Severe Joint Pain and Lialda

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New Member

Date Joined Jan 2013
Total Posts : 10
   Posted 1/14/2013 12:43 PM (GMT -6)   
I have been on 2 Lialda pills for several years with no problems. I was diagnosed with a severe pancolitis flare in December and was hospitalized for 8 days. Left the hospital on 60 mg Prednisone and 2 Lialda and getting worse. Dr decreased prednisone to 40mg and started 4 Lialda a day. After about 1.5 weeks, I have been getting severe pain at night in the inside of both knees, my right wrist, and right ankle which is excruciating. Dr. isn't sure if its just arthritis from the UC or if its the Lialda. Anyone have any similiar problems while taking Lialda? confused
UC Diagnosis - Aug 2001
Pancolitis Diagnosis - Dec 2012
Lialda - 4 a day
Prednisone - 35 mg a day
Prilosec - one a day

Forum Moderator

Date Joined Jan 2011
Total Posts : 1862
   Posted 1/14/2013 1:58 PM (GMT -6)   
I have been taking Lialda for a few years now and never had any problems with it.
54, female - diagnosed with ulcerated proctitis/mild colitis
Anucort AC - 25 mg; once a day
Canasa - twice a day
Lialda - twice a day
VSL#3 DS - 1/2 pack a day
Zocor - 40 mg
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Valerian - when needed for sleep
St. John's Wort, Black Cohosh, ginger

Veteran Member

Date Joined May 2010
Total Posts : 8381
   Posted 1/14/2013 2:00 PM (GMT -6)   
Tapering the prednisone might be a cause of the joint pain. The illness might be a cause of the joint pain, too, but then you'd think the pred would help relieve that. So I would guess it's the taper that's giving you problems.
50 yrs old, IBD diagnosis in spring '01. Proctitis, gastritis, ileitis.
Currently taking Pentasa (3g/day)Colazal (96 pills/day), Sulfazine (1.5 g/day), Prevacid, folic acid, vit. D (2K iu), flax seed oil (2 tsp/day), mesalamine enema as needed. Gluten free as of 5/30/11. Colonoscopy found no evidence of inflammation on 8/16/12.

Forum Moderator

Date Joined Jun 2011
Total Posts : 3315
   Posted 1/14/2013 2:11 PM (GMT -6)   
I agree with Kazbern. I am also on Lialda and have taken 4 while flaring and never had a problem. Pred though has made my body hurt like crazy.
Co-Moderator UC and Breast Cancer forums

Sheri-40 years old

Diagnosed UC/IBS April 2009-suffered over a year prior to diagnosis.
Diagnosed Chronic Uticartia January 2013-have had it for 10+ years before diagnosis

Currently taking Lialda 2 tabs in AM, Protonix 40mg, Allegra, Singulair, Xyzal, Probiotics, Vitamin D3, Hydroxyzine (as needand) Generic Rowasa enema twice a week.

New Member

Date Joined Jan 2013
Total Posts : 10
   Posted 1/14/2013 2:16 PM (GMT -6)   
I hope its not the Lialda because it seems to be helping my flare. Dr didn't think it was the prednisone taper because I had no problems tapering from 60mg to 40mg, and have only tapered down to 35mg when the pain started.
UC Diagnosis - Aug 2001
Pancolitis Diagnosis - Dec 2012
Lialda - 4 a day
Prednisone - 35 mg a day
Prilosec - one a day

Veteran Member

Date Joined Aug 2012
Total Posts : 9088
   Posted 1/14/2013 2:21 PM (GMT -6)   
I definetly don't think it is the Lialda.
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Discontinued: Robinul; Natural - peppermint oil, Inflaguard (Boswellia), Pepto Bismol, Omega 3 fish oil, Imodium, Beano, Zymactive, Renew Life Probiotic 80 billion, Florastor, Slippery Elm, DGL, Monolaurin

Regular Member

Date Joined Sep 2012
Total Posts : 20
   Posted 1/14/2013 2:37 PM (GMT -6)   
Sorry you had such a terrible flare. Even small decreases of the pred can cause severe joint pain. Usually only lasts about three days though if I understand correctly.
13 year old daughter diagnosed with severe ulcerative colitis throughout the colon on 7.2.2012
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