Trying new drug Imuran? What to expect?

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Regular Member

Date Joined Aug 2015
Total Posts : 22
   Posted 8/20/2015 1:26 AM (GMT -6)   
Been having 6-10bms per day taking mezavent so my specialist has put me on imuran with a combination of prednisone to help with mucosal healing to get into remission. what are your experiences with Imuran? Does it work for you guys? How often does it not work and how common are the side effects

Regular Member

Date Joined Jan 2015
Total Posts : 426
   Posted 8/20/2015 1:50 AM (GMT -6)   
Did you search? There are lots of past threads identical to this one
M, 36. Pancolitis dx 2013. Asacol 4.8g, Azathioprine 100mg, Remicade (4) 320mg. Slowly improving

Regular Member

Date Joined Aug 2015
Total Posts : 22
   Posted 8/20/2015 2:32 AM (GMT -6)   
Yeah I searched I didn't see anything, I apologise if I'm reposting i am a bit incoherent right now from the pred
2 mezavant in the morning, 2 at night (4.8grams a day)
2 salofalk enemas a day
Started a course of prednisone 40mg for mucosal healing
Imuran 50mg
1 Ferro-grad c a day for anaemia
1 osteo-acute anti inflammatory (alternative therapy)
1 natures way multivitamin, 3 teaspoons Manuka honey (anti inflammatory)
17 Years old, diagnosed April 10th 2015
Before medication:20-40bms
After meds:4-10bms

Forum Moderator

Date Joined Aug 2012
Total Posts : 10565
   Posted 8/20/2015 5:10 AM (GMT -6)   
Imuran/6mp/aza are used by many of us here. When first starting it, it is know to cause nausea. Take it just before bed with some good to help avoid it.
Moderator ulcerative colitis
John, 37, uc proctosigmoiditis in remission
Rx: Remicade 5mg/kg/8 weeks and 6MP 50mgs/day
Diet: Diet mods and supplements haven't done a thing for me
Only taxes and prednisone side effects are a certainty in life.

Veteran Member

Date Joined May 2015
Total Posts : 2233
   Posted 8/20/2015 5:39 AM (GMT -6)   
In the beginning you can get nausea or headaches. I take it with a big meal ( breakfast usually) and that helps
Either way those side effects tend to go away after being on imuran for several weeks
I am going to warn you that you will not see improvement overnight in fact, it can take a couple months for the drug to reach a therapeutic level in your body.however, after several weeks you may see some small improvements.
Hopefully, by the time you are off the steroids it should've kicked in.

Good luck!
20 year old female
Diagnosed with severe uc on 4/27/15
Remicade 10 mg/kg
Imuran 50 mg
Multivitamin, biotin, calcium, and vitamin d

Regular Member

Date Joined Jun 2014
Total Posts : 302
   Posted 8/20/2015 5:56 AM (GMT -6)   
Hi Mike

I have been in azathioprine for coming up 15yrs. In that time I've never been in remission. But that's not a negative, I had a very manageable disease thanks to the drug. That said I am quite tolerant of the disease ... I have no choice I feel.

Azathioprine helps to balance out the disease - helps reduce the big crashes. Over the years I've had a few bigger flares and have largely managed without resorting to pred. That was until a couple of years ago when it all went to pot ... And azathioprine was no longer sufficient and I got stuck on steroids... With surgery looming.

Everyone will tell you everyone is different - and they are. I got a good number of years out of azathioprine alone. But don't expect miracles. Good luck.
Diagnosed: January 2000
Drugs: currently Azathioprine 150mg (Imuran) [14yrs], Humira, B12, Rivaroxaban, vitamin D3.
Previous drugs: been through the sweet shop
Bonus probs thanks to Crohns: osteoporosis and blood clots
Age: 49 (but feel over 80 when ill)

Veteran Member

Date Joined Aug 2011
Total Posts : 2997
   Posted 8/20/2015 6:46 AM (GMT -6)   
I've been on Imuran since 2005 and I've been doing good so far. Nausea off and on but that's a lot better than bloody diarrhea.
UC since 2002
Past treatments: Steroids, 5-ASAs, immunosuppressants, biologicals
Currently on 100 mg Azathioprine (Imuran), CCherbal, VSL#3, Boniva, Wellbutrin 300 mg
Scope on 3/6/2014 showed no inflammation but scarring
Also suffer from: Depression, Trichotillomania, Osteoporosis, Floaters

Regular Member

Date Joined Feb 2015
Total Posts : 435
   Posted 8/20/2015 9:35 AM (GMT -6)   
I've been on Aza for 4 months now and am still having bloody BM's a couple times a day (5-8). I can't seem to get past 10mg of pred either so for me it hasn't really seemed to work. It seems like it may have improved it a little bit since when I was on high doses of pred I was doing a lot worse and only after 2-3 months of Aza did it go from 15 to about 5-10 BMs a day but Aza alone isn't doing it. So as mentioned before, it seems to help but isn't a standalone med for me.

Sick Puppy
Regular Member

Date Joined Feb 2015
Total Posts : 32
   Posted 8/22/2015 1:57 AM (GMT -6)   
I'm staring my third month on 6MP, I was on 50 mg for one month then 100 mg after that. It does take some time to kick in, but I'm finding it helpful - I've been steroid free for almost 2 weeks now and am 90% back to normal.

I started by taking it at night as recommended here, and didn't have any side effects at 50 mg. once the 100 mg kicked in (after about a month at that dosage) I did get some nausea and a lot of fatigue...though I'm not sure if it was the 6MP, the really bad migraine, or the trip I took all around the same time :(

I've also noticed they it tends to suppress my appetite, which is actually a relief after having been on steroids for so long and wanting to eat constantly, lol
35 year old female. Diagnosed with severe UC/pancolitis November 2014.
Current meds: Mercaptopurine 100 mg

Hooray! No more steroids for now. Have tried: Prednisone/Entocort (both evil), Uceris (??), Asacol/Colazal/Balsalazide (caused stomach pain)

Veteran Member

Date Joined Jul 2015
Total Posts : 595
   Posted 8/22/2015 10:13 AM (GMT -6)   
I started Imuran (50 mg) about 3-4 weeks ago, and except for a little fatigue the first few days I've had no negative side effects - so far. I take mine in the morning with breakfast. I don't know if it's working or going to work because I am also on an increased dose of remicade. All I know is I'm not flaring right now.
Diagnosed with ulcerative colitis in 2005 and rheumatoid arthritis in 1998. On Remicade since 2005 for both diseases. For UC tried sulfasalazine, Lialda, colazal and others which made me ill. Started 50 mg. Imuran July 2015. Use Bentyl, peppermint oil capsules and Gas-X which all help with various UC symptoms during a flare. VSL3 didn't work for me.
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