Protonix Withdrawal Symptoms-What they don't tell you

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bekster
Regular Member


Date Joined May 2006
Total Posts : 73
   Posted 8/7/2006 6:42 PM (GMT -6)   
First of all, the correct word is withdrawal. Yahoo ran a story on how people who want to cannot get off Paxil (Paxil and Protonix are made by the same company, Wyeth). I read it to find out how the pharma companies trick doctors into prescribing something clearly addictive to their desperate patients:
 
I highly recommend this article for those who still believe these companies care about us. If you have already lost your innocence, read the testimonials of people who have managed to get of this antidepresant and you'll see the parallels to our situation:
 
 
Afyter tapering off the dosage for about four months, I quit the ten mg I was taking for a month. I had no stomach symptoms but I started having these successive migraine-like headaches that resembled MSG, morphine or champagne headaches. They would come out of the blue, and dissapear out of the blue. I'd get a break for as day, then they would return. Only OTC migraine medication would diminish the pain in any significant way. I was going crazy, but not thinking withdrawal because my research had not yielded anything remotely similar to headaches. There is very little on the subject of (God forbid!) quitting your PPI out there.
 
But then I ran into this study detailing the withdrawal symptoms of subject who underwent a treatment of 10, 20, and 40 mg of Protonix for several months, and, you guessed it, the most common complaint upom withdrawal was headaches. Notice how they don't even refer to them as migraines:
Safety data
In general, all doses of pantoprazole were well tolerated. The proportion of patients with treatment-emergent adverse events in the pantoprazole 40 mg group was higher than in the other treatment groups (P < 0.05), but patients in this group also had the longest duration of exposure because of a difference in withdrawal rates. Headache was the most commonly reported treatment-related adverse event among patients receiving pantoprazole (14%), but the occurrence of headache was not statistically significantly different from that seen in the ranitidine group (8%; P = 0.127). Fourteen per cent of patients treated with pantoprazole reported headaches versus 8% of patients in the ranitidine group. Although the percentage of pantoprazole treated patients reporting headaches is higher in this study than in previous studies, there is no dose trend (pantoprazole 10 mg 11/88 [13%]; 20 mg 9/93 [10%]; 40 mg 18/94 [19%]; P = 0.18). There was a significant difference between treatment groups in withdrawals due to adverse events (P = 0.006), but this effect was not dose-related among patients receiving pantoprazole. The percentage of patients who discontinued because of adverse events was 1% for the pantoprazole 10 mg, 13% for the pantoprazole 20 mg and 3% for the pantoprazole 40 mg groups, and 6% for the ranitidine group. No deaths occurred during the study and the incidence of serious adverse events was not significantly different between treatment groups. No clinically important changes in laboratory test results and vital signs were noted (data not shown).
 
Read the whole study: http://www.ppi-studies.com/05.html 
So 13% of people atking 10 mg of this PPI reported headaches! I am writing this during a rare break from suffering. I don't know how long this lasts... All comments welcome.

ilovecats94
Regular Member


Date Joined Jul 2006
Total Posts : 190
   Posted 8/11/2006 4:07 AM (GMT -6)   
Bekster, I have been posting that I was thinking of trying Protonix to see if it would heal up my erosive esophagitis since I have been on Nexium 40 mg. now for almost 4 months.  I'm better, but I should be sleeping now and not up after being in bed for an hour.
 
My husband has been on Protonix for over 4 years without trying to get off of it and I told him the medicine wasn't meant to be taken that long.  He just ignores me and as long as his doc will give him refills he continues to take it every morning. 
 
Now I've been wondering if I could heal up faster on Protonix as I'm struggling with side effects from the Nexium, the worst being edema in the feet/legs/hands.  I'm at the point where walking is painful and yet I'm trying to lose weight, but I can't because I can hardly do much of anything.
 
I'm finding only Lortabs will help me with the heartburn/chest pain of GERD along with Tums.  I'm up until 2 AM or so and we finish eating dinner at 8 PM, so I'm giving myself plenty of time before I go to bed. 
 
I guess it is back to the drawing board and maybe I'm better off to stay on the Nexium rather than risk the side effects of headache and withdrawals with Protonix? 
 
Thanks for the info, Bekster, I do appreciate it.
 
Hugs,
Faye
Hypothyroidism (1958), Diabetes type 2 (1976), Hypercholesterolemia (1989), Gastroparesis (1990), FMS (1995), and GERD (2006).


sarah12
Regular Member


Date Joined Jul 2006
Total Posts : 29
   Posted 8/11/2006 7:52 AM (GMT -6)   

I couldn't stay on the PPIs long enough to get addicted because the migrane like headaches start within two days of taking them along with a myriad of other debilitating side effects.

I can't relate to how anyone can stay on them long enough to get addicted, but I'm not surprised one can.


bekster
Regular Member


Date Joined May 2006
Total Posts : 73
   Posted 8/11/2006 11:18 AM (GMT -6)   
Ilovecats, I am not a doctor. I am posting to provide other people with my experience so they can form their own opinions. That said, I notice two things. Every PPI does not work the same way. If Nexium isn't doing it for you, consider switching. PPIs do have a role in assisting the healing process of someone with erosions or even irritation to the esophagus. I will take Protonix again if I relapse into a crisis, never mind the headaches.

The second thing I see is that you might be having dinner way too late for someone in your situation. I trained myself to eat dinner at four for almost four months, until my symptoms subsided enough to enable me to have dinner later. Right now I do not eat after six. It's just not good for you or your digestive system to consume food so late. Keeping the regularity in your sleeping patterns is much more important.

One more thing, watch what you eat and you'll get better quicker, or at least your symptoms will not be as severe. Good luck with the switch, and keep us posted.

ilovecats94
Regular Member


Date Joined Jul 2006
Total Posts : 190
   Posted 8/12/2006 12:13 AM (GMT -6)   
Thanks, Bekster. I'll talk to my husband about eating earlier. He does the cooking. I am trying to stay on a GERD diet. Except I do drink diet drinks early in the afternoon, then I go to water and then Crystal Light.

Also I will think of switching from Nexium to Protonix. My husband takes Protonix.

I am seeing a family doc for the treatment of the GERD. I'll let you know what I do. I may just call the doctor and get him to write an Rx for the Protonix for me to try for a month or so.

I tried to go without the Nexium tonight and I right away had heartburn so had to take the capsule. I stopped the flax seed oil capsule in case that was causing irritation.

I'm going to try to go to bed. If I can't, I'll be back up on the computer again. :-(

Thanks for your help.

Hugs,
Faye
Hypothyroidism (1953), diabetes type 2 (1976), hypercholesterolemia (1989), gastroparesis (1990), FMS (1995), and GERD (2006).

FMS: Prozac, Xanax, Diclofenac, Cytotec, Lortab.

Other meds: Nexium, Cytomel, Detrol, Reglan, Novolog insulin, Novolin N insulin, Bumex, Lipitor.


bekster
Regular Member


Date Joined May 2006
Total Posts : 73
   Posted 8/12/2006 8:24 PM (GMT -6)   
Hi Faye, The aspartame in some of those drinks gave me terrible reflux, I had to stop it, ditto for the sugarless gum : ( It took me months to get adjusted to new habits, and I still struggle. I think the hardest thing for me is to eat "small" meals. One way I trick myself is to eat something 20 min before dinner or lunch, then it does curb my desire to eat more. Another thought: With a very low fat diet, I lost 22 pounds in four months, without exercising. I was not doing much exercise because I was feeling so rotten, but my diet was doing it for me.

Nal
Regular Member


Date Joined Jan 2006
Total Posts : 410
   Posted 8/14/2006 12:14 PM (GMT -6)   

Im experiencing these same symptoms from withdrawing from prilosec, including acid rebound (big time!!!), headaches and shakes.

 

Nancy


bekster
Regular Member


Date Joined May 2006
Total Posts : 73
   Posted 8/14/2006 3:15 PM (GMT -6)   
Hi Nancy, did you slowly taper off the dose? If you did, maybe it's not rebound. My doctor says tapering off the dose "should enable anyone to get off a PPI without any problems."

Nal
Regular Member


Date Joined Jan 2006
Total Posts : 410
   Posted 8/14/2006 3:59 PM (GMT -6)   
No, I have not been tapering off as slowly as I probably should.  However keep in mind that none of my stomach pains ever started until I STARTED Prilosec in the first place!   I should have listened to my instincts then and quit taking it but instead I chose to go through hundreds of tests with no real answers ever.
 
That said, I know these are withdrawl symptoms.  Hope I get through it quickly and I will slow down on tapering the dose.
 
Nancy

mcooley
New Member


Date Joined Feb 2008
Total Posts : 1
   Posted 2/14/2008 11:44 AM (GMT -6)   
I have been on Protonix for more that 10 years and it is wonderful drug. It controls my GERD very effectively. It took me forever to come to realization that I was experiencing side effect. I usually take 40 mg every morning and I started getting severe migraine-like head aches. I now know that if I do not get that pill within a few hours of my dosage time, I am in for very bad day. It is completely dehabilitating. The only thing I can do is pace back and forth in a dark room with a warm compress on my head.

TammyGrl0528
Veteran Member


Date Joined Jun 2007
Total Posts : 1345
   Posted 2/14/2008 12:11 PM (GMT -6)   
Hello mcooley, and welcome aboard! I am glad you have found such relief with Protonix, and I am happy you feel comfortable enoughto post here.

Please do stick with us, and share your story...also, feel free to look at old posts for suggestions and ideas that may further help you out.

Wishing you the best.

And, I am sorry to hear about the migraine like headaches...have you talked with your doc about this?
 GERD Forum Moderator
    Please share, only if you can spare! 
 Diagnosed with Generalized Anxiety Disorder (GAD) and Panic Attacks.
 Clickable Link that may be of interest to some...as I find I often like to check drug interactions...Drug Interactions
 
~Tammy~


marthamae
Regular Member


Date Joined Jan 2008
Total Posts : 285
   Posted 2/14/2008 4:32 PM (GMT -6)   
If there's one thing I've learned in all my time on earth, it is this: one man's drug is another man's poison. Some people are literally saved by drugs and have no side effects and go merrily on their way. Others struggle on a very tiny dose. It's so hard to tell.

No one "wants" to take any more medicine than they have to. But if you have a real medical condition that is impacting your life, I say try a recommended drug for a short time. Just because someone else developed a side effect from it, doesn't mean you will. You have to weight the benefits vs. the risks.

I suffer from serious depression and have taken many different drugs over the years. Some have had crappy side effects and others have not. The drugs have also constantly gotten better and more "fine-tuned" as time has gone on. But I just kept trying until I found the right drugs for me. I've lived a decent life because of meds and I am grateful they are around. I've seen a lot of people in the mental health system who refuse to take their meds and no one that I am aware of had a good outcome. Meds are not all bad.

Binx
New Member


Date Joined Feb 2008
Total Posts : 1
   Posted 2/19/2008 4:28 PM (GMT -6)   
Has anyone had the side effect (ringing and hissing in the ears) when taking protonix.
I tried just about every ppi out there. and seem to get the same reaction. Protonix seems to work the best but the hissing in my ears is terrible. I also feel very weak in the legs. I just feel horrible whenever I'm on any one of them.
JanetG

Alycarr00
Regular Member


Date Joined Nov 2007
Total Posts : 65
   Posted 2/25/2008 10:26 PM (GMT -6)   
Just my 2 cents

I was on 40mg protonix for a few months, then bumped up to 40mg twice a day. I had my lap nissen 4 weeks ago and have not been on protonix since. I have had NO side effects from coming off the meds.....
***~Alli~***


beckbing
New Member


Date Joined Jan 2009
Total Posts : 1
   Posted 1/26/2009 4:46 PM (GMT -6)   
Hi, I'm new at this. So, be patient with me. I am just recently coming off Protonix. I've been on it for coming close to two years. Had to after Gall Bladder surgery. This is my fourth day not to take it. Last week I came off every other day and now like I said my fourth day with out it. Just wondering if I will eventually just feel fine without it and wondering what some of the withdrawl symptoms are for others. I am starting to have a thickness feeling in my throat after eating and dizzy spells out of no where. I am wanting to stay off the med. I have heard that you can run the risk of stomach cancer by staying on Protonix too long. Sure don't want that to happen. But, on the other hand I don't want to go back to having severe reflux and stomach aches every time I put something in my mouth. Any help out there?

LdyJane
Veteran Member


Date Joined Jun 2008
Total Posts : 903
   Posted 1/26/2009 5:45 PM (GMT -6)   
I don't have an answer for you Beck; I was on Protonix for 3+ years and stopped after my Nissen without a problem. I hope you feel better though!

stkitt
Forum Moderator


Date Joined Apr 2007
Total Posts : 32602
   Posted 1/28/2009 4:58 PM (GMT -6)   

beckbing

Welcome to HealingWell and the Gerd forum.  I have never used Protonix however if you are starting to have new sx you may want to check in with your physician.

Do stick with us as we have lots of members with a great deal of knowledge.

We also have a welcome forum if you would like to post a bit about yourself.

Again a warm welcome.

Kitt


 

Kitt, Co-Moderator: Anxiety/Panic & Depression
&  Moderator GERD  Forums

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http://www.healingwell.com/donate *~*
Not a mental health professional of any kind
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kimmie11
Regular Member


Date Joined Nov 2008
Total Posts : 24
   Posted 1/30/2009 1:04 AM (GMT -6)   
Hello everyone,
For those having side effects, hope you feel better soon. I have been taking prilosec and a few months ago starting experiencing joint pain and muscle aches. After reading on one of the threads here about it, I decided to wean myself. I have been taking 10mg of prilosec a day instead of the full dose for the last two weeks. I am under the surpervision of my doctor and hope to start skipping every other day in a week or so. I did try to quit cold turkey last year, and the rebound acid reflux was so intense I went back on the prilosec after being off it for three to four weeks. One thing I did notice is routine. I have to eat at the same time every day to avoid having gas pain/bubbling, I eat smaller meals and watch what I eat. I also eat a healthy snack in-between. If I eat too heavy I feel it and if I don't eat I feel it. If you are trying to come off it just be careful and listen to your body. Keep track of what you are eating so you can idenitify triggers, foods that set your acid reflux off, and avoid those foods. Good luck and have a good weekend.
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