PPIs causing anxiety and depression?

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Noelle3
Regular Member


Date Joined Sep 2013
Total Posts : 154
   Posted 10/29/2013 6:45 AM (GMT -6)   
I was wondering if any of you have found that PPIs made you anxious and agitated?

This illness is anxiety provoking at times anyway, however, I think the PPIs are making me highly anxious and agitated. It's as though I have a slight nervous tremor in my body (don't know if that makes sense) a lot of the time.

I just looked up the Patient Information Leaflet to check this out and it states under Rare side effects: Feeling agitated, confused or depressed.

Any thoughts?

Baza
Regular Member


Date Joined Jan 2011
Total Posts : 395
   Posted 10/29/2013 7:23 AM (GMT -6)   
Hi Noelle3, can I ask which ppi you are taking? I have had lots of problems with nexium through the years.Not on any now by the way. Barry

ed@mtl
Regular Member


Date Joined May 2013
Total Posts : 37
   Posted 10/29/2013 10:14 AM (GMT -6)   
Nexium caused depression for me. I'll never take those again ever!

Noelle3
Regular Member


Date Joined Sep 2013
Total Posts : 154
   Posted 10/29/2013 11:44 AM (GMT -6)   
Hi Barry, I'm taking Nexium.

Hi ed@mtl, are you taking any other PPI instead of Nexium?
Symptoms of reflux started on 8th May after taking one Bisphosphonate tablet. I had never suffered reflux in my life before this date.
Osteoporosis

Baza
Regular Member


Date Joined Jan 2011
Total Posts : 395
   Posted 10/29/2013 12:45 PM (GMT -6)   
Hi Noelle,i thought you might be taking nexium.I had depression and felt a lot of agitation on nexium aswell as other issues.Doctors wouldn't listen,tried to give me antidepressants when I knew it was the drug because everytime I stopped it all the symtoms vanished.
I would try another ppi to see who you feel,there are a few others you can try. Barry

Noelle3
Regular Member


Date Joined Sep 2013
Total Posts : 154
   Posted 10/29/2013 2:27 PM (GMT -6)   
Hi Barry, I tried two others before Nexium. I started on Omprazole which gave me really bad headaches and made me feel awful. Then was put on Lansoprazole. I can't recall if it caused side effects, but it didn't control the reflux so I was put on Nexium which I believe is the strongest.

The thing is that none of them have really worked anyway, so all I'm getting are the side effects!

I even tried Ranitidine but it gives me insomnia. The only thing left I think is the old fashioned Tagamet, but as it's a H2 blocker like Ranitidine, it too may cause insomnia. I'll be seeing my GP on Friday and see if she has any bright ideas. The thing is she seems amazed that the PPIs aren't working! If this forum is anything to go by, it seems like a more common problem than she realises.

TheSiXness
Veteran Member


Date Joined May 2012
Total Posts : 519
   Posted 10/29/2013 2:35 PM (GMT -6)   
just a side note, if your going to be put on anything for depression... many of the antipsychotic meds do cause GERD. Maybe start at a low dose and than go by how you feel. Does anyone know a decent anti depression med that doesn't give them side effects?

Also, Nexium gave me depression too. I think protonix makes me depressed and a little bit more angry also.
-TheSickness-

KitKat880
Regular Member


Date Joined Apr 2012
Total Posts : 108
   Posted 10/29/2013 7:55 PM (GMT -6)   
Omeprazole made me incredibly anxious and often depressed, more so than my LPR did on its own. My internist insisted the medicine was not the cause, so he put me on Lexapro (20 mg). It didn't seem to make my LPR any worse, but I didn't take it long term, just for a month or two. When I finally saw a GI doc, he switched me to Dexilant, and the psychological issues went away. The Lexapro went in the trash.

Baza
Regular Member


Date Joined Jan 2011
Total Posts : 395
   Posted 10/30/2013 2:13 AM (GMT -6)   
Hi Noelle,i found that I had a lot less side effects on ranitidine,i know what you mean about the insomnia but did you stay on it long enough? I found after a couple of months I got used to it and I only woke maybe once or twice in the night.
I know its very hard for some people with the drugs,some are really sensitive to them and I am one of those like yourself.If you have reflux you have no other choice but to protect yourself though. Keep trying until you find something you can live with. Barry

Noelle3
Regular Member


Date Joined Sep 2013
Total Posts : 154
   Posted 10/30/2013 6:14 AM (GMT -6)   
Barry, the consultant (registrar) advised my doctor to prescribe Ranitidine because the PPIs weren't helping that much and secondly because I have Osteoporosis and there is a small risk of fracture with them due to not being able to absorb enough bone essential nutrients like calcium etc.

I didn't stick with the Ranitidine for long and only at 75mg twice per day and even at that low dose they caused problems. Can you remember what your initial side effects were on them and how long it took for them to subside?

By the way, congratulations on getting your Nissen re-do. I was following your journey on other threads. Hope you're recovering well.
Take care.
Symptoms of reflux started on 8th May after taking one Bisphosphonate tablet. I had never suffered reflux in my life before this date.
Osteoporosis

Noelle3
Regular Member


Date Joined Sep 2013
Total Posts : 154
   Posted 10/30/2013 6:15 AM (GMT -6)   
Thank you everyone for your responses .. they are very much appreciated :-)
Symptoms of reflux started on 8th May after taking one Bisphosphonate tablet. I had never suffered reflux in my life before this date.
Osteoporosis

Baza
Regular Member


Date Joined Jan 2011
Total Posts : 395
   Posted 10/30/2013 7:18 AM (GMT -6)   
Hi Noelle, I was taking 150mg of ranitidine twice daily,one in morning and at bedtime.The first 3-4 weeks a lot of wind,burping,and stomach upset and trouble sleeping but it all settles down into the second month.I have found similar effects from all ppis and h2 blockers,they take weeks to settle.
Definitely stronger effects from the ppis,i can only assume they deplete your body from certain vitamins and minerals.Ive had b12 and folic acid deficiencys in my past which was very unpleasant,also hard to get diagnosed.Doctors just don't believe you! Barry

gbaby08
Regular Member


Date Joined Apr 2013
Total Posts : 46
   Posted 10/30/2013 8:37 AM (GMT -6)   
I am feeling super anxious on Omeprazole. I have anxiety anyway, but this has magnified it by 200%. I have been taking it faithfully for over a week now and the past few days have been horrible for me. Anxiety, almost going into panic attacks, not being able to swallow (my physical symptom from anxiety), stomach pain, muscle twitching underneath my chin and insonmia.

I am stopping as of today and consulting with my doc.
Gbaby
-----------------
Panic Disorder/GAD, Silent reflux
Meds-Klonopin, Zoloft, Fish oil, B12 and Magnesium

Pie_Filipina2013
Regular Member


Date Joined Nov 2013
Total Posts : 42
   Posted 11/2/2013 12:30 AM (GMT -6)   
Hi everyone. I am new here. I was just diagnosed with GERD. I have maintenance for my asthma - Seretide spray (had it when I was toddler and resurfaced when i was in the 40's), i have allergic rhinitis and sinusitis (have Avamys spray). I am allergic to crabs, squid, shrimps.

I had few episodes of stomach upset and acid reflux before but those were easily relieved by Kremil S or Gaviscon. Last July, I was rushed to the ER due to allergic rxn to squid. After that, I was very choosy already with what I eat and at sometimes get panicky eating outside because I wouldnt really know if it has shrimp paste or anything that would make me allergic to.

One night, I just noticed my voice got hoarser and hoarser until i almost lost it. It got relieved by just taking Bioflu and hot calamansi juice (its a kind of lemon; i am from the Philippines).

Everything was okay, although i noticed that there were time that i feel my throat got constricted and will just take antihistamine. Then i noticed it got severe, i would still take antihistamine since my sinuses were acting up also. Went for consult since one time, i was so edgy and attributed it to sinus infection. The doctor put me on Zithromax 500 mg for 5 days.

On the 8th day after Zithromax, after taking breakfast with coffee and had my usual Claricort, i felt my throat constricting again. I rushed to the ER and was informed that everything is okay, i am just panicky and this could be nasal drip and GERD. I was so anxious the whole day. I even went to the mall with my husband but went instead to visit a clinic at the mall and still was told okay. The doctor however referred me to see an EENT which i never did.

When i went to see our company doctor, she put me on Nexium and Claritin. My throat still feel dry and constricted but all doctors told me i dont have any wheezing sound and my breathing is normal. All doctors advised me to just relax. I think this is better said than done.. Only those with GERD can understand what I am going through. At this time, i have not experienced any upset stomach, just dry throat, palate and stomach until i had camote (sweet potato in the Philippines; a root crop) as subtitute for rice. That is when I had two very restless nights.

Last Tuesday night, i went again to the ER because I had this feeling of wanting to burp but cant and this feeling of something being stuck in my throat and the doctor told me its GERD and bilateral maxillary sinusitis - i had Waters x-ray. Changed Nexium to Pantoloc plus Gaviscon chewable every after meals and prescribed Augmentin 625mg 3X a day for 7 weeks and Nasathera 3X a day..She also gave me Xanor to calm me down. My ECG at the ER was fine. By the way, i am overweight and hypertensive. I have been taking Twynsta 80/10 for more than a year now. I have Grade 1 diastolic dysfunction also. I slept well that night.. No epigastric pain.

Wednesday morning was great.. by midafternoon i had again that feeling of something being stuck in my mouth. I had a very restless night, i cant really describe how my stomach was acting.

I went this time to see a gastroenterologist. She changed by Pantoloc to Dexilant. She prescribed Xanor to me 250mcg at bedtime or as needed. I was able to sleep Thursday night but had to be up early because we are going home to the province.

When I got here yesterday, the symptoms were up again, i had to take Xanor 250mcg at 4pm to keep me calm as i was also finishing reports. Regurgitation is back and I think i was only able to sleep for 2-3 hours. My stomach is still acting weird and my mouth/saliva is so sour/acidic. I was able to sleep another 2 hours this morning - its November 2 here already and its 2:25Pm now.

Most of my friends cannot understand- they think I am just over acting to a lot of things that is why my stomach acid is also over acting. My boss even told me that it is purely psychological. My sister can relate to what im feeling though because she had gallstones before. she underwent surgery to remove her gallbladder about 4 years ago but still experience GERD. My mother has gallstones but because of her age, the doctor didnt advised to have her gallbladder removed. My other brother had his gallbladder removed also a few years earlier than my brother.

What makes me panic is the feeling the my throat is closing. I had the same feeling when i had an allergic attack. I lost weight already since the allergic attack and because of this GERD i also dont feel like eating. My gastroenterologist told me that GERD suppresses appetite also. but i think its more of the PPI's fault plus being anxious and all.

This is a very lenthly post i know. I just want to write down everything that i experienced. By the way, with Nexium, i also experienced tingling of the upper lip and feeling of body malaise and dry mouth and dry palate and anxiety attacks.

I am scheduled for an endoscopy on the 15th by the way. Maybe i will even have this moved earlier so that based on the results proper medication can be given.

Thank you all. I really appreciate this site. I wonder if there are other Filipinos here too.

Migz27
Regular Member


Date Joined Oct 2013
Total Posts : 20
   Posted 11/2/2013 12:52 AM (GMT -6)   
Hi!!pie.. I am a filipino also working here in abroad.. I do have esophageal reflux also.. I also feel that my throat is closing and its hard because i'm alone here.. Update us after your endoscopy.. I too will have my endoscopy soon.. Maybe next month..

Pie_Filipina2013
Regular Member


Date Joined Nov 2013
Total Posts : 42
   Posted 11/2/2013 4:11 AM (GMT -6)   
Hi Migz,
 
I am currently in Negros Oriental but actually working in Cebu.
 
Sure I will.  Two of my siblings had their gallbladder removed already.  My sister can identify what im going through but she's in Bohol right now assigned as a social worker.  My mama also has the same "sickness".  My sister and I just communicate through text.  Since Im now home for a vacation, may mama has been introducing me to a lot of herbal medicine.  From what province are you from in the Philippines?
 
do you have allergies also?  GERD and allergies are cousins i think and post nasal drip as well. hehehehe.  My GI has prescribed me Zanor for my anxiety attacks.  I was really scared at first, good thing i came across of this forum and it has opened my eyes to a lot of things about GERD. 
 
The feeling of your throat closing is just a "feeling".  I have been to the ER 3X because of that feeling.  I thought i was having an allergic attack after having eggs for breakfast and coffee and beef strips (c/o Jollibee..hehehe). I am never allergic to eggs! Im only allergic to squid, shrimps, crabs.  I can even eat green mangoes and bagoong. It was just a panic attack but the throat discomfort didnt go away and its been 3 weeks now.
 
Especially if you're from the province, there are limited data about GERD.  My cousins are even suggesting I go and see and "albularyo" (faith healer or a "medicine man".)  The reason perhaps is because most if not all of those with GERD also experience panic attacks/anxiety attacks.  My cousin's husband got well after seeing an "albularyo".  The treatment comprised of some "oil" being rubbed on the stomach and a list of foods to be avoided.  The price asked back then, about two years ago was 163.00 US dollars in one visit.
 
The only setback i have is insomnia.  I plan to buy the wedge pillow so that my head will be elevated when i go to sleep.
 
Take care.
Pie
 
- i think im pre-menopausal also; im hypertensive; asthmatic and got allergic rhinitis and perennial sinusitis.

Post Edited (Pie_Filipina2013) : 11/2/2013 4:15:48 AM (GMT-6)


Pie_Filipina2013
Regular Member


Date Joined Nov 2013
Total Posts : 42
   Posted 11/12/2013 1:07 AM (GMT -6)   
Hi Migz,
I was confined in the hospital because i was suffering from insomnia already and it was driving me nuts! I went through a lot of tests, ultrasound and other labs done were unremarkable thank God but had my endoscopy which showed esophagitis and hyperemic gastritis.

I would always over react when it comes to health issues so when i told my gastroenterologist i might panic during the procedure she suggested that i would be sedated. I want to be fully conscious however when its being done so she gave me 250mcg Xanor Friday night since the procedure was on Saturday morning. When the nurse explained to me that they are going to spray and anesthesized my throat down i felt uneasy already. When the liquid trickled down my throat i thought i cannot breathe anymore and i panicked. my doctor patiently explained to me that im doing well and my oxygen level was 100% but i was really shaking so she had to call an anesthesiologist and partly sedated me. Its was really an "experience" but a quick one like normally it would last 3-5 minutes only. I think it would be best if you will be half or fully sedated.

I am still on Dexilant 60mg and will be seeing my doctor again this saturday. When the typhoon hit our place (Cebu city) I was at the hospital fully safe. Im sure you have seen footages of the devastation the typhoon brought in Tacloban City.

The burning sensation is still there, the lumpness in the throat is still there.. the PPI is making me lethargic. I tried my best not to take Xanor to help me put to sleep since the lumpness feeling would always wake you up at night.

The endoscopy results has somewhat relieved me of my anxiety because the GERD diagnosis at first was only based on symptoms presented. Now, what i need to face is that reality that the healing period might be long.

We still need to be thankful though. We need to accept and live with this and not let GERD ruin our life.

A psychotherapist has given me a meditation link which i've been practicing. He suggested i will try this first for two weeks before i go and see him since according to him most anxiety attacks can be controlled through meditation.

I've tried last night taking aloe vera juice and the acid-sour taste has resurfaced. A friend who has been using aloe vera for many years explained that its part of the healing process. I will stop tonight taking this and talk to my gastroentorologist if this is safe. This is not the first time for me to take aloe vera juice though. I always believe in its healing benefits.

I would say meditation is very helpful - they also call it as mindfulness or being aware of the "present". Its very simple but your mind tend to wander and you go back again to your breathing awareness.

I was going through my health record at our company clinic and noticed those many times I seek consult for post nasal drip and hoarseness. That could be GERD already and since it was not diagnosed and would take lozenges or take hot citrus unaware that i was aggravating it.

I hope everything is okay with you now.

Pie

opnwhl4
Forum Moderator


Date Joined Dec 2008
Total Posts : 4721
   Posted 11/12/2013 1:14 AM (GMT -6)   
The 2 meds that had the least side effects for me were Dexilant and Pepsid. I actually haven't had any side effects while taking Pepsid. While I no longer need it, my wife uses Pepsid with very good results.

Take care,
Bill
opnwhl4
Moderator: GERD/Heartburn, Kidney disease

Nissen 6/06 and 5/09
#3 8/24/11

Pie_Filipina2013
Regular Member


Date Joined Nov 2013
Total Posts : 42
   Posted 11/13/2013 4:24 AM (GMT -6)   
Hi there,

I actually started with Nexium - prescribed by our company doctor then had Pantoloc for 2 days via ER doctor and when I went to see my Gastroenterologist about about two weeks ago, she changed it to Dexilant.

My only problem is difficulty having a good night's sleep - thought it is insomnia and i just realized today its the acid reflux that would wake me up at night. Thanks to all the people who shared their experience about GERD. I am buying a wedge pillow tomorrow, I hope this would help.

Is there any particular dimension that i need to consider?

Thanks.
Pie
GERD - ESOPHAGITIS, GASTRITIS, HYPERTENSIVE
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