Welcome to healingwell you have found a great support group. Sorry to hear you have had so much to deal with and hope your radiation and chemo have been successful. I am not surprised you are feeling depressed and anxious with what you have had to deal with, the Zoloft should help to improve your anxiety and depression but can take a few weeks before you notice any effect (6-8 weeks). Keep posting here and you will get a lot of support and meet people how can relate to what you are going through with your anxiety. You are part of the HW family now and we can help you through this rough time.