Ok here is the theory,again.
Seems they forgot one small detail.
The MPO-Hydrogen Peroxide-Chloride System producing hypochlorous acid,(HOCL).
seems to help shut down immune system after inflammation
might have posted somewhere else,taurine/5asa
this one also important taucl/neutrophils,should shut off inflammation
intestine inflammation/tnf upregulates TAUT gene expression
possible to be low
sulfur amino acids and immune system human
peroxide deactivates taubr, so also need to quench peroxide as much as possible
taurine and bromates
important taurine inflammation patent
all about taurine may have this posted somewhere else
bromine and basement membranes
The second diagram here is the pathway. EDIT link not working, but you can search MPO-Hydrogen Peroxide-Chloride System
Now it gets real interesting.
What can block this 5ASA drugs.
Or perhaps better yet Taurine to the rescue,taurine soaks up HOCL,to form less active oxidation compounds,that are less toxic.
I have been critical of Taurine ever since the report came out in the spring on Taurine conjugated bile acids causing
a massive growth in sulfate reducing bacteria,but now perhaps a different story.
If you are a vegan you have little taurine in the diet,in is only in animal meat/dairy.
You body can make it,but suppose that path is somehow blocked.
Seems humans have little of this enzyme system,perhaps we have less than normal.
Enough for now,you get the idea.
I have stopped all supplements,except for starting taurine,will see where this goes. Hopefully do not have a massive
outbreak of sulfate reducers,but since I eat meat normally, I do not expect that to happen. The sulfate reducers were do to
eating the synthetic milk fat.
It seems that a key might be that it is not taurine itself but Taurine chloramine,which inhibits the inflammation,and
taurine does not produce the Taurine chloramine in non inflammed tissue. This I suspect is due to little to know free
hydrogen peroxide in non inflammed tissue.
Seems that MSG or perhaps other gultamate inhibits bio synthesis of taurine.
Need to look at it more.
Looks like taurine up regulates NO,whether this is good or bad for UC,not sure.
For me in the past argine which makes more NO had mad be worse,but the action of taurine
cloramine may change what takes place.
N-Chlorotaurine mechanism of action.,good info. Wow this stuff kills everything,bacteria,mycobacteria,yeast fungus,worms,virus.
Looks like you loose more by boiling meat.
Dont know if this applies to humans. He processing of food may change the taurine
absorbtion in the gut. Anyone up for raw Paleo.
Taurine content foods.
Units are different,this one says cheese quite a bit.
This one says none in cheese,the link is so big took it out.
But this on on carrrageenan,is good.
There is a chart on page 12 here,taurine in health and disease.
Oysters and clams and scallops are high,
Taurine and inflammatory disease. Very good important paper.
Also interesting that prolonged activation of neutraphils can lead to exhaustion,where they run low on taurine and cant make TauCL which is antiinflammatory.
Might need a little more bromine in the diet,based on above paper,the taurine bromo amine is a real good killer at both acid and neutral ph.
Too much bromine not real good for you,but perhaps kelp pills on occasion might be inorder,still looking into this aspect.
Looks like we intake about only 150mg/day if we are not vegan,this is pretty low.
taurine feeding study.
As far back as 1992 they knew ROS was a problem.
Actually from the induction theory,we know that hydrogen peroxide was used to induce experimental colits
in the 40's/50's.
I keep finding stuff,5asa drugs seem to also scavage peroxides. Notice they also mention bicarbonate,
2 months ago I was taking 1/4 teaspoon sodium bicarbonate for a few days,at one point all bleeding stopped,
for 3 days, I could not force out any blood, and I tried.
Not all lacto bacteria good for you.
this stuff added 4/23/15
I see there is little interest in this subject but never the less will keep at it.
This is getting curiouser and curiouser.
We make our own taurine but not all that much, get some from the diet depending on how much
meat and seafood you might eat, vegetarians get very very low levels from the diet.
Anyhow there is probably lots of this stuff in our diet today, and phosphatidyl choline or lecithin started to be
produced 1920ish. When hydrolyzed in the gut or elsewhere it turns into lysophosphatidyl choline.
Well it seems to block the TAUT, taurine transporter.
Well in UC we might need a lot of taurine to down regulate the inflammatory cascade.
Crohn's there is a defect in macrophage killing ability of ingested bacteria.
Taurine might down regulate this ability even more, but so much other stuff going on
difficult to tell if good or bad.
Will add more on the lyso, if when I find it.
Would love to know if vegetarians have less crohns and more UC.
Seems that a semi vegetarian diet can help crohns,less taurine?
Switching to paleo helps some with UC,more taurine.
SCD not sure what is going on.
Lacto-ovo might be even worse,PC from eggs.
I am not talking about rectal or colon mucus PC,or lack there of.
Characteristics of lysophosphatidylcholine in its inhibition of taurine uptake by human intestinal Caco-2 cells.
The characteristics of lysophosphatidylcholine (LPC) in its inhibition of the taurine uptake by human intestinal Caco-2 cells were investigated. By treating the cells with 200 microM of LPC, the taurine uptake was rapidly decreased by approximately 60%. This decrease was accompanied by an increase in the Km value for the uptake. A rapid uptake of LPC itself by the cells was also observed. The inhibitory activity of LPC was specific to the uptake of taurine and certain amino acids, while the uptake of glucose, glutamic acid and peptide (glycylglutamine) was not affected by LPC. The activity was dependent on the structure of a polar head and the bound fatty acid. The phosphorylcholine residue was likely to have played an important role, and surface active LPC with fatty acids of C14 or longer was highly inhibitory. These results suggest that the interaction of LPC with the taurine transporter in the intestinal cell membrane was the cause of the reduced taurine uptake
Post Edited (Old Mike) : 5/7/2015 6:16:37 AM (GMT-6)