Radical Induction Theory-Time to re-visit

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freddyj
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Date Joined Aug 2011
Total Posts : 1279
   Posted 7/16/2017 12:26 PM (GMT -6)   
Mike,

Read the paper but not this whole thread.. where are you on glutathione supplementation? Is iv necessary? Oral no good? And I saw in the paper there were two things that naturally neutralize H202, but dont recall them at the moment. Has this paper brought any new supplement or prescription suggestions?

Old Mike
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Date Joined Jan 2007
Total Posts : 3740
   Posted 7/16/2017 1:22 PM (GMT -6)   
Freddy: You can build glutathione with NAC and glycine, IV dont believe necessary.
I can imagine if you take glutathione orally it will break down into its base amino acids which
may rebuild it through the body.
Catalase, GPX, for peroxide.
Nothing new I can see, but it might take both oral and rectal to fix the mess.
Old Mike
UC-1980, same flare since 1986. Still smoke. MEDS: None
SELENIUM for GPx, Zinc,NAC, glycine up to 10 grams a day, for Glutathione. Folate,B12.
SOD makes me worse. Why. Makes too much hydrogen peroxide from superoxide,
then not enough GPx and catalase to convert to water,then makes hydroxyl radical.
Curcumin-Thins my blood too much.

freddyj
Veteran Member


Date Joined Aug 2011
Total Posts : 1279
   Posted 7/16/2017 2:18 PM (GMT -6)   
Thanks Mike. Wondering if this is over 10 years old why no ones delved here before? Interestingly the author relates this to stress which I had daily doses of in my youth at home- which in turn led to more in adult life.. quite profound and I have always believed its the cause of my situation.

Old Mike
Veteran Member


Date Joined Jan 2007
Total Posts : 3740
   Posted 7/16/2017 2:34 PM (GMT -6)   
A few like myself have tried orally, did not do much.
However I am now replete pretty much with selenium it takes months.
My stools are more like stools.
I have ordered more lipoic acid, will see where it goes.
OM
UC-1980, same flare since 1986. Still smoke. MEDS: None
SELENIUM for GPx, Zinc,NAC, glycine up to 10 grams a day, for Glutathione. Folate,B12.
SOD makes me worse. Why. Makes too much hydrogen peroxide from superoxide,
then not enough GPx and catalase to convert to water,then makes hydroxyl radical.
Curcumin-Thins my blood too much.

freddyj
Veteran Member


Date Joined Aug 2011
Total Posts : 1279
   Posted 7/16/2017 9:20 PM (GMT -6)   
Are you convincing me to go buy another supplement? Selenium? No interest on your part for NAC? Oh looks like you take.. Guess I need to get on the selenium and NAC train? :/ Probably will giver a try. Do you have a Selenium dose you think is working? thanks!

Old Mike
Veteran Member


Date Joined Jan 2007
Total Posts : 3740
   Posted 7/17/2017 6:31 AM (GMT -6)   
Selenium yeast 200 micrograms selenium.
After say 2 months you could back down to 100 micrograms if you want to.
I started April 19.
OM
UC-1980, same flare since 1986. Still smoke. MEDS: None
SELENIUM for GPx, Zinc,NAC, glycine up to 10 grams a day, for Glutathione. Folate,B12.
SOD makes me worse. Why. Makes too much hydrogen peroxide from superoxide,
then not enough GPx and catalase to convert to water,then makes hydroxyl radical.
Curcumin-Thins my blood too much.

Old Mike
Veteran Member


Date Joined Jan 2007
Total Posts : 3740
   Posted 7/17/2017 10:13 AM (GMT -6)   
You all might remember the vitamin E enema posts from the past.
Well here is a small clinical trial from 08. Looks like they used 15 ml of Now Natural E Liquid item # 0912.
old mike

/www.ncbi.nlm.nih.gov/pubmed/18932276

this stuff
/www.nowfoods.com/supplements/vitamin-e-54600-iu-liquid

they have on amazon and I guess other places.
UC-1980, same flare since 1986. Still smoke. MEDS: None
SELENIUM for GPx, Zinc,NAC, glycine up to 10 grams a day, for Glutathione. Folate,B12.
SOD makes me worse. Why. Makes too much hydrogen peroxide from superoxide,
then not enough GPx and catalase to convert to water,then makes hydroxyl radical.
Curcumin-Thins my blood too much.

freddyj
Veteran Member


Date Joined Aug 2011
Total Posts : 1279
   Posted 7/17/2017 12:44 PM (GMT -6)   
Thanks Mike.

Ive never had much luck with vit e enemas... got to say I don't enjoy them so theres an impatience element I suppose. Even tried cannabis oil, but just for the lack of enjoyment factor it better pay off fast or I lose motivation quick.

So Mike, are you saying the selenium is helping you significantly, even after all these years? Because you're one of the few who's been flaring longer than I.

Old Mike
Veteran Member


Date Joined Jan 2007
Total Posts : 3740
   Posted 7/17/2017 1:15 PM (GMT -6)   
Yea it has made a change, stools more solid less thin, still have blood in am though.
Blood is prior to stools.
The more I look into oxidation and UC, from these small clinical trials and pravda's work,
where remission is achieved at a high rate, I start to believe this is fixable.

I am starting to get more and more cynical.
Billions spent on biologics.

OM
UC-1980, same flare since 1986. Still smoke. MEDS: None
SELENIUM for GPx, Zinc,NAC, glycine up to 10 grams a day, for Glutathione. Folate,B12.
SOD makes me worse. Why. Makes too much hydrogen peroxide from superoxide,
then not enough GPx and catalase to convert to water,then makes hydroxyl radical.
Curcumin-Thins my blood too much.

MarjieKay
Regular Member


Date Joined Jun 2017
Total Posts : 218
   Posted 7/17/2017 2:23 PM (GMT -6)   
Old Mike said...


I am starting to get more and more cynical.
Billions spent on biologics.

OM


You mean like cynical in 'illness as a business'?

freddyj
Veteran Member


Date Joined Aug 2011
Total Posts : 1279
   Posted 7/17/2017 2:49 PM (GMT -6)   
Big pharma must be terrified of cannabis- truly truly unbelievable that people like sessions can be given legitimacy in this day and age, does not bode well for the collective wisdom of human beings. Interesting times.

freddyj
Veteran Member


Date Joined Aug 2011
Total Posts : 1279
   Posted 7/17/2017 2:53 PM (GMT -6)   
Mike would you also say NAC and catalase are making a dent? Worth doing? Its interesting what webmd says about NAC.

Old Mike
Veteran Member


Date Joined Jan 2007
Total Posts : 3740
   Posted 7/17/2017 4:24 PM (GMT -6)   
What I mean is that possibly there are solutions, other than big buck biologicals.
Perhaps most research poured in where the money is at.
Not against big pharma, my daughter works for big pharma.
Big pharma has many good drugs, and has saved many lives.

Also way too many clinical trials, with unpublished results, what is that about.
Way too much govt funded research papers, are pay per view, what is that about.
If I have to think about the answer, I again get cynical.

Anyway what I call the internet brain, may one day solve the problem.

Freddy: Not a miracle or anything just somewhat better.
Dont worry if I ever go into remission, you all will know.


Old Mike

Post Edited (Old Mike) : 7/17/2017 5:03:05 PM (GMT-6)


MarjieKay
Regular Member


Date Joined Jun 2017
Total Posts : 218
   Posted 7/17/2017 4:38 PM (GMT -6)   
Thanks for elaborating on that, OM. I agree completely. The internet brain is my hope, too.
F, 51
2008 Diagnosed with colitis
2017 Diagnosed with Chronic Ulcerative Colitis

Currently taking Pentasa, Rowasa
Advanced gut health probiotics, Primadophilis Reuteri, Benefiber, Digestive Enzymes
IBD-AID diet , no sugar & processed free, mostly grain free

Extras:
Spirulina, kelp, ginger, glutamine, vitamin C , vitamin D, zinc, milk thistle, collagen,
fish oil

freddyj
Veteran Member


Date Joined Aug 2011
Total Posts : 1279
   Posted 7/18/2017 5:50 PM (GMT -6)   
Mike, forgive me for not finding it in the paper, have been re-reading but thought you might know, or the question would be helpful to others..

I recall that the author indicated that this H2O2 could be a problem in susceptible individuals, but can't recall if this was purely defined as a genetic reference or not.

My question-

a) do you worry about selenium toxicity (I read that it can be an issue) and more to the point,

b) would we, as "susceptible' individuals, show *low* levels of selenium, Gpx, or catalase in blood tests?

I don't recall ever having tested for that, but if don't specifically ask for it, they won't necessarily check for it.

Old Mike
Veteran Member


Date Joined Jan 2007
Total Posts : 3740
   Posted 7/18/2017 6:05 PM (GMT -6)   
Not only genetic,stress,bacteria infection,other reasons,for peroxides.
Believe there is a genetic reason for low GPx.

At 200 micrograms selenium toxicity should not be a problem, as far as I know.
You could get by with 100 micrograms depending on diet.

That being said people have died from selenium supplements years ago when the supplement
for some reason had way more selenium than stated.

Also someone got very sick or died after being covered with selenium blue shampoo for a skin
disease.

Levels are lower in uc than normals, especially with extensive proximal disease.
May have something to do with absorption. Crohn's lower yet.

gpx and catalase are usually low.
OM

Post Edited (Old Mike) : 7/18/2017 6:08:58 PM (GMT-6)


freddyj
Veteran Member


Date Joined Aug 2011
Total Posts : 1279
   Posted 7/18/2017 6:07 PM (GMT -6)   
Thanks. So sounds like supplementation with all three is in order. Assuming Pravda is on to something, which since his paper is 12 years old, I guess he may not be.

Old Mike
Veteran Member


Date Joined Jan 2007
Total Posts : 3740
   Posted 7/21/2017 11:44 AM (GMT -6)   
Well crap, just got a new bottle of ALA.
This 2016 says ALA and NAC together are bad news.

ALA oral is a was used in Pravdas clinical trial,so still might be good.
Just not together with NAC.
Old Mike


/www.hindawi.com/journals/omcl/2016/4047362/

Post Edited (Old Mike) : 7/21/2017 12:15:50 PM (GMT-6)

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