Natural TNF Inhibitors as an alternative/supplement to Remicade and Humira

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Canada Mark
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   Posted 2/21/2013 9:29 PM (GMT -6)   
Someone a while ago asked about other natural sources of TNF Inhibitors as an alternative to Remicade or for non-responders and such. It took me a while to find the paper but here is the cut and paste of it listing not only food types but sources to studies and so on.

I mentioned before eating six fresh red delicious apple peels a day = the same dosing/blood levels of TNF Inhibition as a typical every 8 week remicade infusion. Just well it's not very ummm practical. I'm still looking for the source of this. Will post it when I find it or well.. if I find it.

Then again $3,500+ every 8 weeks isn't all that practical either ;)


-------------------------
Other inhibitors of tumor necrosis factor action In addition to the TNF antagonists described in this review, pharmacologic agents that either suppress TNF production or block its action have also been examined. For example, the phosphodiesterase inhibitor pentoxifylline inhibits TNF transcription (Doherty et al., 1991), whereas CNI-1493, a tetravalent guanylhydrazone, inhibits TNF translation (Cohen et al., 1996).

Thalidomide has been shown to inhibit TNF action by enhancing TNF mRNA degradation (Moreira et al., 1993). After promising results with thalidomide in a number of chronic diseases, including RA, thalidomide analogues were synthesized (e.g. lenalidomide). These analogues demonstrate both anti-inflammatory and antitumor effects and inhibit TNF production (Galustian et al., 2004).

A number of natural agents derived from fruits and vegetables have also been shown to function as TNF inhibitors. These inhibitors have been the subject of review by Paul et al. (2006). Based on their chemical structure, these natural products can be broadly categorized into polyphenolic and nonphenolic compounds. The polyphenolic compounds include the flavonoids, which are found in relatively high concentration in fruits, vegetables, nuts, and grains. Examples of flavonoids that modulate TNF signaling include naringenin (in grapefruit), resveratrol (in grapes), and quercetin (in garlic and onion). The nonphenolic compounds can be further categorized into alkaloids (e.g., lycorine found in several plant species including the bush lily Clivia miniata), terpenes (e.g., acanthotic acid isolated from Acanthopanax koreanum), fatty acids and their derivatives (e.g., 13-HOA isolated from linoleic acid by corn and rice lipoxygenase), sterols (e.g., guggulsterol isolated from Commiphora mukul gum), and retinoids (e.g., retinoic acid, a vitamin A metabolite). These natural compounds generally function by reducing TNF protein synthesis, reducing TNF release or inhibiting TNF mRNA expression. Additionally, some of these compounds have been found to interfere with various proinflammatory mediators, such as nitric oxide, cyclooxygenase-II, and prostaglandin E2, and are thought to modulate TNF activity or production via these molecules.

Signal transduction pathways and transcription factors have also become targets in the management of chronic inflammatory diseases. Tas et al. (2005) published an extensive review of these pathways and described the progress to date in the development of small molecule inhibitors and gene therapy that target pathways involved in the pathogenesis of RA.

Source: http://www.dxy.cn/upload/TNFantagonist.pdf - Tumor necrosis factor antagonist mechanisms of action: A comprehensive review

notsosicklygirl
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Date Joined Dec 2008
Total Posts : 9603
   Posted 2/21/2013 9:33 PM (GMT -6)   
I've heard welbutrin is a TNF inhibitor. it's not natural but it's cheaper than biologics.
Co-moderator: Ulcerative Colitis
Diagnosed with Pancolitis, Laryngopharyngeal Reflux & Migraines. Battling Extreme Exhaustion.
Currently: 6mp (25mg) + Lialda (2400mg) + Canasa (1g PM)

Canada Mark
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Date Joined Jan 2013
Total Posts : 1711
   Posted 2/21/2013 9:38 PM (GMT -6)   
Yeah - there's a thread on here about that as well - which also ties into the whole amino-acid therapy thing.

Would be nice to hear from some others in regards to sucsess/failure on trying that. Like you say - It sure is cheaper and maybe could help those without means/insurance and all that great stuff for Remicade and Humira
Diagnosed Crohns-Colitis about 8 years ago - Past Meds: Antibiotics, Prednisone, Methotrexate, Remicade - Current Meds: Prednisone 30 mg/Daily, Immuran (Jan 21, 2012) 150 mg daily. Actually achieved full clinical remission for about 2 years using Remicade, Diet (SCD) and Exercise

“An expert is a person who has made all the mistakes which can be made, in a very narrow field.” - Niels Bohr

boumboumbambino
Regular Member


Date Joined Feb 2011
Total Posts : 133
   Posted 2/21/2013 9:50 PM (GMT -6)   
You just eat the peel of 6 apples or 6 apples..
Anyhow.. I would gladly eat 6 apples a day if that could replace remicade!!!!
27 years old female, diagnosed with ulcerative colitis in 2007
Remicade every six weeks
Diet ; no gluten , no dairy, no processed foods., curcuma, garlic, coconut oil
Supplements : homemade water kefir, digestive enzymes

Canada Mark
Veteran Member


Date Joined Jan 2013
Total Posts : 1711
   Posted 2/21/2013 10:12 PM (GMT -6)   
Yeah - Just the peal... The majority of the Polyphenols are found in the peal only. Leaving a little bit of the apple i.e. peeling it deeper into the body provides some supporting as well. It's killing me that I can't find the source of this. It's literally disapeared of the net - It was an article in Science Daily and was actually about something else - they were testing for levels of TNF Inhibitors and Antioxidants in various types of fruits and realized Red Delicious Apples (specifically the peals) contained the most compared to both other apple types and other fruits and veggies and had the biggest effect on TNF Inhibition.

Six Apple peels a day... they summed up the article by doing the math comparing to biologicals - and the author joking suggested he does not recommend people try trying to eat six apple peals a day as it seemed very impractical but had hoped they could figure out a way to isolate these specific compounds in pill form as an alternative to biologicals...

I was like you - six apple peels... really... that's not to hard... then I bought a bag and started peeling and well I made it two days! lol... It's harder than it sounds. Plus all the fiber...

As for why I can't find this anymore for the life of me - I smell conspiracy theory with big pharma ;)
Diagnosed Crohns-Colitis about 8 years ago - Past Meds: Antibiotics, Prednisone, Methotrexate, Remicade - Current Meds: Prednisone 30 mg/Daily, Immuran (Jan 21, 2012) 150 mg daily. Actually achieved full clinical remission for about 2 years using Remicade, Diet (SCD) and Exercise

“An expert is a person who has made all the mistakes which can be made, in a very narrow field.” - Niels Bohr

aguywithuc
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Date Joined Jun 2010
Total Posts : 2339
   Posted 2/22/2013 5:03 AM (GMT -6)   
Following TNF paper did nothing for me.

boumboumbambino
Regular Member


Date Joined Feb 2011
Total Posts : 133
   Posted 2/22/2013 10:23 AM (GMT -6)   
Canada Mark, LOL, yeah I can imagine eating the peel of six apples in a row would be a little too much... but eating six apples with the peel on trough the day wouldn't be that bad...
27 years old female, diagnosed with ulcerative colitis in 2007
Remicade every six weeks
Diet ; no gluten , no dairy, no processed foods., curcuma, garlic, coconut oil
Supplements : homemade water kefir, digestive enzymes

Old Mike
Veteran Member


Date Joined Jan 2007
Total Posts : 2150
   Posted 2/22/2013 11:53 AM (GMT -6)   
I have taken apple polyphenol concentrated supplement,did nothing for me.
Old Mike

bananagirl
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Date Joined May 2011
Total Posts : 4125
   Posted 2/22/2013 12:41 PM (GMT -6)   
when i was a fruitarian, i'd throw back 6-9 apples a day WITH the peels. looking back now, i had the stomach of an anaconda.
Joanna 23
Current: 3-6 bms/day. cdiff right now taking vancomycin
Supplements: vit D, kefir, CLO, astaxanthin, b12 shots, spatone iron, colostrum, enzymes, scdophilus, tart cherry, l-glut
Diet: SCD/paleo. yogurt, meat, veggies, fruit
Tried: canasa, rowasa, entocort, pred, 6mp, remi, humira, lialda, welchol, bentyl, LDN, cipro, flagyl, VSL, Vit E, 8 FT, clay, aloe, slip. elm

Post Edited (bananagirl) : 2/22/2013 3:57:28 PM (GMT-7)


Canada Mark
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Date Joined Jan 2013
Total Posts : 1711
   Posted 2/22/2013 4:16 PM (GMT -6)   
It did mention dry-freezing them or umm isolating and flash freezing in pill format or something like that... I forget the term as it discussed powdered polyphenol suppliments were lacking some supporting things that promote the TNF Inhibition that are only found when the apple is freshly peeled. It think oxidization might have had something to do with it... can't really remember. But I think that;s where the joke about peeling all those apples came into play.

Good lord I want to find this darn paper! Grrrrrrrr.
Diagnosed Crohns-Colitis about 8 years ago - Past Meds: Antibiotics, Prednisone, Methotrexate, Remicade - Current Meds: Prednisone 30 mg/Daily, Immuran (Jan 21, 2012) 150 mg daily. Actually achieved full clinical remission for about 2 years using Remicade, Diet (SCD) and Exercise

“An expert is a person who has made all the mistakes which can be made, in a very narrow field.” - Niels Bohr
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