allergic with negative skin prick test

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fluffyorganogirl
New Member


Date Joined Oct 2009
Total Posts : 3
   Posted 10/16/2009 8:26 PM (GMT -7)   
 
I have had seasonal and indoor allergies for a long time. I take Claratin and that is usually enough to keep me comfortable.  I have had some additional problems that I need to address so I went to an allergist. He did the skin prick test  (on my back-ouch!). The histamine was positive but all others were negative. This is the second time I have had them done (the first on my arms) and the last time was negative also. I have typical reactions with watery eyes, runny nose, crazy itching on the roof of my mouth, ears and nose, etc.  Again, the claratin really helps prevent this. If I had no allergy or it was just an irratant I don't think that the claratin would make a differance.
 
I have spent quite a bit of time online the last few days trying to find out why this could be. The test appears to be pretty accurate according to most of the information that I have found, and the problems relate more to false positives than negatives. The only other information I find is that "rarely someone tests negative that actually has an allergy". OK-so I am in the minority, but what does that mean? They never explain why this could be, or what that means.
 
I was wondering if anyone else has had a negative skin test even though they knew they were allergic? Do you know why, and what have you done about it?
 
Thank you for any help you can provide.

jujub
Forum Moderator


Date Joined Mar 2003
Total Posts : 10392
   Posted 10/16/2009 9:58 PM (GMT -7)   
I've had the same experience, and I've heard others say they have too. My allergist calls it "non-IGE mediated allergies." Apparently it's a different part of the immune system driving this sort of "allergy." They do respond to antihistamines such as Clariten (I take Zyrtec) but do not respond to desentization treatments.

Apparently those of us who have autoimmune diseases are more likely to have this condition also.
Judy
Co-moderator, Ulcerative Colitis
 
Diagnosed in 2001, finally in remission since March 2006.
Mesalamine is not my friend and steroids are from the devil. Remicade has been my miracle drug.


Razzle
Veteran Member


Date Joined Aug 2007
Total Posts : 4392
   Posted 10/17/2009 4:54 AM (GMT -7)   
If you were taking Claritin, Zyrtec or Allegra within a month of getting tested, the results could have been inaccurate.  Also, allergy test serums are not standardized, so it is possible to test negative because the dilution of the test serums used may have been too low for your body to mount a response to it.  Also, it is known that sometimes the test serums become so old that the proteins that are in the serums break down and are no longer accurate for allergy testing.  You might consider asking for a CAP-RAST blood test, which is not usually affected by antihistamines.
 
Yes, there are other types of reactions to pollens, etc.  Type 4 reactions are the IgG reactions.  Then there are Type 2 and Type 3 reactions, too - these are not as well-understood. 
 
One thing to possibly consider is consulting a Naturopathic physician and asking for Alcat testing for inhalants (pollen, dust, animal dander, etc.) and foods.  Alcat tests look for all types of reactivity, not just Type 1 (IgE-mediated, or "classic" allergies). 
 
Sometimes foods can be cross-reactive with pollens, so you may not be allergic enough to show a reaction on a test for pollens, but when you eat the food that cross reacts during the pollen season, it is like a double whammy and thus you get symptoms.
 
Another possible test method to look into is NAET (www.naet.com) - I have no financial affiliation with this website or company.  It is an acupuncture based allergy testing and treatment method that has a pretty good success rate (about 80%), even with non-IgE allergies.
 
Good luck,
-Razzle
Chronic Lyme Disease, Chronic Bartonella (clinical dx only), Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication/Chemical Allergies & Intolerances, Asthma, Gut issues (dysmotility, non-specific inflammation), UCTD ("Secondary Lupus-Like Syndrome"), Osteoporosis, chronic Lymphopenia, etc.; G-Tube; Currently trying to wean off TPN.
Meds:  Pulmicort, IV Ceftazidime, Heparin (to flush PICC line), Claritin, Domperidone, Colloidal Silver (used topically), probiotics, Milk Thistle, homeopathy.


Chartreux
Veteran Member


Date Joined Aug 2006
Total Posts : 9622
   Posted 10/17/2009 7:37 AM (GMT 0)   
Don't give up a negative allergy testing does not mean you don't have allergies...
There are other testing but do you want to do them???
and Razzle said it pretty good...
but another thing I'd point out is could be a perfume allergy and they can't tests you for everything
that's out there...most of what they did test you for was common allergy, like molds, weeds, tree, cats, dogs..
just try to stay on top of it...
good luck to you and lots of soft hugz
(((((((((((((((((((((((((((((((((((fluffyorganogirl)))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))
I've been tested a total of 3 times two positive testing one was completely negative....
**********************************************
* Asthma, Allergies, Osteoarthritis, Spinal Stenosis, Degenative Disc, Fibromyalgia, Gerd,
Enlarged Pituitary Gland, Sjogren's and Ocular Migraines

********>^..^<********>^..^<********>^..^<********


couchtater
Elite Member


Date Joined Jul 2009
Total Posts : 14414
   Posted 10/17/2009 11:06 AM (GMT -7)   
I was tested four years ago and they found out I was allergic to everything they tested except a beech tree. They gave me a list of things to try to avoid. I was tested on my entire back and had 4 shots, too. I itched for days.
Since then I've becomed allergic to all antibiotics, but there's one that I haven't had it yet (fingers crossed). I've also developed a shellfish allergy. I tried the allergy shots, but was allergic to them!

Oh, such is life....

Joy
Health problems: sleep apnea, hypothyroidism, GERD, glaucoma, OA, environmental, food, and drug allergies, asthma, high cholesterol, pre-diabetic
Medications:Nexium 2X a day, 300mg Zantac, K-Dur, Lasix 2X a day, Zyrtec, Zocor, Lumigan, fish oil, B12, Substex, calcium + D, Advair, Albuteral, nebulizer
 
I don't suffer from insanity, I enjoy every minute of it!
 
 


fluffyorganogirl
New Member


Date Joined Oct 2009
Total Posts : 3
   Posted 10/17/2009 12:23 PM (GMT -7)   

Thank you VERY much for your responses. This is really just a small part of my trying to get a better handle on what is going on with my body.

I have had allergies (dust/mold/pollen) that have been getting progressively worst over the years. They do respond well to Claratin though and they are not really a problem.  So, I don't really care about "testing positive" because I know a lot of what my allergy triggers are. It is just really madening that I test negative, and not understanding why this is.  

I got tested again because the allergist wanted to test me because of the other issues I am having. I went to the allergist because I have I have also had problems with reactions to chemicals and that has been getting much worst. This is the problem.  I have had this problem for a very long time, to different degrees depending on my environment. My reactions are getting worst though and it is interfearing with my breathing. It always made me feel like garbage, but I could deal with that. I have done all I can to avoid things that are triggers and that makes a huge differnce in my life. It is also all I have ever felt like I can do. But now I feel like someone is sitting on my chest and it is freaking me out which does not make the situation better at all...

So, I claim to have a bad reaction to chemicals (according to my allergist) and allergies even though I am negative (which is REALLY unusual). Oh, and when I react I get tingling in my lips and tongue. Online I finally found a few places where this is listed as a symptom of perfume allergy, but everyone I have ever seen has said it doen't make any sence. One said I was hyperventalating. I often get this feeling way before I can smell anything though so that does not explain it. It makes me sound like a hypocondriac and I am not. I am just trying to figure out what is going on with my body and try to live a normal life which is really hard when you can't be around any normal household cleaners, fabric softeners, perfume... etc.

I have never really looked into this online until the last few days and it has been awsome to just read some of what is going on with me is happening to others also. To talk to my doctors I am the only one ever. It really has made me wonder on some of my lower days. I now know that I have multiple chemical sensitivity-just a name, but something that other people deal with also. My main concern is why do I feel like I can't breath. I don't have asthma according to the allergist. So, how can I get help if it gets bad if I & the doctors don't understand what is wrong. This is why I came online to see if there was someone "out there" who also was dealing with these problems and could help to understand why this is happening.

Thank you all for listening-it is just such a relief to find someone who can understand.


Razzle
Veteran Member


Date Joined Aug 2007
Total Posts : 4392
   Posted 10/18/2009 5:28 AM (GMT -7)   
You might want to look into methylation cycle genetic variant testing, and start getting supplemental Vitamin B12 to help support the methylation cycle. Multiple Chemical Sensitivities (MCS) can sometimes be caused by inadequate enzyme function in the liver and mitochondria, which may explain why you feel as if you have Asthma even though tests are negative for Asthma. Also, magnesium is involved in over 300 enzymes in the body (some of which are in the methylation cycle), and the typical Western diet is woefully deficient in magnesium. Other vitamin and mineral deficiencies or imbalances may also be contributing to your situation.

I'd also suggest considering eating as much organic as possible to avoid genetically engineered (GE) foods. GE foods have been strongly correlated with an increase in the development of and severity of allergic reactions to the GE foods themselves as well as new allergies to other substances.

NAET treatment and nutritional compensation for methylation cycle gene variants (i.e., NutriGenomics) may reduce some of your chemical sensitivities. I'm not saying this to give false hope - I have significantly reduced my own sulfite sensitivity through supplementation with Vitamin B12 and other nutrients, and I know of others who have had some success with nutritonal supplements and herbs for their own chemical sensitivities.

Here is one link to get you started understanding about methylation and how it can impact your health (I have no financial connection with this website, clinic, or any of the practitioners):

http://heartfixer.com/AMRI-Nutrigenomics.htm

To get your methylation cycle genetic expressions tested, Dr. Amy Yasko's website offers the same test for half the cost:

http://www.holisticheal.com/health-tests/nutrigenomic-testing/comprehensive-methylation-panel-with-methylation-pathway-analysis.html

Another thing to consider is getting tested for Lyme Disease and related coinfections by a Lyme-knowledgeable physician. Lyme and other chronic infections have been known to trigger the development of and/or increase the severity of allergic and other immune reactivity to a wide variety of things (food, chemicals, inhalants, pollen, etc.). To find a lyme-knowledgeable physician in your area, post a message to the Lyme forum here at HealingWell.

I hope this helps...good luck,
-Razzle
Chronic Lyme Disease, Chronic Bartonella (clinical dx only), Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication/Chemical Allergies & Intolerances, Asthma, Gut issues (dysmotility, non-specific inflammation), UCTD ("Secondary Lupus-Like Syndrome"), Osteoporosis, chronic Lymphopenia, etc.; G-Tube; Currently trying to wean off TPN.
Meds:  Pulmicort, IV Ceftazidime, Heparin (to flush PICC line), Claritin, Domperidone, Colloidal Silver (used topically), probiotics, Milk Thistle, homeopathy.


couchtater
Elite Member


Date Joined Jul 2009
Total Posts : 14414
   Posted 10/18/2009 3:37 PM (GMT -7)   
fog, I have almost the same reactions around certain things. I don't go near the detergent aisle in stores because my mouth and nose itch and I start coughing. Anyone who has been near cigarette smoke makes me sneeze and turn red. Same for perfumes.

It's very annoying isn't it?

Joy
Health problems: sleep apnea, hypothyroidism, GERD, glaucoma, OA, environmental, food, and drug allergies, asthma, high cholesterol, pre-diabetic
Medications:Nexium 2X a day, 300mg Zantac, K-Dur, Lasix 2X a day, Zyrtec, Zocor, Lumigan, fish oil, B12, Substex, calcium + D, Advair, Albuteral, nebulizer
 
I don't suffer from insanity, I enjoy every minute of it!
 
 


fluffyorganogirl
New Member


Date Joined Oct 2009
Total Posts : 3
   Posted 10/18/2009 4:52 PM (GMT -7)   

 

Thanks for the great info Razzle. I have another medical issue that could be causing my liver to not function well, although I do keep up with bloodwork for liver function. I will look into this. I also just recently found out that my Mom (has) and grandmother (had)  B12 deficiencies. I will do some research on these things and talk to my Dr. My primary Dr. is actually pretty good and has been willing to work with me on my unusual problems.

I have had Lyme disease several times, however I seem to be fine after the antibiotics.  I never tested positive. My husband doesn't test positive either but there is no doubt that he has it because we have a picture of an actual spirokete from his blood. He has not recovered completely from the disease.

Peace-Cathryn

 


Post Edited (fluffyorganogirl) : 10/18/2009 6:12:18 PM (GMT-6)

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