Doxycycline causing anxiety/depression?

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mcs699
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Date Joined Jan 2011
Total Posts : 7
   Posted 1/12/2011 4:23 PM (GMT -6)   
I posted this in the depression forum but since it involves anxiety I'm adding it here too.

I am a 23 year old male I recently was sick for about a week with chest infection/flu like symptoms. I went to the doctor and was prescribed doxycyline 100mg two a day. The day I began the medicine within 2-3 hours of the dose I began to experience a loss of interest in everything and corresponding anxiety. At the time I did not tie this with the medicine and assumed it was from being sick at home for a week. The depression and anxiety quickly increased with complete loss of appetite which has never happened for me before until by day 5 began to enter my mind. This is something that is completely out of the ordinary I love my life and friends and family and have no reason whatsoever to have thoughts like this.

I went to see a psychiatrist who basically told me to wait it out. Because it was so sudden, she said it could have been some kind of drug interaction/ side effect which is what I had already thought since I have no reason to be depressed especially so suddenly. Later that day I looked up doxycycline and depression on the web and found quite a few stories that fit mine and I then realized how the symptoms corresponded perfectly with the doxy. I didn't take my dose that night and immediately thought I started feeling better and I ate half a pizza that night!

But now it is the middle of day two and although the symptoms seem to have decreased alot I am still having alot of anxiety and haven't regained my happiness. The last week has easily been the worst of my life and I continually worry that it isn't going to get better. I've found a few stories on this site about the same issues but I was wondering if anyone here has similar experiences and if anyone could provide some insight on how long this might take me to get over? This is incredibly debilitating and I don't want to feel hopeless anymore!

Post Edited By Moderator (stkitt) : 1/12/2011 4:20:58 PM (GMT-7)


stkitt
Forum Moderator


Date Joined Apr 2007
Total Posts : 32602
   Posted 1/12/2011 6:29 PM (GMT -6)   
Hello and welcome to HealingWell,
 
I am sorry for the edit but discussions of suicide are not allowed in the forums.
 
Doxycycline can  cause  agitation or restlessness, anxiety, depression, and mood changes from what I know re this medication. Reference: University of Oxford/CDC
 
Please call your prescribing physician to see if you need to continue this type of medication and perhaps another med would be ordered for you. 
 
I had an allergic reaction to a medication which my Dr. felt would not cause my problem and I was instructed to continue taking it.  2 more days and increase in the  allergic reaction put me in the ER.  Be your own best advocate.
 
Take care and good luck.
Kitt

~~Kitt~~
Moderator: Anxiety, Osteoarthritis,
GERD/Heartburn and Heart/Cardiovascular Disease.

www.healingwell.com

"Life is not about waiting for the storms to pass...
It's about learning how to dance in the rain."~ Vivian Greene

Post Edited (stkitt) : 4/30/2012 8:55:05 AM (GMT-6)


mcs699
New Member


Date Joined Jan 2011
Total Posts : 7
   Posted 1/12/2011 6:42 PM (GMT -6)   
Somebody said...
Doxycycline can cause agitation or restlessness, anxiety, depression, and mood changes from what I know re this medication.


Do you have some kind of documentation of this or is this just from experience and stories? Because I know that it doesn't list depression or anxiety as symptoms on the package but I have read quite a few stories on the web.

nellebutter
Regular Member


Date Joined Apr 2009
Total Posts : 292
   Posted 1/12/2011 7:01 PM (GMT -6)   
Wow Kitt I had no idea doxycycline could do this and ive taken it last year as a precaution after a procedure and I cant recall if it caused a spike in my anxiety...it was exactly a year ago today as a matter of fact.

Mcs I would definitely talk to my doc about any alternative My doc gave me a med recently that made me feel weird and I bugged her until she gave me something that I had already taken before. I agree with Kitt you must be your best own advocate.
"The anxiety the sane and the insane rivalry
Paranoias brought me to my knees
Lord please please please
Take away my anxiety"

"Anxiety" by Black Eye Peas

mcs699
New Member


Date Joined Jan 2011
Total Posts : 7
   Posted 1/13/2011 2:48 PM (GMT -6)   
Please does anyone have a response to this I am really having trouble I've lost all hope and interest in life. It seems as if it's getting worse and all triggered by a stupid antibiotic! I just don't know what to do anymore. I walk around with knots in my stomach all day and I have nothing that I look forward to anymore.

I've got an appointment with my doctor tomorrow but I don't know what to do if this doesn't get better soon...

Mike619er
Regular Member


Date Joined Nov 2009
Total Posts : 429
   Posted 1/13/2011 5:08 PM (GMT -6)   
Hey MCS, I was absolutely shocked when I just looked at the forums and read your post. I just started taking doxycline or however u spell it last week as well. I took it because the doc said supposedly I had the flu like a week earlier lol.

Now I've been sick for the last 3-4 weeks and have been avoiding going to the doc so its kind of hard for me to exactly pinpoint exactly if it had an effect, but reading your post is making me think that it definetly increased my anxiety. I'm on 50 mg of zoloft a day and honestly the first 2-3 days that I was on this medication was ridiculous. At work I couldn't concentrate, I was completely zoning out and couldn't even do simple tasks. I was just sitting there with absolutely no interest in anything....I thought it was just my anxiety getting worse and never thought to think it could be a reaction to the antibiotic.

I'm no doctor and I haven't read up on the symptoms of taking an antidepressent with the antibiotic, I can just speak from my experience in the last week. Know that you're not alone and that I too was having serious problems the last few days. I don't like going into detail into exactly how bad my anxiety got, but just know that I too was having thoughts that were the same way. Not caring or even acknowledging friends, family, etc for the last week or so. It got pretty bad....but today was a decent day and saturday will be my last day taking the antibiotic so I look foward to being able to get off of it and see how I feel then. I'll keep you posted to how it goes

mcs699
New Member


Date Joined Jan 2011
Total Posts : 7
   Posted 1/13/2011 7:28 PM (GMT -6)   
Thanks for sharing the experience Mike. I don't mean to start unfounded rumors or anything but all I know is the day I started doxycycline, within 2-3 hours I was in a spiral of severe depression and anxiety. While on the medicine I had extreme feelings of being in a nightmare and almost a loss of reality. When I stopped the medicine after 5 days this feeling went away within 12 hours.

Now I am still left with this depression and anxiety. I believe the medicine triggered these problems since my family has a slight history of these mental problems. Right now I am just trying to bear each day and get through the couple of what I guess are sort of panic/depression attacks where I feel an overwhelming hopelessness.

If it doesn't get better soon I'm afraid I'm going to have to resort to more medicine. Which is scary since I feel "medicine" is what brought this on in the first place.

Mike619er
Regular Member


Date Joined Nov 2009
Total Posts : 429
   Posted 1/18/2011 9:00 PM (GMT -6)   
Just wanted to bump this back up to the top and let mcs know how I was doin after I'm off the antibiotic.....much better. I don't know if it was from the antibiotic or not, but I'm 100% better then I was when I was on it. I could barely function at work and focusing was downright impossible. It was really wild, it could have just been a bad week for me because I was sick too so I'm not going to blame Doxycycline totally, but I deifnetly don't want to take it ever again. Thank god the flu/cold is gone and hopefully it stays that way

AccidentalAdventurer
New Member


Date Joined Sep 2011
Total Posts : 2
   Posted 9/19/2011 8:13 PM (GMT -6)   
I can 100% identify with the OP, as well as others here posting about sudden-onset anxiety and depression from Doxycycline use. I was prescribed it for mild acne, and within about a week and a half started feeling stranger and stranger. I should have know that something was wrong with this stuff for me, when on the 3rd day of taking it on and empty stomach in the morning, I puked my guts out in the shower - dry heaves for 5+ minutes, even.

Anyway, the first weekend I just felt "off," and it was a mild weekend for me with a light-duty camping trip with the GF. But as the week went on, my memory got shorter and I could not stop surfing websites at work - very OCD-like behaviour, etc. I also could NOT leave my acne alone, even though it was already starting to improve. And then this weekend, at a competitive event where I am usually an excellent master, I could not remember the course or course subtleties and would get lost over sections that I thought I had just memorized a few minutes earlier. Very strange, very surreal...

And lastly, this morning I took just the Doxy alone again and started to get really anxious and weepy. reflecting on the past week, I had been that way too but I am prone to a little bit of overworrying, so I thing I was just writing the emotions off as that tendency. So, on a whim, I google "doxycycline anxiety" this morning and find account after account of people who have landed in the same circumstance.

So a little more looking around and I find that they because Doxy works to antagonize serotonin 1A receptors, they have used it in mice to create mice that are very prone to "anxious-like" behaviours after developing their brains in the presence of a shortage of unblocked HT1A receptors:

Serotonin1A receptor acts during
development to establish normal
anxiety-like behaviour in the adult
phy.ucsf.edu/~houde/coleman/gross.pdf

AccidentalAdventurer
New Member


Date Joined Sep 2011
Total Posts : 2
   Posted 9/19/2011 8:20 PM (GMT -6)   
Oops...hit the -per-post limit...continued here:

And, this is backed up by all sorts of other studies that confirm that the HT1A receptor plays a critical role in stressful situation behavior, etc.:


5-HT1A autoreceptor levels determine vulnerability to stress and
response to antidepressants
www.ncbi.nlm.nih.gov/pmc/articles/PMC2941196/pdf/nihms223457.pdf



So clearly a subset of us are super-sensitive to doxycycline, because it both tampers with the HT1A receptors in our already sensitive(by genetics, or early life exposure/experiences) brains as well as disrupts the flora of the digestive tracet(which is known to have a very high serotonin fraction).


Definitely some nasty stuff for the wrong person. Once my anxiety calmed a bit today, I started drinking lots of water and also got some good, intense exercise and it seems to have taken the edge off. I can only find one source(wikipedia) that notes the half-life of Doxy at 18-22 hours, so as much as I accumulated, it will take a while to even get back to zero - assuming it hasn't made any sort of permanent changes of sorts. Most other reports I read of people with similar reactions say they don't "feel" normal for weeks, if not a month or more, often. But, they often took it for longer than I have.

I wish you all luck, and have made a comprehensive report to my medical professional in hopes that this gets filtered up through the medical community as a potential side-effect of this obviously well-intended medication.

SmurfyShadow
Veteran Member


Date Joined Dec 2008
Total Posts : 2386
   Posted 9/20/2011 4:00 AM (GMT -6)   
*hopes skiitttt dont slap my arms*

Many antibiotics have the side effects of depression, including some depression and migraine medications. Now Skitt, dont go slapping me, this is on personal experience... I was a cutter but I'm cured now! This makes me thankful that I can so far only take 4 antibiotics with no allergic reaction. Doxy gave me hives so I guess Im lucky.

I find a great resource for medications, including cross checking all medications I am on at www drugs dot com (the spaces and spelling was to keep the bots out) man I love the drugs site though! I look up any new medication and check it against my others before I take it there. It has even saved my tush a few times when doctors made mistakes (everyones human)

*gets off skitts lap now and hides back int he corners*
"The Walking Medical Mystery"

Too many Allergies / Too many RXs & DXs

A Rare Gem for Doctors and Guinee Pig
~Medical Caregiver and Doctors Worse Nightmare~

sashagrace
New Member


Date Joined Apr 2012
Total Posts : 2
   Posted 4/16/2012 11:07 AM (GMT -6)   
My daughter is almost 17 and has been on doxycycline for several months now. She is perscribed 100mg in am and 100mg in pm. It has helped the acne quite a bit.

The past 2 months she has been extremely down in the dumps with complaints of hopelessness and not being able to focus. We were thinking it is the tremendous academic pressure she's under during this stressful Jr. year. Also,she has been taking the ACT and SAT tests. Last night, she was crying and saying she feels like a failure and has no drive. Before I booked her an appointment, I decided to investigate if it could possibly be the medication and was completely shocked with what I've been reading on here about the correlation between depression and doxycycline. I am taking her off tonight, and have a call into the dermatologist. I also am taking her to her pediatrician tomm. My biggest concern now is how long these feelings may take to go away once off the medicine.

I am so worried about her and want her to be back to her fun-loving self.... this is heartbreaking.

Scaredy Cat
Forum Moderator


Date Joined Sep 2006
Total Posts : 14056
   Posted 4/16/2012 11:32 AM (GMT -6)   
Hello and welcome.

I am so sorry to hear about your daughter's troubles and feelings of depression. It is frustrating when you get undesirable side effects from a medication that you need! Know however that you are doing the right thing in taking her in for a consult with her doctor.

I am sure that he/she will be able to answer your questions/concerns and help you at this appointment...and that together you will be able to come to a better solution for her.

I wish you the best, and invite you to post anytime with us.

Best of luck,

S.C.
Moderator:Anxiety/Panic

"Courage is not the abscence of fear, it is feeling afraid and doing it anyway!"

"It is when we are most lost that we sometimes find our truest friends"

Panic Syndrome recovery due to CBT

bioluminessence2
New Member


Date Joined Apr 2012
Total Posts : 2
   Posted 4/28/2012 2:36 AM (GMT -6)   
I began taking Doxycycline when I was 21 years old for acne/ rosacea. It was around this time that I also developed generalized and social anxiety. At the time I had no idea what was going on. I honestly thought that I was going crazy because I had never felt that way before. I did review the side effects with the doctor and I was concerned about side effects but was basically informed that the most I would suffer would be a stomache ache. Anxiety was not listed as a side effect and to be honest I didn't really understand what I was experiencing - I wouldn't even know to label it as anxiety. I took the Doxycycline for three years and it did clear up my acne. Although my symptoms have improved with therapy I still suffer from anxiety 13 years later. I always wondered whether Doxycycline was the culprit and triggered the anxiety because my symptoms began around the same time I started the medication but really I always attributed the anxiety to genetics plus personal issues and things going on at the time of the onset of symptoms. Three years ago I revisited the issue because I had a severe skin flare up and my doctor prescribed Doxycycline. My anxiety went into overdrive - I hadn't experienced anxiety like that since my symptoms first began. I went off the medication immediately and began to feel better right away. A previous reply stated that some of us are by way of genetics especially sensitive to this medication and are predisposed to anxiety if we take it. I believe this is true of me - I had always felt a bit anxious in certain social situations and was prone to worry and some obsessive thinking in my teens. However, it was never debilitating and I was able to enjoy life. The anxiety that I suffer with has been extremily debilitating. I've tried talk therapy (CBT), Zoloft, meditation classes and even acupuncture and while I've improved my brain is just not the same. I hate thinking that it's all because of a anti-biotic that I took to get rid of some acne but the more posts that I read the more I'm coming to the realization that this is the culprit or at least a major factor in my development of this disorder. I think that it triggered the anxiety (something that I was maybe genetically prone to) and because I took it for so long it set changes in motion in my brain (basically killed my ability to produce serotonin and caused me to develop negative patterns of thought) that seem to be irreversable to some extent. Is that kind of damage possible if one takes it for 3 years? To all of you who only took it for a month or two I think that you'll be able to recover from this. I wish I had stop taking it much much sooner. As for me I am looking into taking legal action. Based on my own experiences and that of others the risks need to be investigated and listed on the list of side effects. If I had known that this medication would effect anything having to do with the brain (besides a common headache as is listed as one of the side effects now) I would have never taken it. Best of luck to all of you.

Bereft
New Member


Date Joined Jul 2011
Total Posts : 2
   Posted 5/9/2012 3:29 AM (GMT -6)   
There has been a petition started for a warning for those taking doxycycline. Many have suffered anxiety, depression, hallucination and suicidal thoughts while on this drug. Please sign this petition in the hope we can save a life. (The woman who started it has lost a son, as have I, to this medication.)
 
I am very sorry,  however, these petitions are not allowed in the forums as per rule #4

Post Edited By Moderator (Scaredy Cat) : 5/9/2012 8:22:29 AM (GMT-6)


Scaredy Cat
Forum Moderator


Date Joined Sep 2006
Total Posts : 14056
   Posted 5/9/2012 9:28 AM (GMT -6)   
Bereft,

I am so sorry to hear of your loss. That is a devastating story...(I looked it up as posted in the depression forum)

I wish you the best in continuing to get the word out regarding this drug and the possible negative side-effects it can have.

You may post your experience and opinions, but we can't have petitions here, as this is a peer support group, and as such, carries no polictical agenda. (please see rules)

You are otherwise welcomed and encouraged to post anytime.

Scaredy Cat
Moderator:Anxiety/Panic

"Courage is not the abscence of fear, it is feeling afraid and doing it anyway!"

"It is when we are most lost that we sometimes find our truest friends"

Panic Syndrome recovery due to CBT

try&think
New Member


Date Joined Jun 2012
Total Posts : 1
   Posted 6/15/2012 4:42 PM (GMT -6)   
Thanks, everyone, for sharing your experiences. Thank God for sites like this since there's no other way to get this fairly "new" information.

I have been on doxy for one week to treat an infected cut on my hand. Fortunately the infection has cleared and this is my last scheduled day for doxy. Have been feeling distracted and down but blamed that on being upset about the injury and not exercising, and having been depressed in the past, and having a lot of stressful things going on. But today it was so bad I really felt I cannot go on like this, or at all -- and that was such an extreme feeling I wondered finally if the doxy was the culprit. Googling "doxycycline depression" brought me here. Aha. There is a possible explanation and reason for hope!

Today may have been particularly horrible because I forgot to take the probiotic "pearls" (coated so the little critters get all the way into your gut where they belong) to counteract the antibiotic's tendency to kill off all your good bacteria. I made the connection reading Accidental Adventurer's brilliant post, above, where he notes that your good digestive bacteria help with serotonin balance and mood and doxy wipes them out when it goes after the bad guys. So I just popped a "pearl" (available at drugstore and terrific at keeping your tummy happy while on antibiotics) and hope that will help some.

For folks who are taking doxy for acne -- as a 13-year acne victim I sympathize. I finally got rid of it by using Oxy-10 (a strong benzoyl peroxide solution) 3 times a day after gently washing and exfoliating with Buff-Puff. I did this on half my face to see if it got better than the other half. (I was desperate, and am very analytical.) It worked. The treated side of the face was very red and angry but then cleared up, so I started doing my whole face. Problem permanently solved. You may not be one of the people that heavy-duty benzoyl treatments help, but if you have not given it a serious try, it seems better than flooding your whole body with antibiotics. Especially since we may all need these strong antibiotics someday for something life-threatening and there's a risk they will stop working (germs will get too "smart" for them) if they are too commonly used. But if it's the only thing that works, never mind -- acne is horrible too. I took tetracycline for a few years trying to get rid of it -- it only worked partially and now I wonder if it exacerbated my tendency to depression.

Thanks again, all.

irret
New Member


Date Joined Aug 2012
Total Posts : 2
   Posted 8/15/2012 9:10 AM (GMT -6)   
doxycline - our 13 year old confident and happy son started taking it for acne 3 weeks ago. the past 2 weeks he seemed quieter than normal, had several violent nightmares , then started being teary and feeling hopeless and no confidence. My husband and I were devastated at seeing him like this. Trying to work out what couold possibly be causing it. then i realized he had been taking antibiotics for about the same time and i googled doxycline and depression and there it was. We have absolutely no doubt this caused our sons sudden decline. We stopped it immediately and now 4 days later, can see him improving. It has given us such a fright that a simple antiobiotic can cause such damage.  

Denominator
New Member


Date Joined Aug 2012
Total Posts : 6
   Posted 8/25/2012 10:58 PM (GMT -6)   
I have been on doxycycline and that stuff is poisonous and dangerous. There are petitions out there to get the stuff banned and I wholeheartedly signed the petition and do not recommend it for anybody.
Panic attacks (beaten after twelve or so years) GAD and hypochondria

luckydog1977
Regular Member


Date Joined Aug 2012
Total Posts : 121
   Posted 8/26/2012 8:41 AM (GMT -6)   
I had a staph infection on my leg. After 35 days on 3 different antibiotics my doctor finally biopsied the wound which was large deep and disgusting. It was MRSA....just lovely. I'm allergic to cipro, levaquin and all their cousins....so she gave me doxycycline. It knocked out the infection...finally. I was on meds for 45 days. Doxycycline 500mg 3x a day....I was anxious and depressed but I don't know if it was situational from what I had been through or the medicine. Thank goodness its over tho I have a terrible scar to remind me.
GAD, panic disorder, bipolar1, GERD migraine with aura, hemiplegic migraine, prolonged q t interval, tachycardia, arrhythmia, fibromyalgia, polycystic ovarian disease, PTSD

Klonopin, Cymbalta, Abilify, Eskalith,Lyrica, Flexeril, TalwinNX, Prilosec, Verapamil, Toprol XL, Synthroid, Lipitor, Phenergan, Melatonin, Multivitamin, B12, b complex, vitamin c, magnesium, vitamin d (50,000iu's prescribed)

Helpless28
New Member


Date Joined Mar 2012
Total Posts : 19
   Posted 8/27/2012 3:58 AM (GMT -6)   
I am taking this drug now for UTI and noticed I am very restless tonight. I have anxiety pretty bad and wouldnt have took it if I'd known.

Nina0210
New Member


Date Joined Jun 2013
Total Posts : 1
   Posted 6/18/2013 4:31 PM (GMT -6)   
I am posting on here because I have used doxocylcin for only 6 days following a sinus infection that ive now had for almost 2 weeks. from personal experience I can say I will never use this again and am now on amoxicillin.

These tablets caused me to feel:
very anxious, like i was in a constant nightmare and felt scared and worried constantly,dizziness like the room was spinning,and had no interest in anything. I finally spoke to my mum who read these comments below and that's when we realised it was the tablets that was making me feel like this.

I just want to feel how I did before, and it should take up to 48 hours to get out my system, but my doctor will speak on Thursday to me to see.

Usually a positive person and laid back but these tablets made me feel the lowest I've ever felt in my whole life and have never cried as much!! :s

Can now say I cannot wait to go to the gym, do light exercise and get it out my system as soon as poss.. :)

Future reference for anyone, do double check before and if you do feel like that then do talk to someone rather than worry.it helps a million.they do finally understand why you feel like that.

Ros82
New Member


Date Joined Dec 2013
Total Posts : 1
   Posted 12/11/2013 2:11 PM (GMT -6)   
I'm posting on here after suffering anxiety attacks. I took Doxycycline for just one week for a chest infection/sinusitis. I've always been a bit of a worrier, but never suffered any anxiety attacks or panic attacks before. This feeling is absolutely horrendous. After the first day, when I had to take 2 tablets, I ended up on the phone to the emergency doctor as I was shaking so much. They thought it was from the infection as this isn't a listed side effect of this drug.

Only after my friend researched for me, did we find that many people on this antibiotic have suffered from the same symptoms as I am.

I've now been off the drug for 48 hours and praying that symptoms will ease. This is the most horrendous thing I have ever had in my life. (I'm 53).

Scaredy Cat
Forum Moderator


Date Joined Sep 2006
Total Posts : 14056
   Posted 12/11/2013 2:29 PM (GMT -6)   
Hi Ros82,

I am sorry to hear of this issue! I think that it is proof...from so many posts here, that what you are experiencing can certainly be a s/e for some people...after taking antibiotics.

Not everyone reacts in the same way...which is why your doctor may not attribute it to your med...

...and certainly, being sick can also bring on anxiety issues and symptoms...

...but to be on the safe side, it was wise to get off of that particular Rx.

I do hope however, that you were given an alternative antibiotic? It is not advised to just stop one altogether...as your infection could actually get partially resistant, come back and be worse.

I hope that you can work this all out with your doctor, that you heal from your illness...and that your anxiety goes and does not return!

Well wishes!!

Scaredy Cat
Moderator:Anxiety/Panic

"Courage is not the abscence of fear, it is feeling afraid and doing it anyway!"

"Worrying does not empty tomorrow of its troubles...it empties today of its strength."
Corrie Ten Boom

Panic Syndrome recovery due to CBT

stkitt
Forum Moderator


Date Joined Apr 2007
Total Posts : 32602
   Posted 12/11/2013 3:20 PM (GMT -6)   
It seems that many people who take Doxycycline have episodes of anxiety.  I have also seen other antibiotics cause anxiety.  You were right to question the antibiotic as the cause of your anxiety.
 
Hopefully your Dr. was able to choose a different antibiotic for you and that you are on the road to recovery.
 
Kindly,
Kitt
~~Kitt~~
Moderator: Anxiety, Osteoarthritis,
GERD/Heartburn and Heart/Cardiovascular Disease.



"She Stood in the Storm & When the Wind Did Not Blow Her Away, She Adjusted Her Sails."
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