell procedure would have to be done repeatedly?

What all does it entail?
bee propolis caps 500mg one cap twice/day
omegas 369 caps one cap twice/day
probiotics 10 billion cfu once/day
vitamins C-calcium ascorbate (easy on the gut) and vitamin A each once/day
Prodiem fibre supplement one cap before bed
I've also altered my diet (no junky stuff at all, processed, fast-foods, refined sugars, ect) and exercise regularly.
I went from 30+ bloody BM's/day with lots of lower back pain to an average of 5/day no bleeding no back pain and completely formed stools, still have severe urgency issues.
~~~~~~~~My bum is broken....there's a big crack down the middle of it! LOL :)~~~~~~~~

Andrev
New Member


Date Joined Jun 2012
Total Posts : 18
   Posted 6/13/2012 12:01 PM (GMT -6)   
For me there will be one infusion now and another 8 weeks later and thats all..you dont have to repeat it.So i think its intended to be a cure..

pb4
Elite Member


Date Joined Feb 2004
Total Posts : 17835
   Posted 6/13/2012 12:18 PM (GMT -6)   
Where do you live? I've heard about stem cell therapy being used for another disease (just can't think of which one off the top of my head right now) in Canada, where I live....I'd be racing to see my GI if this therapy was available here.

But what all does this entail though, I'm curious of the procedure... afew years back when stem cell therapy was being discussed, it was mentioned that they have to wipe out your entire immune system (very risky as it would leave you quite vulnerable to death if they were not careful with what they were doing) and then proceed with a painful stem cell treatment.
bee propolis caps 500mg one cap twice/day
omegas 369 caps one cap twice/day
probiotics 10 billion cfu once/day
vitamins C-calcium ascorbate (easy on the gut) and vitamin A each once/day
Prodiem fibre supplement one cap before bed
I've also altered my diet (no junky stuff at all, processed, fast-foods, refined sugars, ect) and exercise regularly.
I went from 30+ bloody BM's/day with lots of lower back pain to an average of 5/day no bleeding no back pain and completely formed stools, still have severe urgency issues.
~~~~~~~~My bum is broken....there's a big crack down the middle of it! LOL :)~~~~~~~~

Dave234
Regular Member


Date Joined Oct 2011
Total Posts : 320
   Posted 6/13/2012 12:20 PM (GMT -6)   
Can you tell me more about this? I know someone who is having serious problems with this horrible affliction.

ByeByeUC
Veteran Member


Date Joined Feb 2011
Total Posts : 3058
   Posted 6/13/2012 12:23 PM (GMT -6)   
Sounds really promising. But it will only be an actual cure if works on everyone. I would be interested to see how this plays out. With UC being so strong in my family, I worry for my kids that someday they may be diagnosed with UC. Would be nice if there is a real and safe cure in the future. Still, having gone thru surgery for me is a million times better than living in the UC hell I was in.
Marianne

DX UC in 2005. Family history of UC.
Tried every drug-even Remicade-Tried diets-nothing worked-wanted my life back!
Step 1: J-pouch surgery (Laparoscopic restorative proctocolectomy w/ temporary diverting loop ileostomy) 6-25-10
Step 2: Take down surgery (Ileostomy reversal) 10/8/10
No more UC and no more drugs!! Very happy with my results of this surgery-got my life back! :)

Andrev
New Member


Date Joined Jun 2012
Total Posts : 18
   Posted 6/13/2012 12:32 PM (GMT -6)   
I am living in Hungary (Central Europe) so i have no idea about America.. My GI offered this and i said yes so i didnt actually search for it. I dont know if i can write the name of the company here but i can email it to you if you want as i heard they are doing studies around the world.

about the procedure.: its only two infusions, and lots of monitoring, blood, stool samples, colonoscopies, but nothing painful and immune system wiping. Its not like the ordinary stem cell therapy.

But as i said, im only starting it, done the initial colonoscopy, so i only know as much as the doctor told me and what was in the "contract" i had to sign.

pb4
Elite Member


Date Joined Feb 2004
Total Posts : 17835
   Posted 6/13/2012 12:39 PM (GMT -6)   
I'm Hungarian, both my parents were born there, but I was born in Canada...I figured if I was cured from this horrible disease I could finally go to visit Hungary because I sure couldn't go there with being sick like I am.

I hope this procedure comes to north america very soon, do you happen to know how long has it been available in Hungary for?

Köszönjük, hogy megosztotta velünk ezt az információt, akkor tartsa meg nekünk hogyan működnek a dolgok a postára ment el a kezelést.
bee propolis caps 500mg one cap twice/day
omegas 369 caps one cap twice/day
probiotics 10 billion cfu once/day
vitamins C-calcium ascorbate (easy on the gut) and vitamin A each once/day
Prodiem fibre supplement one cap before bed
I've also altered my diet (no junky stuff at all, processed, fast-foods, refined sugars, ect) and exercise regularly.
I went from 30+ bloody BM's/day with lots of lower back pain to an average of 5/day no bleeding no back pain and completely formed stools, still have severe urgency issues.
~~~~~~~~My bum is broken....there's a big crack down the middle of it! LOL :)~~~~~~~~

Dave234
Regular Member


Date Joined Oct 2011
Total Posts : 320
   Posted 6/13/2012 12:54 PM (GMT -6)   
I want to get this for my wife. We are living in the USA near Washington, DC. I've seen info on this but it only seems available in Mexico or Europe. If this is a cure for colitis or Crohn's, then why are they not making a HUGE deal out of this in the USA????

Andrev
New Member


Date Joined Jun 2012
Total Posts : 18
   Posted 6/13/2012 12:56 PM (GMT -6)   
Really?Then why are you using google translate?:)
But trust me, you dont wanna live here:)

I think the therapy has been available for 2 months maybe..

fruitgirl
Veteran Member


Date Joined Feb 2009
Total Posts : 6787
   Posted 6/13/2012 1:09 PM (GMT -6)   
It sounds pretty interesting, as it's not like a traditional stem cell transplant where your immune system has to be wiped out first. There's no way I'd do that over having a colectomy, because of the relatively high death risk.
Symptomatic remission as of May 2009
Colonoscopy in Oct. 2011 showed no inflammation
Symptoms began in Nov. 2008, about 4 weeks after birth of first child
Diagnosed with pancolitis in Jan. 2009
Apriso (Four 0.375 g pills once daily), Mesalamine enema twice weekly, multivitamin, vitamin D, probiotic
Used prednisone (starting dose 40 mg) to gain remission, tapered off easily

Levi
Veteran Member


Date Joined Nov 2009
Total Posts : 1537
   Posted 6/13/2012 1:17 PM (GMT -6)   
I agree, it's immensley frustrating to read about this being fairly available in Mexico, Eastern Europe, Israel, etc, but not even hearing a peep about it in America. I've watched several Youtube videos from World Stem Cells (or something close to that) of CD'ers being treated at their facility in Mexico. There is another facility in Mexico called Curismo that a Californian had great success with right before they were going to succumb to a colectomy.

I would gladly fly to any of these places and go through the treatment if I knew it had a moderatley high success rate, especially considering not only isn't it available here, it doesn't even seem to be on track to be available here at any point in the future. WTH?
Diagnosed 2009 proctosigmoiditis, 2010 Crohn's colitis, 2011 ileocolitis
Symptoms since 10.2007
Pentasa, four grams/day, 6mp 50 mg/day
Rowasa enema, 3 grams every other night
VSL#3 DS one packet/day and VSL#3 yogurt
Turmeric, digestive enzymes, boswellia, propolis, cat's claw, l-glutamine, fish oil, vitamin D, kefir, blueberries
Liver-Milk Thistle; Heart-Hawthorn, sometimes

imagardener2
Veteran Member


Date Joined Jan 2010
Total Posts : 3652
   Posted 6/13/2012 1:56 PM (GMT -6)   
I went googling because I knew nothing about this therapy. Sounds very promising and was in Phase III trials in the US as of 2008 so what's happened since then??

Here's a link to the paper dated 2008
www.ncbi.nlm.nih.gov/pmc/articles/PMC2738785/

Here are a few sentences that stood out to me (underlining is mine):

Transplant conditioning calls for an aggressive immunosuppression regimen that may play a role in inducing remission, but patients with severely impaired mucosal barrier function undergoing such a regimen may worsen their plight and face even more severe consequences. .........

Adipose tissue-derived MSCs[101] have been shown to possess promising potential for ulceration healing in perianal manifestations. .......

ProchymalTM, developed by Osiris Therapeutics Inc.[75], is a preparation for intravenous infusion of bone marrow-derived MSCs obtained from healthy adult donors. ..... One-third of the patients reported Inflammatory Bowel Disease Questionnaire (IBDQ) scores of at least 170, indicating they had achieved clinical remission of their disease. The Food and Drugs Administration recently allowed ProchymalTM to advance to a phase III double-blind placebo-controlled trial via Fast Track for the treatment of CD. After GvHD, CD is the second indication for which Osiris received Fast Track status to advance to Phase III. Osiris received orphan drug designation from the FDA and the European Medicine Agency (EMEA) for ProchymalTM. This intravenous preparation of MSCs may have peripheral immunomodulatory functions, leading to abrogation of the pathological inflammation typical of CD. MSCs may contribute to tissue regeneration by direct differentiation toward intestinal lineages[104], but they may also have trophic functions in the healing environment and their immunomodulatory ability may arrest disease protraction.

Current diet=SCD+Paleo modified (some fruit+dairy OK now)
In remission April 2010 after 10 years of UC with no remission ever
Jan 2010 began SpecCarbDiet (modified to remove dairy, fruit & juices,)
Gluten-free=bleeding stopped in 3 days, 95% remission in 5.5 months on SCD
(9)Balsalazide+(2)Citrucel, mesalamine enema as needed (1) VSL#3 nightly

Levi
Veteran Member


Date Joined Nov 2009
Total Posts : 1537
   Posted 6/13/2012 2:20 PM (GMT -6)   
Hey Ima.

Prochymal had a badly designed study and basically had to kick everybody out and restart the trial. That put them behind a LONG time. I think I read somehwere that the solution the placebo was in was eliciting a positive response (wonder if they investigated that furthur.) or something to that effect.

It was approved for Graft vs. Host disease very recently in Canada though, so Crohn's would be next.
Diagnosed 2009 proctosigmoiditis, 2010 Crohn's colitis, 2011 ileocolitis
Symptoms since 10.2007
Pentasa, four grams/day, 6mp 50 mg/day
Rowasa enema, 3 grams every other night
VSL#3 DS one packet/day and VSL#3 yogurt
Turmeric, digestive enzymes, boswellia, propolis, cat's claw, l-glutamine, fish oil, vitamin D, kefir, blueberries
Liver-Milk Thistle; Heart-Hawthorn, sometimes

pb4
Elite Member


Date Joined Feb 2004
Total Posts : 17835
   Posted 6/13/2012 2:24 PM (GMT -6)   
Andrev said...
Really?Then why are you using google translate?:)
But trust me, you dont wanna live here:)

I think the therapy has been available for 2 months maybe..
 
Because I can speak it and understand it but cannot write it at all and can only read a little of it....why is it not good to live there?  Not that I'm considering that, I just wanted to visit someday.

bee propolis caps 500mg one cap twice/day
omegas 369 caps one cap twice/day
probiotics 10 billion cfu once/day
vitamins C-calcium ascorbate (easy on the gut) and vitamin A each once/day
Prodiem fibre supplement one cap before bed
I've also altered my diet (no junky stuff at all, processed, fast-foods, refined sugars, ect) and exercise regularly.
I went from 30+ bloody BM's/day with lots of lower back pain to an average of 5/day no bleeding no back pain and completely formed stools, still have severe urgency issues.
~~~~~~~~My bum is broken....there's a big crack down the middle of it! LOL :)~~~~~~~~

Andrev
New Member


Date Joined Jun 2012
Total Posts : 18
   Posted 6/13/2012 3:26 PM (GMT -6)   
Sorry i didnt mean to offend you its just easier to understand english than google translated text:) its so bad...

Its hard to explain why its not good living here.. you only see decline in everything here. But thats really OT

pb4
Elite Member


Date Joined Feb 2004
Total Posts : 17835
   Posted 6/13/2012 3:49 PM (GMT -6)   
No worries, I wasn't offended :) Sorry to hear that about Hungary, it's such a beautiful country...hope the stem cell treatments work for you and you can be rid of this horrible disease for good!
bee propolis caps 500mg one cap twice/day
omegas 369 caps one cap twice/day
probiotics 10 billion cfu once/day
vitamins C-calcium ascorbate (easy on the gut) and vitamin A each once/day
Prodiem fibre supplement one cap before bed
I've also altered my diet (no junky stuff at all, processed, fast-foods, refined sugars, ect) and exercise regularly.
I went from 30+ bloody BM's/day with lots of lower back pain to an average of 5/day no bleeding no back pain and completely formed stools, still have severe urgency issues.
~~~~~~~~My bum is broken....there's a big crack down the middle of it! LOL :)~~~~~~~~

Andrev
New Member


Date Joined Jun 2012
Total Posts : 18
   Posted 6/13/2012 4:46 PM (GMT -6)   
Meanwhile, I've found a thread mentioning it, so i guess its okay: the stem cell therapys name is multistem and is made by Pfizer if you want to look for trials in your area.

Sibby
Veteran Member


Date Joined Apr 2010
Total Posts : 1222
   Posted 6/13/2012 5:02 PM (GMT -6)   
clinicaltrials.gov/ct2/show/NCT01240915


Here's more information regarding this trial.

DBwithUC
Veteran Member


Date Joined Feb 2011
Total Posts : 1553
   Posted 6/13/2012 5:03 PM (GMT -6)   
I think this is all on track in the US. There is one line of trials using bone marrow cells (hematopoietic stem cells) that focus on the immune system. There is another line of trials using the sub-dermal stem cells (mesenchymal stem cells) also sometimes called adipose stem cells. I know MUTISTEM is in trials. It is a bone marrow stem cell that does not have to have your immune system nuked first. I think someone posted above that some mesenchymal stem cell trial had to start over, but it is ongoing too.

I understand the key to which kind of stem cell therapy might lead to a cure will be whether the underlying problem is in the stem cell of the mucosal lining, or in the stem cells that renew the immune system.

There seem to be a bunch of clinics in Ukraine that use fetal stem cells, but I think the trials in the US are using adult stem cells.

I see a few clinics in the US that say they are offering stem cell therapies, but I am unclear about the cost or how experienced they are with UC. For example, http://www.stemcellmd.org/treatments/stem-cell-treatments/

I really think that possibly within 2-3 years there will be something safe and affordable.

pb4
Elite Member


Date Joined Feb 2004
Total Posts : 17835
   Posted 6/13/2012 5:25 PM (GMT -6)   
Thanks for the link Sibby...I have crohn's colitis, so I was a little sad to read this; Exclusion Criteria:
•Subjects with a diagnosis of indeterminate colitis, or clinical findings suggestive of Crohn's disease.

I hope they look into this for crohn's disease as well, it would be so nice to have an actual cure for all IBD.
bee propolis caps 500mg one cap twice/day
omegas 369 caps one cap twice/day
probiotics 10 billion cfu once/day
vitamins C-calcium ascorbate (easy on the gut) and vitamin A each once/day
Prodiem fibre supplement one cap before bed
I've also altered my diet (no junky stuff at all, processed, fast-foods, refined sugars, ect) and exercise regularly.
I went from 30+ bloody BM's/day with lots of lower back pain to an average of 5/day no bleeding no back pain and completely formed stools, still have severe urgency issues.
~~~~~~~~My bum is broken....there's a big crack down the middle of it! LOL :)~~~~~~~~

Sibby
Veteran Member


Date Joined Apr 2010
Total Posts : 1222
   Posted 6/13/2012 6:36 PM (GMT -6)   
pb4 said...
Thanks for the link Sibby...I have crohn's colitis, so I was a little sad to read this; Exclusion Criteria:
•Subjects with a diagnosis of indeterminate colitis, or clinical findings suggestive of Crohn's disease.

I hope they look into this for crohn's disease as well, it would be so nice to have an actual cure for all IBD.


I was disappointed that they are only looking for active IBD patients. I may be in remission but I'm trying to find a safer medication to keep me here.

cherchezlafemme
Regular Member


Date Joined Aug 2010
Total Posts : 213
   Posted 6/14/2012 12:07 AM (GMT -6)   
I'm in Austria at the moment, and definitely plan on speaking with my new GI about this.

No one's mentioned anything about side effects. Are there any to be concerned about?
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