Resistant Starch diet improves UC

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Little Buddy
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Date Joined Jun 2010
Total Posts : 52
   Posted 4/1/2013 3:00 PM (GMT -6)   
I have been following this thread with great interest and plan on getting some Navy Beans ASAP. I'm also expecting my RX for Uceris to show up today, and I'm wondering if a diet high in resistant starches will make it, or any drug (like Lialda) that is supposed to become active when it hits the colon, more effective. I say that because in the very first posting of this thread is an article called "ulcerative colitis in remission: A potential new target for dietary intervention" where they found that...

"...Whole Gut Transit Time in UC on the low WB/RS supplements showed wide variation (17 to 96 h) compared with controls (39 to 96 h). With high Wheat Bran /Resistant Starch, WGTT consistently decreased (mean 51 to 40 h; p = 0.02) in controls, while its variance in UC considerably reduced (mean 42 h, range 24 to 77 h).

So for us UC'ers with high RS consumption, food and presumably medicines could take longer to get through your system (more like a normal person). Uceris is a topical med, so the longer the contact the better...
38 YO Dx 9/2009 with left-side UC. Last scope 11/12 downgraded to proctitis
Meds: Lialda x 2 or 3 depending on how I feel
Supplements: folic acid, calcium, vitamin D, olive oil, melatonin, Align

TheAnswersYouSeek
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Date Joined Jan 2013
Total Posts : 2543
   Posted 4/1/2013 3:19 PM (GMT -6)   
interesting patent request re butyrate and budesonide (uceris).. they threw in some mesalamine too
www.google.com/patents/US20100184728

www.gastroendonews.com/ViewArticle.aspx?d=In%2Bthe%2BNews&d_id=187&i=October+2012&i_id=889&a_id=21908

killcolitis
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Date Joined Dec 2009
Total Posts : 2396
   Posted 4/1/2013 3:34 PM (GMT -6)   
A good article on fiber, paleo and butyrates if anyone's intersted:

http://chriskresser.com/myths-and-truths-about-fiber

DanthaMan
Regular Member


Date Joined May 2005
Total Posts : 495
   Posted 4/1/2013 4:32 PM (GMT -6)   
I remember someone either posting or reading on another forum about tapioca starch. I believe the guy was from India and was put into remission from it.
ACES+Zinc
Heathers Peppermint Oil
Curamed
Ubiquinol

UC since 2001, 31 year old male. Finding relief with no gluten/diary. Organic fruits/veggies/meat.

TheAnswersYouSeek
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Date Joined Jan 2013
Total Posts : 2543
   Posted 4/1/2013 6:14 PM (GMT -6)   
www.ncbi.nlm.nih.gov/pmc/articles/PMC1774255/

Short chain fatty acids, including butyrate, proprionate, and lactate, are generated in the colon as result of bacterial fermentation of dietary fibre by luminal bacteria such as Bifidobacterium, Eubacterium, and Lactobacillus species. Roediger et al demonstrated significant inhibition of butyrate but not glucose oxidation by hydrogen sulphide in the ascending colon, splenic flexure, and in the rectosigmoid region.15 A direct anti-inflammatory effect for butyrate, the most extensively studied of the short chain fatty acids, may be attributable to its inhibition of nuclear factor κB, thus preventing the transcription of proinflammatory cytokines.16 In this study, butyrate also attenuated dextran sulphate sodium (DSS) induced colitis. Furthermore, butyrate has been demonstrated to reduce colonic permeability by enhancing peroxisome proliferator activated receptor γ (PPAR-γ) activation.17 This is of special interest as PPAR-γ ligands show antineoplastic and anti-inflammatory effects in experimental colitis.18

Patients with active extensive UC have decreased colonic butyrate oxidation. As remission of disease is associated with normalisation of butyrate oxidation, UC mucosa is not intrinsically altered in butyrate oxidation.19 Butyrate enemas have been shown to be of benefit in the management of distal UC.20,21

So, how to increase faecal butyrate levels? In animal and human studies, ingestion of resistant fibre has resulted in an increase in the population of Bifidobacillus and Lactobacillus in the colon and an increase in faecal butyrate concentrations. Administration of oat bran over three months to UC patients in remission (corresponding to 20 g dietary fibre) has recently been shown to result in increased faecal butyrate levels and in this pilot study no relapses were observed.22 Alternative strategies of delivering short chain fatty acids to the inflamed colon are by providing a substrate, a “prebiotic”, for short chain fatty acid production by colonic bacteria, or directly delivering probiotics to the intestinal lumen.
Go to:
PREBIOTICS IN UC: EFFECTIVE VIA BUTYRATE INDUCTION?

Prebiotics are defined as non-digestible food ingredients that beneficially affect the host by selectively stimulating the growth or activity of bacterial species already present in the gut. A germinated barley foodstuff (GBF) which contains hemicellulose rich fibre and glutamine rich protein has been shown to attenuate inflammation in DSS, trinitrobenzene sulphonic acid (TNBS), and HLA-B27 transgenic animal models of colitis.23 In DSS colitis, GBF suppressed significantly serum interleukin 6 levels and mucosal STAT-3 expression. These effects may be caused by increased faecal butyrate production.24 GBF has been demonstrated to improve disease activity in a small pilot study in patients with active UC.25 In a controlled small study investigating 18 patients with active UC, patients were treated with baseline anti-inflammatory treatment with or without GBF. GBF therapy resulted in a significantly better outcome and was associated with increased faecal concentrations of Bifidobacterium and Eubacterium limosum.26 Another important study in the area of prebiotic and dietary fibre has been performed by a Spanish collaborative group.27 In this large study, Plantago ovata seeds (dietary fibre 20 g/day) was compared with mesalamine in the maintenance of remission in patients with UC (n = 105). Treatment failure rate was 40% in the Plantago ovata seed group, 35% in the mesalamine group, and 30% in the Plantaga ovata plus mesalamine group. A significant increase in faecal butyrate levels was observed after Plantago ovata seed administration. The same preparation was also shown to ameliorate colonic damage in HLA-B27 transgenic rats and this effect was also associated with increased production in short chain fatty acids.28 Therefore, most of prebiotic products might exert their beneficial effects via modulating short chain fatty acid metabolism.
Current: No Dairy, Sugar, Wheat or Soy.. Olive leaf (20% Oleuoropein), Lauricidin/monolaurin, NA-Cysteine, CoQ10, Psyllium/Apple pectin, Ferula, Triphalia, methylation pathway support, sodium butyrate, anantamul, Blis K12, VSL#3, PB8, Proteolytic enzymes, Proferrin

aguywithuc
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Date Joined Jun 2010
Total Posts : 3005
   Posted 4/2/2013 9:21 AM (GMT -6)   
Formyson said...
Aguywirhuc- thanks! I know everyone is different, but I am encouraged by your results. Just FYI, Edenfoods brand "properly" prepares their canned beans (soaked, then cooked with Kombu) which supposedly helps with bean digestion.

What do you mean about psyllium being tough?

Well, we have sodium butyrate on order and are going to make a big effort with this approach (among other things)


Yeah I just got some new beans last night from Whole foods that stated they soaked overnight and rinsed PLUS they tossed in the seawood which is for enzymes that breakup the sugar causing gas.

P-seed powder is just hard to consume because it is not really a food and tastes like dirt, so I either pack my own large capsules from blanks ( pain ) or buy capsules of P-seed powder but they are not as effective as the cup of beans ( NAVY ). Even if you blend into smoothies it sticks to the sides like concrete. Much happier with the Navy Beans.

3 days early I dropped another 5mg of pred yesteday to 15mg. I thought it was functioning as narcotic pain reliever because my arms ache due to the UC-related Auto accident vascular events ( clotted artery-left, clotted vein right arm courtesy of the hospital ). However I think it was just from driving errands for hours so I chilled out and took no more prednisone.

No urgency this morning with coffee and workout stims and thinking I can finally remain below 20 mg and head toward zero THANKS to RS diet. Previous drop resulted in urgency and blood, after all I am on high dose blood thinners and Nattokinase and Serrapeptase, carrying around Vitamin K2 in case I get into bloody car crash I am downing that stuff right away, taking Natto and Serra at night only when I am safely in bed and not driving to downtown Denver.

Post Edited (aguywithuc) : 4/2/2013 9:26:11 AM (GMT-6)


twiggs
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Date Joined Mar 2012
Total Posts : 795
   Posted 4/2/2013 9:39 AM (GMT -6)   
Pathogen please dont put words in my mouth. Rob Wolff who is that? I prescribe to common sense. I see by the list of things you take in your signature your on the right path or still trying to find it? None the less I was just making a point about fiber. I hope you find your remission and what works for you.
In remission!
One canasa every 3 days down from 4 asacol 800 HD a day and Canasa as needed which was often in begining. (updated 3/26/13)
Daily multivitamin,l-lysine, cod oil, adding soy protien drink and vit C esterified.
Mbiotic diet with emphasis on lots of fresh organic greens especially spinach. Fresh fruit and berries. I eat liver at least twice a month. No gluten nuts seeds.

TheAnswersYouSeek
Veteran Member


Date Joined Jan 2013
Total Posts : 2543
   Posted 4/2/2013 10:03 AM (GMT -6)   
twiggs, Im in clinical remission and am not taking any RX drugs. I obtained my remission with diet, non rx enemas, supplements and herbs.. I only put healing things into my body instead of managing symptoms. Until adding the butyrate, I experienced constipation that worried me simply because I need to move toxins. It doesnt effect my life in any way.

Rob wolf is the guy who popularized paleo.

Now Im dealing with all the things that gastros never caught, chronic infections and repairing the damage. I have not had blood, urgency, etc in 10+ months now and the recent stool test classified my colitis markers as mild to moderate (more toward mild based on the numbers, with no blood) which is pretty remarkable considering I signed myself outta the hospital AMA after being told I had no other choice but to have my colon cut out and that Id die if I left.

Im obviously alive and healthier then I can ever remember being. Sadly, I dont have any memory of being truly healthy as this disease has effected me since childhood.

Post Edited (PathogenKiller) : 4/2/2013 10:27:08 AM (GMT-6)


DanthaMan
Regular Member


Date Joined May 2005
Total Posts : 495
   Posted 4/2/2013 12:23 PM (GMT -6)   
went ahead and ordered the sodium butyrate from amazon. I did a butyrate enema about ten years ago and I can't remember what it did. That was still close to being diagnosed and I wasnt as familiar with my body as I am today. It might have helped but I was looking for a one pill cure then.
ACES+Zinc
Heathers Peppermint Oil
Curamed


UC since 2001, 32 year old male. Finding relief with no gluten/diary. Organic fruits/veggies/meat.

aguywithuc
Veteran Member


Date Joined Jun 2010
Total Posts : 3005
   Posted 4/2/2013 2:03 PM (GMT -6)   
Formyson said...
Aguywirhuc- thanks! I know everyone is different, but I am encouraged by your results. Just FYI, Edenfoods brand "properly" prepares their canned beans (soaked, then cooked with Kombu) which supposedly helps with bean digestion.

What do you mean about psyllium being tough?

Well, we have sodium butyrate on order and are going to make a big effort with this approach (among other things)


Edenfoods that is the same brand I picked up yestereday :)

aguywithuc
Veteran Member


Date Joined Jun 2010
Total Posts : 3005
   Posted 4/2/2013 2:08 PM (GMT -6)   
Little Buddy said...
I have been following this thread with great interest and plan on getting some Navy Beans ASAP. I'm also expecting my RX for Uceris to show up today, and I'm wondering if a diet high in resistant starches will make it, or any drug (like Lialda) that is supposed to become active when it hits the colon, more effective. I say that because in the very first posting of this thread is an article called "ulcerative colitis in remission: A potential new target for dietary intervention" where they found that...

"...Whole Gut Transit Time in UC on the low WB/RS supplements showed wide variation (17 to 96 h) compared with controls (39 to 96 h). With high Wheat Bran /Resistant Starch, WGTT consistently decreased (mean 51 to 40 h; p = 0.02) in controls, while its variance in UC considerably reduced (mean 42 h, range 24 to 77 h).

So for us UC'ers with high RS consumption, food and presumably medicines could take longer to get through your system (more like a normal person). Uceris is a topical med, so the longer the contact the better...


I still find that part a little confusing and interpreted it to mean WGTT reduced and the variance in range from high to low also decreased so I was expecting some speedup, but so far if anything I have had a bit of a slowdown and that beats the heck of out of urgency while at the bottom half of my final prednisone taper. Wont ever take that again it simulates a coagulation disorder in my blood and results in clots.

Formyson
Regular Member


Date Joined Nov 2012
Total Posts : 91
   Posted 4/2/2013 10:35 PM (GMT -6)   
Glad you found the Edenfoods brand, guywithuc.
We don't have Whole Foods but we do have Earthfare, and their store brand appears to be the same as edenfoods. 
 
Slowly giving my son just a small portion, to avoid discomfort, and I want to keep his sulfur levels down.

aguywithuc
Veteran Member


Date Joined Jun 2010
Total Posts : 3005
   Posted 4/3/2013 7:39 AM (GMT -6)   
Formyson said...
Glad you found the Edenfoods brand, guywithuc.We don't have Whole Foods but we do have Earthfare, and their store brand appears to be the same as edenfoods.

Slowly giving my son just a small portion, to avoid discomfort, and I want to keep his sulfur levels down.


Yeah its nice they tell you exactly how they prepared them because this is the core of my diet now. Keeping eggs and chicken but the FRAME is navy beans. After several meals of the old brand I was getting rather gassy so with Edenfoods I rinsed out the beans after opening and threw some pepperjack cheese on them as they warmed. Daughter is trying to get used to them but I had a nice plate of them, tasted fine will have to experiment and here I am 12 hours later with zero gas and high quality waste.

Taper down going fine and nattokinase + serrapeptin at night seems to work better on lower pred dose. I can thank Lima Beans for the lower pred dose no sign of bleeding at all. 15mg came early, could make a move for 10 early too. Adrenal glandulars I think do also stimulate the adrenals as well so all of this makes up my toolkit for taper to 0.00 - I found yohimbine the perfect stimulant while tapering, not only does it rev up the CNS it is not vasocontstrictive it is a vasodilator. That is key because the double strength procardia is getting good circulation into hand over remaing radial artery and I use my hands all day to drive into the city and work on computer. Now all of these things are working together to get me off prednisone and away from all doctors/surgeons.

Eating green banana's but need another RS food that is high in RS, cold potatos and cold pasta did not seem worth the trouble as they are quite low.

RS1

On the starch resistant scale of RS1 to RS4, lentils and beans come in at RS1. Using a half-cup of beans or lentils in your diet may add between 2 to 4 g of resistant starch. A daily intake of around 25 g from different sources may be adequate.

RS2

HI-Maze is example of RS food occurring naturally in granular form. This is a flour substitute.

RS3

An RS3 designation refers to foods that have been cooked and cooled such as yams and potatoes.

RS4

RS4 refers to starches that don't exist in nature and are chemically altered.

The list..

www.vitalchoice.com/shop/pc/catalog/chart-1.300.jpg

IBDISTHEPITS
Regular Member


Date Joined Dec 2009
Total Posts : 357
   Posted 4/3/2013 12:46 PM (GMT -6)   
A few questions-

Do you rinse the Navy Beans ( Eden Foods Brand) ?
Do you heat them up? Can you make a bean dip?
How much to start?

Thanks

aguywithuc
Veteran Member


Date Joined Jun 2010
Total Posts : 3005
   Posted 4/3/2013 1:12 PM (GMT -6)   
IBDISTHEPITS said...
A few questions-

Do you rinse the Navy Beans ( Eden Foods Brand) ?
Do you heat them up? Can you make a bean dip?
How much to start?

Thanks


Had my first can of Eden Foods last night, I opened the can, rinsed it good and tossed them into a heated pain, slapped some pepperjack cheese over them and chowed them down hot.

That beats potatos and pasta because

1) Hot is fine
2) Several times more RS

I think you can do anything you want with them.

zero gas since eating over half a can. You might start with 1/4 can then later in the day after other foods another 1/4 can.

I feel like I could eat the entire can with no problems now.

My newly built home has these toilets throughout I hate. They save water but I will be replacing them. When they flush its small volume but kind of violent, and normally whatever lands in there just goes into a cloud on flush, but with these beans its solid like clay and they hold their form like tree logs - like they used to.

Only thing left to do is figure out how to make their neutral flavor more tasty by adding the right stuff. So far quality swiss and pepperjack is working fine.

IamCurious
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Date Joined Jan 2010
Total Posts : 3039
   Posted 4/3/2013 2:27 PM (GMT -6)   
fyi

Eden Foods is the ONLY company that packs its canned foodstuffs without that toxic BPA. Even canned goods from Whole Foods contain BPA.
Male/61 DX IBD in Feb08. No meds, allergic to Mesalamine. Remission since Mar10. Powdered psyllium seed mixed with VSL3 is very helpful. Food journal instead of SCD or Paleo.

Lots of fruit & vegetables (but no plums or cruciferous), No Gluten, no soda, no HFCS, no xylitol or sorbitol, no trans fat, no shellfish, few processed foods, no carrageenan.
Probiotics, fish oil, multivitamin, extra D3, K2, E complex, phos choline, magnesium, boswellia, curcumin, DGL, glutamine.
Nature created all of the locks, therefore Nature has all of the keys

IBDISTHEPITS
Regular Member


Date Joined Dec 2009
Total Posts : 357
   Posted 4/3/2013 2:30 PM (GMT -6)   
Just made a dip pureeing beans and adding salt, lemon juice and some olive oil.
It is really good and easy to eat-

Do you think you need to eat RS every day to benefit from it?

also- it needs to be eaten at room temp?

Thanks
Daughter, age 12. Diagnosed with UC 10/2009 (Pancolitis)
Unable to take mesalamines.(Made her symptoms worse)
6-MP
VSL#3


Husband- Diagnosed 09/11 with proctitis-
Asacol 3 @ 2 times a day

Formyson
Regular Member


Date Joined Nov 2012
Total Posts : 91
   Posted 4/3/2013 3:22 PM (GMT -6)   
Great, IBDISTHEPITS!
I tossed a small amount into a veg broth based soup with some other easy to digest (for him) vegs.
I also made some white basmati rice (he cannot tolerate brown yet - says he feels the prickles/scrathches all throughout his colon). I cooked the rice in a little ghee (extra butyric acid boost I suppose) then served with a few navy beans added in with a little diced avocado and fresh squeezed lemon. He liked that!
I am not sure how we will tolerate this so am taking it slowly as aguywithuc explained. I think the beans are ok not at room temp if I am not mistaken. The potatoes are best cold, as the resistant starch in potatoes needs to be chilled to crystallize, I believe. As for rice, I need to check on that or maybe someone else knows... Seems like these things work right within the diet you are already doing!

Guywithuc - so glad it is going so well for you. You must be very encouraged.

Babinthewoods - Thanks for the BPA tip!! I didn't catch that about the store brand, as I was so glad to see they used the kombu, thanks! Back to Edenfoods or just soaking/cooking my own.

aguywithuc
Veteran Member


Date Joined Jun 2010
Total Posts : 3005
   Posted 4/3/2013 6:25 PM (GMT -6)   
Formyson said...
Great, IBDISTHEPITS!
I think the beans are ok not at room temp if I am not mistaken. The potatoes are best cold, as the resistant starch in potatoes needs to be chilled to crystallize, I believe.


Yes thanks all for the tips and recipes.

I eat them everyday to heal the colon as I taper pred. I can see the difference between the bean waste and the sugary yogurt waste. That's an in intra-day difference so skipping days would definitely matter. Going off the candy yogurt when it runs out tomorrow. Lowest I will go is chobani vanilla with cinnamon, plain yogurt seems unnecessary. That said RS changes the gut microbacteria or flora, therefore over time flora change plus mucosal healing would suggest later we can eat less RS as maintenance. ( more below ).

Beans are type 1, which does not change RS levels with heat so I prefer them.

The rest seem to be type 3 which does have that requirement plus they are not as high up in RS percentage, but you cant eat just beans so its good there are other choices.

RS3

An RS3 designation refers to foods that have to be cooked and cooled such as yams and potatoes.

Research on gut flora changes...

Resistant starches (RS) are starches or products of starch degradation that escape digestion and are not absorbed in the small intestine of healthy individuals . RS are classified into four categories according to the features that render it undigestible. RS type 1 is physically inaccessible starch whereas RS type 2 (RS2) is native granular starch consisting of ungelatinized granules. RS type 3 is retrograded amylose, and finally, RS type 4 (RS4) is chemically modified to achieve undigestibility. Several studies have shown RS have the potential to improve health, with one of the primary benefits being maintenance of healthy blood sugar levels . Though resistant to digestion in the small intestine, bacterial species that reside in the colon are capable of utilizing RS as a substrate. These fermentations lead to an increase of short chain fatty acids (SCFA), especially butyrate, and a reduction of secondary bile acids, phenol, and ammonia . These metabolic effects are likely to underlie some of the documented health benefits of RS, which include the prevention of colon cancer development and colitis in animal models.

Several studies have been performed to characterize the potential of RS to induce alterations in the composition of the gut microbiota.

The goal of the present study was to obtain a community wide perspective of the impact of RS on the composition of the human gut microbiota. We were further interested to compare RS4 and RS2 in this respect because most emphasis in the literature has been placed on the latter substrate.

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0015046


.

Post Edited (aguywithuc) : 4/3/2013 6:39:01 PM (GMT-6)


Formyson
Regular Member


Date Joined Nov 2012
Total Posts : 91
   Posted 4/3/2013 6:31 PM (GMT -6)   
Thanks for the type explanation. Now I get it.

aguywithuc
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Date Joined Jun 2010
Total Posts : 3005
   Posted 4/3/2013 6:46 PM (GMT -6)   
Formyson said...
Thanks for the type explanation. Now I get it.


Your welcome. After lots of snake oil, I am really happy to find something effective, available and cheap.

I value freedom and health. It is spring time again and I am almost clear of some frightening health problems when things snowballed from an anemic flare and auto accident + prednsone back in January. I am biking, weightlifting, feeling as well as thinking like a 20-year old again.

Time to navigate out of this crazy UC storm once and for all.

I guess the list goes something like this :

RS ( Navy beans topping my list )
Psylliam Seed Powder
Spinach
Salmon
prednisone

Formyson
Regular Member


Date Joined Nov 2012
Total Posts : 91
   Posted 4/4/2013 11:09 AM (GMT -6)   
That is great, aguy! What a relief for you!
Think we are seeing some improvement in frequency and consistency...don't know what that means - too early to tell (and we've been there before...). But I see the merit in this, as well as other dietary things so will keep on. We added zinc-carnosine and butyrate this week, too. My son is currently med free but only because he can't take mesalamine and has developed Remicade antibodies. I am happy he is doing this well on no meds.

aguywithuc
Veteran Member


Date Joined Jun 2010
Total Posts : 3005
   Posted 4/4/2013 11:57 AM (GMT -6)   
Formyson said...
That is great, aguy! What a relief for you!
Think we are seeing some improvement in frequency and consistency...don't know what that means - too early to tell (and we've been there before...). But I see the merit in this, as well as other dietary things so will keep on. We added zinc-carnosine and butyrate this week, too. My son is currently med free but only because he can't take mesalamine and has developed Remicade antibodies. I am happy he is doing this well on no meds.


Good, go for the Eden brand it is best.

butyrate sounded great, I bought the wrong kind, going to be trying to add that post taper to zero.

Best luck to you.

GutsZilla
Regular Member


Date Joined Dec 2012
Total Posts : 64
   Posted 4/4/2013 8:46 PM (GMT -6)   
Where do you get your zinc carnosine?? Mine is really expensive,mane I'm always on the lookout for other sources.

Formyson
Regular Member


Date Joined Nov 2012
Total Posts : 91
   Posted 4/4/2013 8:52 PM (GMT -6)   
I got the wrong butyrate too and thanks to Pathogenkiller just ordered the sodium-butyrate instead.

GutsZilla - I got a great deal on the zinc-carnosine ordering from Vitacost. Doctor's Best PepZin GI - $18.00 for 120 capsules (retail value $34).
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