Neurotoxicity with Glutamine supplementation

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

xy123
Veteran Member


Date Joined Feb 2014
Total Posts : 644
   Posted 9/30/2017 8:08 AM (GMT -6)   
Many of us know that L-glutamine has been used as an additional tool to treat IBD. (Just google "glutamine crohn's colitis pubmed" to see some of the papers)

Although This new Cochrane review says:
review said...
Currently there is insufficient evidence to allow firm conclusions regarding the efficacy and safety of glutamine for induction of remission in Crohn's disease. Data from two small studies suggest that glutamine supplementation may not be beneficial in active Crohn's disease but these results need to be interpreted with caution as they are based on small numbers of patients. This review highlights the need for adequately powered randomised controlled trials to investigate the efficacy and safety of glutamine for induction of remission in Crohn's disease.


Anyways...

I bought l-glutamine supplements to try it out; but then I've found some links between glutamine and neurotoxicity:

onlinelibrary.wiley.com/doi/10.1002/hep.21357/pdf
forums.phoenixrising.me/index.php?threads/glutamine-is-harmful-relationship-with-ammonia-and-astrocytes.38680/
/www.ncbi.nlm.nih.gov/pmc/articles/PMC4714775/
/www.ncbi.nlm.nih.gov/pubmed/11754523

/www.ncbi.nlm.nih.gov/pubmed/2566647

What do you guys think?

OM, do you think it is safe to supplement with L-Glutamine?
The dosage used to treat IBD is generally higher (around 30 grams/day) than the doses used for the purpose of physical training and muscle gaining etc...

Thanks.

Edit: This is the new Cochrane review: onlinelibrary.wiley.com/wol1/doi/10.1002/14651858.CD007348.pub2/abstract

Post Edited (xy123) : 9/30/2017 8:17:13 AM (GMT-6)


IamCurious
Veteran Member


Date Joined Jan 2010
Total Posts : 3032
   Posted 9/30/2017 2:13 PM (GMT -6)   
I have heard from more than one source that taken with food glutamine is great for bodybuilders because it helps to build muscle. But taken on an empty stomach glutamine helps repair intestinal tissue.

According to Dr. Robert Atkins, the Atkins diet guru, not only is glutamine effective for healing the digestive tract, (which is what IBDers like us need), but that it also snuffs out cravings for sugar.

On page 168 in his book, 'Dr. Atkins' Vita-Nutrient Solution', he talks how glutamine "maintains the structural integrity of the intestines to such an extent that it is dubbed 'intestinal permeability factor.' No other nutrient is as important for gastrointestinal integrity."

But I stopped taking it after more recent studies such as what you listed above show that daily glutamine intake can be problematic. But after my most recent flare I found that taking some glutamine seemed to speed up recovery. That is why my signature says I take glutamine only when I feel gut repair is needed after a flare, not regularly at all.
Male, born 1951, DX IBD Feb08. No meds, allergic to Mesalamine. Food diary instead of SCD or Paleo.
When needed VSL#3DS sprinkled over powdered psyllium seed is very helpful.

Lactobacillus Reuteri (NCIMB 30242), Culturelle, Saccharomyces boulardii.
Fish oil, curcumin, extra D3, magnesium, multivitamin, glutamine when gut repair needed.

Resistant Starch and lots of fruit & vegetables (but no cruciferous), No Gluten, no soda, no HFCS, no xylitol or sorbitol, no trans fat, no shellfish, no carrageenan, no GMO foods saturated with Roundup.
Nature created all of the locks, therefore Nature has all of the keys

xy123
Veteran Member


Date Joined Feb 2014
Total Posts : 644
   Posted 10/2/2017 5:22 AM (GMT -6)   
IamCurious said...

But I stopped taking it after more recent studies such as what you listed above show that daily glutamine intake can be problematic. But after my most recent flare I found that taking some glutamine seemed to speed up recovery. That is why my signature says I take glutamine only when I feel gut repair is needed after a flare, not regularly at all.


@IamCurious, I agree with you. You can also try drinking bone broth soup (especially at those hard times) because it is very helpful at healing the intestines.

--/--

Old Mike, are you there?
New Topic Post Reply Printable Version
Forum Information
Currently it is Tuesday, October 17, 2017 1:04 PM (GMT -6)
There are a total of 2,883,284 posts in 316,371 threads.
View Active Threads


Who's Online
This forum has 157496 registered members. Please welcome our newest member, luckylibra.
442 Guest(s), 16 Registered Member(s) are currently online.  Details
RedLabel, Rikky1, Pirouette, MelW11, Ellenalena, Serenity Now, Gear, Kat1000, gabybee, enginerd, Szabo246, Labradorite, Tall Allen, straydog, celebrate life, blueflame


Follow HealingWell.com on Facebook  Follow HealingWell.com on Twitter  Follow HealingWell.com on Pinterest
Advertisement
Advertisement

©1996-2017 HealingWell.com LLC  All rights reserved.

Advertise | Privacy Policy & Disclaimer