Safety data In general, all doses of pantoprazole were well tolerated. The proportion of patients with treatment-emergent adverse events in the pantoprazole 40 mg group was higher than in the other treatment groups (P < 0.05), but patients in this group also had the longest duration of exposure because of a difference in withdrawal rates. Headache was the most commonly reported treatment-related adverse event among patients receiving pantoprazole (14%), but the occurrence of headache was not statistically significantly different from that seen in the ranitidine group (8%; P = 0.127). Fourteen per cent of patients treated with pantoprazole reported headaches versus 8% of patients in the ranitidine group. Although the percentage of pantoprazole treated patients reporting headaches is higher in this study than in previous studies, there is no dose trend (pantoprazole 10 mg 11/88 [13%]; 20 mg 9/93 [10%]; 40 mg 18/94 [19%]; P = 0.18). There was a significant difference between treatment groups in withdrawals due to adverse events (P = 0.006), but this effect was not dose-related among patients receiving pantoprazole. The percentage of patients who discontinued because of adverse events was 1% for the pantoprazole 10 mg, 13% for the pantoprazole 20 mg and 3% for the pantoprazole 40 mg groups, and 6% for the ranitidine group. No deaths occurred during the study and the incidence of serious adverse events was not significantly different between treatment groups. No clinically important changes in laboratory test results and vital signs were noted (data not shown).
Read the whole study: http://www.ppi-studies.com/05.html
I couldn't stay on the PPIs long enough to get addicted because the migrane like headaches start within two days of taking them along with a myriad of other debilitating side effects.
I can't relate to how anyone can stay on them long enough to get addicted, but I'm not surprised one can.
Im experiencing these same symptoms from withdrawing from prilosec, including acid rebound (big time!!!), headaches and shakes.
Welcome to HealingWell and the Gerd forum. I have never used Protonix however if you are starting to have new sx you may want to check in with your physician.
Do stick with us as we have lots of members with a great deal of knowledge.
We also have a welcome forum if you would like to post a bit about yourself.
Again a warm welcome.