Omeprazole, doing more harm than good??

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Puggy77
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Date Joined Feb 2011
Total Posts : 17
   Posted 5/17/2011 9:32 PM (GMT -7)   
Ive been taking this for a couple of months now, it really helped at first, i was just glad to be out of the constant pain attacks that would keep me up all night. But ive found that while taking this i cant eat, well i can, but whatever i eat comes straight back up, be it 10 mins after eating, or 6 hours. The food that comes up is undigested, basically the same as it went down, and im left with the feeling of something stuck in my throat. Whatevers down there, i have to bring it up. Its not like im vomiting, just regurgitating it as i just cant keep anything down.

Question is, is it Omeprazole that is causing this or just part of living with gerd, or could i be ok now, whatever my problem was i can stop taking the pills? As part of what omeprazole does is to reduce stomach acid, and im thinking if its doing what its supposed to, maybe its stopping acid production all together or not enough, hence why my food is not getting digested and just sitting at the top of my stomach? I stopped taking them about a month or so ago to see if i was ok, a week later i was back to square one, i dont want to go through that again as it took just over a week for the pills to start working again. But im thinking these pills are whats causing me to keep bringing up what i eat, dont matter what food it is, its everything, from soup to solids, ive lost over a stone in weight this last month, feeling lightheaded and no energy all the time, i guess this is caused by me not been able to eat.

mudmagnetmum
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Date Joined Apr 2011
Total Posts : 1566
   Posted 5/18/2011 2:43 AM (GMT -7)   
Hi there
I don't think that's a very typical reaction to Omeprazole... BUT that's not to say it isn't as a result of taking the Omeprazole.

Did you try Ranitidine/Zantac as first line treatment?
Have you tried a lower dose of Omeprazole?
Have you tried any of the drugs that are used for motility disorder?
When you stopped the Omeprazole did the vomiting/reflux/regurg stop?

I would go back to your primary carer/GP and say that whilst the Omeprazole dealt with the original problem, you now have this new problem. I would definitely try some other drugs - you certainly can't continue like this. Either you are suffering a side effect or you have a new aspect of your original problem; a change of medication would help identify which it is. If you don't improve quickly on different medication then you'll need to see a GI consultant to get a more precise diagnosis.

Hope that helps.........

Puggy77
New Member


Date Joined Feb 2011
Total Posts : 17
   Posted 5/18/2011 7:24 AM (GMT -7)   
Thanks for the reply.

I was going to have a word with my gp next week at my next appointment and ask what other ppi's i could try as he diagnosed me with acid reflux. Along with the reflux i was also getting a killer pain, centre, just bellow rib cage and all around my back, was up a&e twice with it, i can just about handle the reflux, but the pain is a no no.

Opemprazole has been my first line of treatment and ive not tried a lower dose, but i did also think that, maybe im on to higher of a dose.
And ive not tried any other drugs either.
Did it continue when i stopped taking it? i guess so, just that the pain was back, and with that pain i get the reflux with it anyway.

Im saying that as it was the weekend just gone, i run out of pills on the saturday, since then ive not taken any as ive been able to eat and keep it down for a change. Thats why im thinking the pills are whats causing the reflux. I takes about a week of not taking the pills for the pain to come back so im in 2 minds now. Start taking the pills again and probably go back to not been able to eat, or not take the pills, carry on eating and fingers crossed the pain dont come back.

Ive not been to see a GI about my condition, yet as that is next on my list to try and get to the bottom of it all, instead of the doc just keep giving me pills which to me is just masking my condition, want to get to the root of the problem and a proper diagnosis.

stkitt
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Date Joined Apr 2007
Total Posts : 32602
   Posted 5/18/2011 7:38 AM (GMT -7)   
I am taking Opemprazole and most of the time it works well for me.  I agree you need to check in with your Dr.  I have not heard of anyone reacting as you have. 
 
I would strongly suggest you see a GI physician if you contiune to have problems with GERD.
 
Kindly,
Kitt
~~Kitt~~
Moderator: Anxiety/Panic, Osteoarthritis, GERD/Heartburn and Heart/Cardiovascular Disease.
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"If you can't change the world, change your world"

mudmagnetmum
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Date Joined Apr 2011
Total Posts : 1566
   Posted 5/18/2011 12:52 PM (GMT -7)   
Just wondering, also if you have been tested for Helicobacter? ? Your GP should have tested for that before starting the Omeprazole, as the drug interferes with the results.

You could experiment with a lower dosage of Omeprazole, or taking it alternate days, to see if you find a happy medium where you get enough benefit and minimum side effect. But basically you need to go and get your GP to work through the drug "trials" with you - keep pestering until you make some progress!

VeeZee
New Member


Date Joined May 2011
Total Posts : 1
   Posted 5/19/2011 8:00 PM (GMT -7)   
Puggy, I am like you in that I suffer similar symptoms. I get the reflux, and severe pain just below the rib cage. I also recently went off the Omep. And within one week my symptoms returned. I too have been wondering if the omep.  is adding to my symptoms rather than solving the problem. I am not sure what to do about this.

 I called my doctor and the only response was to renew the omep. for another two months and then go off of it again to see if symptoms return. I currently only take 20 mg per day. Similarly, I also feel light headed after taking it and sometimes experience mild nausea. It usually subsides after I eat an hour later. 

One thing that really concerns me was something my doctor's nurse said to me when she renewed the prescription, she told me that I needed to make sure to take a multivitamin because the omep. can prevent nutrients from absorbing in my system.  

 I asked, "Will it also keep my other medications from being absorbed?" She stated, "no it won't affect the absorption of your medications, only nutrients." This made absolutely no sense to me. I asked her if she was sure about that? She repeated it won't affect absorption of medications.  If that's the case, it explains why many here have posted that they have regurgitated  undigested food.

I also had the test for H. pylori bacteria and it came out negative. I really believe that unless I could get a referral to a specialist, I won't really know how best to treat this and what it really is, but these days it's almost impossible to get a referral to a specialist under most medical insurance plans.

 I read numerous other posts where people have made statements that consuming certain foods caused their condition. I can attest to the fact that sometimes I can eat a particular food consistently and I have no symptoms, and other times that same food can cause severe reactions. Whatever the cause and the best treatment is, I know that doctors have little to offer that can solve the problem, without causing others in its place.

I wish you luck in your continued treatment of this problem and I would appreciate hearing advice from anyone who has successfully evaluated and treated this disorder.

Puggy77
New Member


Date Joined Feb 2011
Total Posts : 17
   Posted 5/24/2011 3:41 PM (GMT -7)   
Well i went to doctors today, they are usless, i dont fancy at this time trying another form of medication as i really cant be doing with that pain again incase they dont work. So just said that i want referring to a gi specialist and explained all my symptoms, will probably take a month of so to get an appointment. I have not been tested for Helicobacter, maybe thats something i should of said and something to bring up to the gi. I to am on 20mg a day, i dont take any ther drugs at all, have my good and bad days, yesterday i had a couple of sandwiches and even managed a big mac and fries and all was good, today i had some sausage rolls and they ended up down the toilet, which i should no better as they never do stay down. Had a nice chicken and bacon roll for lunch and that was ok. So it really does depend what type of food i eat, and what time of day it seems, anything after say 6pm them im going to suffer, but most stuff throughout the day is ok. I think i should make a list of all the foods that dont agree with me. I will let you know it goes on and see if the gi comes up with answers for me.

mudmagnetmum
Veteran Member


Date Joined Apr 2011
Total Posts : 1566
   Posted 5/24/2011 4:09 PM (GMT -7)   
That's a shame they didn't test for Helicobacter - you need to be off ppis for a couple of weeks before they can test you, though if you have a gastroscopy they can take samples at the same time and test you then. You could try adding Ranitidine to see if that makes any difference, alongside the Omeprazole. Good luck with the consultant - hopefully you'll get some better answers there.
New stuff: GERD. Interstitial Cystitis
Lifelong stuff: Food allergies, eczema, asthma

Puggy77
New Member


Date Joined Feb 2011
Total Posts : 17
   Posted 5/25/2011 4:58 AM (GMT -7)   
I did have a couple of blood tests and urine done. They have all come back clear, wouldnt a blood test detected Helicobacter as i guess they would of looked for that anyway? I had one up the hospital when i first started getting the pain, and another a couple of days later at the doctors before i was prescribed omeprozole. Everything came back ok, dont ask me what they looked for as i dont know, he just said all looks fine.

And it got me thinking with what i said, im ok eating breakfast and lunch normally, dont have any problems. Its just come dinner time and any snacks i have in the late afternoon/evening. So ive been taking omeprozole 200mg, 1 pill per day at around 3-4pm, and its seems that after then the problems start?? So what im going to do is take my dosage just before i go to bed. See if i have a different results.

mudmagnetmum
Veteran Member


Date Joined Apr 2011
Total Posts : 1566
   Posted 5/25/2011 6:16 AM (GMT -7)   
Your blood tests would not necessarily include test for helicobacter and blood sample is not reliable for that anyway. Here in the uk I'm told they mostly test stool samples now for helicobacter.

I was much better taking my omeprazole at night rather than by day, though some days I felt it had worn off by around 4 pm. Unfortunately I had to stop it cos of skin rash, am now trying lansoprazole.
New stuff: GERD. Interstitial Cystitis
Lifelong stuff: Food allergies, eczema, asthma

Puggy77
New Member


Date Joined Feb 2011
Total Posts : 17
   Posted 5/26/2011 10:54 PM (GMT -7)   
Im in the UK also. My other doctor was great, i moved house last year to the other side of town and changed gp. im wishing i didnt now as they are useless. Ive just been up my old doctors and got a form to join back up, cant be dealing with this "dont care less" attitude of the doctor ive got at the mo.

Well, past 2 nights, took my pill at like 1am. During the day, no problems, kept all food down and been fine. :D

dencha
Forum Moderator


Date Joined Feb 2009
Total Posts : 6971
   Posted 5/27/2011 12:24 PM (GMT -7)   
Hi Puggy,

If your problem is worse at night, it could be because of laying down. Do you have the head of your bed elevated?

Are you vomiting the food up, or is it regurging on its own?

If it's regurging, I would suspect you have an open LES, and no matter what you take, food is going to make its way into your esophagus and mouth.

This is made worse when lying down, because gravity is no longer in play, and it's easier for things to move "upward" into your now level esophagus.

I would definitely not blame that on the Prilosec (omeprazole). PPI's can't keep food in your stomach...only reduce the amount of acid your stomach produces.

I'm glad to hear that you're making an appointment with your GI doc.

Are you taking the omeprazole an hour before dinner? That is when it will be most effective, as it shuts of the acid pumps before they get started.

Have you tried eating many very small meals rather than 3 bigger ones? Dinner (evening meal) tends to be the real culprit, as it tends to be the biggest one, and the closest one to bedtime.

I may be completely off base, and am misinterpreting your comments. If so, please set me straight!
Good luck,
Denise

Puggy77
New Member


Date Joined Feb 2011
Total Posts : 17
   Posted 5/27/2011 7:02 PM (GMT -7)   
Ive not yet elevated the bed, but i have read on many occasions that its a good idea to and i might do that over the weekend. Im not vomiting, its just regurgitating, like if i burp then food want to come up. And the problem is more or in the evening or at night. But ive not had that horrible pain in months now, sometimes i do get it buts its nowhere near as intense as what i had before. Just not been able to keep food down is the problem.

I was taking the omeprazole around and hour or 2 before dinner, but now ive moved onto around midnight to see if i have any different results, so far so good tbh, not really brought up any food in great amounts like i used to. I dont really eat big meals, a sandwich is about as big as it gets. If i was to have dinner it would consist of something like a burger and a handfull of chips.


"Edit"

I got letter through today, appointment on the 7th of june, pretty quick if you ask me.

I says ive got to stop taking omeprazole asap, 2 weeks before as they will be giving me a gastoscopy. The thing is, which is a catch 22 situation, i cant stop taking these. If i stop then im going to be in a lot of pain, and its just not worth it. I always thought toothache was the worst pain but this is something different.

Post Edited (Puggy77) : 5/28/2011 3:07:03 AM (GMT-6)


Puggy77
New Member


Date Joined Feb 2011
Total Posts : 17
   Posted 6/3/2011 8:53 PM (GMT -7)   
Well i didnt even make it to tuesday.

Spent all day yesterday up the hospital. Woke up around 9am and was fine, within 10 mins that familiar pain started, bottom of the chest and round the back, and just got worse and worse and started puking up that green bile/acid stuff.. I was hoping it would ease off, hot water bottle, hot shower seemed to work a bit, but after an hour i had to ring an ambulance. Was given gas/air as that put me out of the pain, which that pain stayed with me until around 3pm. After having x-rays, blood and stool tests which all came back ok apart from my liver looked a bit shabby, but not that bad to worry about so the doc said. They decided to let me go home with some pain killers and buscopan. I didnt even make it out of the pharmacy before the pain returned, and it went on like this for the next 3 hours, pain was intense, then dying down, then coming back. I had some morphine and some injection in was tummy which helped and was sent home around 9pm. I could of stayed in but the pain had gone, and was told if it returned then to come back. Straight home and straight to sleep and now ive just woke up ok, but so worried that pain will return, as i dont think painkillers worked, was just the fact that it passed by.

Still got to go in tuesday for the endoscopy and will also be booked in for an ultra-scan as the surgeon reckoned it was two things. Stomach ulcer or gallstones. Wouldnt surprise me if i had both. :(

Sometimes i think docs dont know much, i was told by one that omeprazole would take care of an ulcer and treat it, where ive been taking it for around 4 months you would of thought that an ulcer wouldnt be the problem, but then the surgeon says stomach ulcer?

And when i got back, the first thing i done, which what i should of done months ago, but me just be being ignorant, was stick some axle stands under my bed to raise it.

belle24
New Member


Date Joined Oct 2013
Total Posts : 1
   Posted 10/12/2013 9:02 PM (GMT -7)   
Hi there,

I am 30 years old and normally in really good health. Do lots of exercise, don't smoke, drink only a little bit and studying nutrition. 3 weeks ago I developed gastritis (well that's what the doctors think - it will be confirmed on Weds after my endoscopy booked). I think it was caused from taking neurophen on an empty stomach a few weeks earlier as I had been feeling headachey and run down. Very silly on reflection but I cannot now take it take. I also stress a lot about my study and probably have what everyone keeps telling me a type A personality.

I have have been really unwell for the last 3 weeks and after a trip to the hospital one night I was put on omeprazole. I have been taking it now for 10 days and it makes me feel awful. Still nauseous and weak because I feel the drug has completely taken away my appetite. I am worried about losing weight as am only 49kg at the moment.

From studying nutrition I normally tend to trust in science and doctors decisions but I have done a lot of my own research at the moment that says acid reducing drugs are very bad. I feel like someone is constantly putting their foot on the top of my stomach and is very uncomfortable and nauseating. I have basically had to put my life on hold and can't catch up with friends, my boyfriend and family are unsure what to do.

I would like to know the outcome of other people who have been through this as seriously thinking going off the drug. Like I said I was really healthy before and normally have a stomach of gold. If someone can share some hope or ideas with me I would be so grateful. Can you recover naturally from gastritis if they don't find that helicobactor in my tummy?

Never taking my stomach for granted ever again after this ordeal is over!

Please help :-)

lybbrown
New Member


Date Joined Nov 2013
Total Posts : 1
   Posted 11/8/2013 11:20 AM (GMT -7)   
I have suffered with severe acid reflux for over 30 years. I had no idea of the seriousness of this going on for so long. My father had it, other family members had it so I just thought it was normal. That was until everything started getting stuck in my throat (found out this was due to the fact my upper esophagus was like hamburger and swollen due to the acid damage.) I went to the doctor and long story short, I was diagnosed with Barrett's Esophagus as well as GERD. The doctor put me on omeprazole in May. It helped the symptoms of swallowing almost immediately, of course it helped the acid reflux too. However, after being on it for a few months I am starting to have all kinds of symptoms that after looking up the side effects, seem to be a cause of the omeprazole. Kindof like feeling like you are just starting to come down with the flu but it is all the time. Achiness, fatigue and lightheadedness that I am started to notice happens to get worse right after taking a pill in the morning. Since the properties of the drug take 4-5 days to get in your system I figured that the lightheadedness couldn't be caused by the drug since it happens so close to taking it. The doctor somewhat poo-poo'ed my complaints but changed me to protonic. But it sounds like taking Ranitidine/Zantac might be a better one to try since it is a bit different than the omeprazole. Has anyone had any luck with it. Oh, another symptom that I have is feeling like I have a lump in my throat when swallowing, not that the food gets stuck, just a weird feeling when swallowing. Has anyone experienced this? I am also wondering if there are alternatives to these PPI drugs. Osteoporosis runs in my family so the long term use of PPI's causing it, in and of itself, is very disheartening. Especially since I lead a very active lifestyle with horses/rodeo, which is a sport prone to injuries and accidents. In my lifetime I've had 4 broken arms, 2 fractured skulls, ribs, collar bones, etc etc. Any my bone density is good, as of now….I can't imagine what would happen after a fall if i had weakened bones.

Post Edited (lybbrown) : 11/8/2013 10:27:25 AM (GMT-7)


javery
Regular Member


Date Joined Sep 2013
Total Posts : 258
   Posted 11/8/2013 1:13 PM (GMT -7)   
I was on PPIs for almost 8 years before I finally realized the side effects of them. I didn't experience anything bad while on them but would eat until completely stuffed quite often. After learning that the drugs reduce your stomach acid to nothing in some cases, I wanted to stop taking them. Stomach acid is important to your health as it breaks down your food so your body can properly digest and absorb the nutrients. With little to no acid, your body isn't taking it what it needs to.

As research seems to do sometimes, one thing leads to another and you end up finding that something you would never have thought of, could be linked to the cause of the problem. Through hours and hours, across days and weeks, I have researched, and continue to research, the main cause of the problem. When I find something I like to research it to the point that if I find that through personal experiences of others, as well as proof from studies among testimonials from doctors, then I consider it a strong theory to consider.

Through my research, I have found that a lot of health problems may stem from grains, legumes, nuts, and seeds. My reasoning in this is due to two little things. Maybe not so little considering the amount of problems they may give us. Those two things are lectins and phytic acid. In a nutshell, lectins are able to make our antibodies attack cells in our bodies which create auto-immune disease among other things. Phytic acid, on the other hand, will prevent the absortion of nutrients. I consider lectins more dangerous as they seem to cause more problems. Phytic acid itself is not a major problem unless taking it in with other foods that you rely on the nutrients from.

I have been following the paleo diet and a lot of my research stems from the beliefs within that diet. To me it makes sense. So far I have been grain free for about 2 weeks and have noticed and improvement in my symptoms. I tend to only get heartburn inbetween meals when my stomach is empty. It seems to be getting better week by week. If you haven't researched the rebound effect of getting off of PPI's, it is something to be aware of.

With being on PPI's, or H2-blockers, your body will increase it's production of gastrin. Gastrin is what tells your body how much acid to produce. When your body senses it is not producing enough acid, such as blocking the acid with drugs, then the gastrin levels increase. When going off the drugs, especially cold turkey, then the heartburn comes back stronger than before. It's not completely known how long it takes for gastrin levels to return to normal but I have read in a study that it can take up to 26 weeks. I have also had my doctor say this is true as well. I am currently almost at the end of week 7 from being off PPIs and think it is working so far. I'm keep track of my progress and am hopeful to be completely symptom free within 6 months.

I know that information can be deciphered different ways by different people based on person experience or beliefs, but through my research, I believe my symptons are caused by my diet. This may or may not be the case, but it is the gamble I'm taking. So far it seems to be working. I'm hoping this information will be able to help some of you with your symptoms. Although drugs seem to mask the symptoms quite quickly, our bodies do take time to heal for the symptoms to go away. I believe if you give your body what it needs to heal, things will get back to normal. To me, giving up a lot of good foods is well worth living a pain free life so I can enjoy my hobbies much more.

corgislover
Regular Member


Date Joined Oct 2013
Total Posts : 22
   Posted 11/9/2013 11:01 AM (GMT -7)   
I'm fairly new to this forum but I wanted to give my experience with omeprazole. I was taking 40 mg morning and 40 mg night (30 minutes before breakfast; 30 minutes before dinner). My symptoms got worse. I had nausea, horrible water brash, very loose bowels and my stomach hurt. I quit taking it and called the doctor's office and was told to try asiphex. Previous to this I tried Nexium and Dexilant. I had extreme tiredness, leg cramps and other symptoms so I stopped taking those meds too. None of these meds helped me with acid reflux. I just ended up with more symptoms. I don't want to take the asiphex because I don't want even more symptoms to deal with. PPIs just don't seem to be working for me. I know we're all different and they seem to work for some people, but not others.

I have been diagnosed as having GERD and LPR. My general practitioner told me that if the PPIs don't work, he wants me to go to a surgeon. I would much rather work this problem naturally, preferrably with diet. I've already changed my eating to comply with what most doctors recommend for acid reflux. In addition, I given up dairy, eggs, and wheat. My bed is elevated, I eat small meals, don't eat before bedtime, etc., etc... So far, nothing has helped with the acid reflux and water brash.

Next up for me is a vegan diet. I have Dr. Koufman's book Dropping Acid and am into my second week of her diet but it's not a vegan diet. I've had less acid (encouraging), but doesn't touch the rest of my symptoms - yet. Just ordered Forks Over Knives (DVD and cookbook). Should get it next week. I'll keep you posted on whether this helps me or not. I really don't want to go under the knife (the irony of the name of the DVD just hit me) and am hoping to be a success story one of these days. It's very discouraging to have tried so many things and still be at square one after 2-1/2 years.

The best thing that has happened to me so far is finding this forum. I haven't posted much but I read just about everything that's submitted daily. You have all helped me very much and I've been encouraged to keep on trying.
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