Serzone replacement

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Shoeman
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Date Joined Aug 2012
Total Posts : 31
   Posted 8/25/2012 5:42 PM (GMT -6)   
Hello,
After being on serzone for 6 yrs, the generic version of the drug was pulled. Serzone worked great for anxiety. I'm off serzone and working with my doc to find a replacement. So far I've tried trazadone, remeron, and now cymbalta. I'm taking 20 mg at night and am having a tough time sleeping. It has only been day 4. Serzone was a unique drug, so I am worried that I won't be able to find something that reduces anxiety. Tried buspar and Paxil prior to finding serzone. Im fighting thru Cymbalta, does it really work?

Regards

luckydog1977
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Date Joined Aug 2012
Total Posts : 121
   Posted 8/26/2012 8:45 AM (GMT -6)   
I don't think it helps anxiety or insomnia. Maybe you should look at seroquel xr. Take it at night and you'll sleep like a rock and it really helps anxiety.
GAD, panic disorder, bipolar1, GERD migraine with aura, hemiplegic migraine, prolonged q t interval, tachycardia, arrhythmia, fibromyalgia, polycystic ovarian disease, PTSD

Klonopin, Cymbalta, Abilify, Eskalith,Lyrica, Flexeril, TalwinNX, Prilosec, Verapamil, Toprol XL, Synthroid, Lipitor, Phenergan, Melatonin, Multivitamin, B12, b complex, vitamin c, magnesium, vitamin d (50,000iu's prescribed)

luckydog1977
Regular Member


Date Joined Aug 2012
Total Posts : 121
   Posted 8/26/2012 8:47 AM (GMT -6)   
Ps-ive been on cymbalta for two years and I take it in the morning.
GAD, panic disorder, bipolar1, GERD migraine with aura, hemiplegic migraine, prolonged q t interval, tachycardia, arrhythmia, fibromyalgia, polycystic ovarian disease, PTSD

Klonopin, Cymbalta, Abilify, Eskalith,Lyrica, Flexeril, TalwinNX, Prilosec, Verapamil, Toprol XL, Synthroid, Lipitor, Phenergan, Melatonin, Multivitamin, B12, b complex, vitamin c, magnesium, vitamin d (50,000iu's prescribed)

Hibee
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Date Joined Oct 2008
Total Posts : 2273
   Posted 8/26/2012 9:21 AM (GMT -6)   
Hi

Good to meet you and welcome to the forum you will find good support here. I have never taken Cymbalta so can not really comment on weather it works well for anxiety what I do know is that when it come to medication we are all different and what works well for one person may not for an other.

I have found Lyrica to have helped with my anxiety and I also take Seroquel which does help you sleep. Keep posting we are here to support you.

Hibee
I try not to worry about the future -- so I take each day just one anxiety attack at a time.

ANXIETY & PANIC FORUM MODERATOR

Diagnosed with:- Asperger's Syndrome, dyslexia, gad, sad, ocd, depression, reactive arthritis and Scheuermann's Disease (Adult)

Shoeman
Regular Member


Date Joined Aug 2012
Total Posts : 31
   Posted 8/26/2012 9:27 AM (GMT -6)   
I'm not sure that I can handle another day of cymbalta. It makes me jittery and anxious, the exact opposite of what I am trying to accomplish! My doc may insist that I stay on cymbalta for at least 2 weeks to give it a fair try. Good news is that at 20 mg - no sexual side effects. I'm suppose to target 60 mg for GAD, but I don't see me getting to 60 at this pace. I'll mention seroquel, but my family practice doc may not feel comfortable with some of the off label uses. He probably will refer me to a psych doc.

Is Buspar worth a try? Seems kind of lame based on previous posts.

Hibee
Forum Moderator


Date Joined Oct 2008
Total Posts : 2273
   Posted 8/26/2012 9:38 AM (GMT -6)   
Hi

Ask you GP to refer you to a pdoc as they are the specialists when it comes to medication. Have you looked into any kind of therapy? As this along with medication gets good results.

Hibee
I try not to worry about the future -- so I take each day just one anxiety attack at a time.

ANXIETY & PANIC FORUM MODERATOR

Diagnosed with:- Asperger's Syndrome, dyslexia, gad, sad, ocd, depression, reactive arthritis and Scheuermann's Disease (Adult)

Shoeman
Regular Member


Date Joined Aug 2012
Total Posts : 31
   Posted 8/26/2012 12:06 PM (GMT -6)   

Since I was a kid in HS, I remember sitting in class sweating…hoping that the teacher wouldn’t call in me – even though I knew the answer.  I coped through HS, college, and most of my first job.   In my 30’s, I had an anxiety attach while doing a business presentation.  It wasn’t pretty.  Since then I have developed an aversion to presentations and social situations.  I got help from my family doc, who tried the “usual drugs”: Paxil being one.  I use Xanax and Ambien as needed, but I can’t take Xanax every day, so the doc says.  My doc referred me to a psych doc who put me on Remeron, which didn’t work.  I went back to my family doc who put me on Serzone, which worked very well.  Problem is that Serzone was pulled from the market in early 2000.  I was able to get the generic version, but now it is completely gone.  My diagnosis is Panic/Anxiety disorder, no depression.  I simple have a ton of anticipatory anxiety which leads to the classic symptoms: sweating, racing heart, confusion, etc.   Before meds, I tried a variety of herbs, seeing a counselor, keeping a journal, etc.  All of these techniques helped, but I could not overcome the constant fight or flight feeling inside. The constant rush of adrenaline is a bummer.  I am in shape, don’t smoke, drink very little beer, and jog 3x/week.  That’s my story, thanks for listening.


Shoeman
Regular Member


Date Joined Aug 2012
Total Posts : 31
   Posted 8/27/2012 5:18 PM (GMT -6)   
After 5 days on Cymbalta, I'm calling it quits. The side effects are too great for me, even at 20 mgs/day. Right now I am at a loss on which meds to even suggest to my doc, except for seroquel (which was suggested on this site). I've blown thru most of the more common drugs. Seems like I'm not a good candidate for SSRI or SNRI drugs.

Bummer.

Scaredy Cat
Forum Moderator


Date Joined Sep 2006
Total Posts : 14486
   Posted 8/27/2012 6:13 PM (GMT -6)   
I am sorry to hear of your recent trouble. It is so frustrating when something that has helped you cope for so long, isn't available anymore.:(

Remembering back...did you have any side effects when starting the Serzone? Did you say that Nefazodone was not available anymore?

I am not sure if there are any other meds that are considered as mild in the side effect department as Cymbalta...maybe Effexor? It is hard to say, because everyone's make-up is different! I would say though that almost all meds are going to have some kind of initial side effects that you have to weather.:(

I hope that you find the answers that you need soon. Keep posting with us. We care and are here to listen and support.

Scaredy Cat
Moderator:Anxiety/Panic

"Courage is not the abscence of fear, it is feeling afraid and doing it anyway!"

"Worrying does not empty tomorrow of its troubles...it empties today of its strength."
Corrie Ten Boom

Panic Syndrome recovery due to CBT

Shoeman
Regular Member


Date Joined Aug 2012
Total Posts : 31
   Posted 8/28/2012 6:27 PM (GMT -6)   
Serzone was a mild drug in terms of side effects.  The major one being headaches.  I started slow and moved up to a rather high dose.  Now the interesting part: my doc perscribed Seroquel.  I was ready to make the suggestion, but he went there first.  It's cool that Seroquel was mentioned on this board.  First dose is tonight at 25 mg.  I think that I'll break the pill in half to see what it does.  Thanks for the support.

Scaredy Cat
Forum Moderator


Date Joined Sep 2006
Total Posts : 14486
   Posted 8/28/2012 9:15 PM (GMT -6)   
I wish you the best as you start out on the new med! You are smart to start off slow (make sure that it is okay to break this particular med in half) and hopefully avoid unwanted side effects.

Keep us posted, and know that we are pulling for you.:)

S.C.
Moderator:Anxiety/Panic

"Courage is not the abscence of fear, it is feeling afraid and doing it anyway!"

"Worrying does not empty tomorrow of its troubles...it empties today of its strength."
Corrie Ten Boom

Panic Syndrome recovery due to CBT

Shoeman
Regular Member


Date Joined Aug 2012
Total Posts : 31
   Posted 8/30/2012 3:40 PM (GMT -6)   
Update: at 50 mg a day of Seroquel. I take 25 mg at night and 25 mg in the morning. No side effects except being tired, which is good at night! I think 50 mg is a pretty light dose, because I haven't noticed any major anti-anxiety effects right now. It looks like I can take the dosage up to 800 mg/day, if I have too. Does anyone know what dose is effective, given that everyone is different?

Shoeman
Regular Member


Date Joined Aug 2012
Total Posts : 31
   Posted 9/3/2012 6:45 PM (GMT -6)   
I think that I'm ready to crank Seroquel up a notch. Again, no side effects, but so far it is not as effective as Serzone for anxiety, at least not at this dose. I'm going to call the doc tomorrow and see if he'll OK 50 mg 2x/day. Again, if there are any Seroquel users out there, let me know what dosage seems to work for you.

Shoeman
Regular Member


Date Joined Aug 2012
Total Posts : 31
   Posted 9/20/2012 4:46 PM (GMT -6)   
Update: I am now taking 75 mg 2x/day for a total of 150 mg. Great sleep, but it doesn't seem to do too much for anxiety - at least yet. Calling all Seroquel users...is it worth bumping up to 200 a day or is this just not the right drug?

p.s. minimum side effects, mostly sleepy.

frizzbee
Regular Member


Date Joined Sep 2012
Total Posts : 98
   Posted 9/21/2012 6:43 AM (GMT -6)   
shoeman, i haven't heard of seroquel being used for anxiety...i have heard it being used as a mood stabilizer (for bipolar disorder) and an anti-psychotic (for schizophrenia and schizoaffective disorder). i know a lot of doctors will prescribe a lose dose "off label" for sleep because drowsiness is one of its major side effects.

i am taking effexor (regular, not extended release) now...been taking it almost 2 weeks, and i already notice an improvement in my anxiety. my p-doc said it is good for depression and anxiety together. everyone is different, but i wanted to share that i am hopeful it will be the right med for me in case you want to consider it.

i hope you find the right med...i know the hunt can be frustrating!!
dx: dysthymia, generalized anxiety, health anxiety (hypochondriasis)

Shoeman
Regular Member


Date Joined Aug 2012
Total Posts : 31
   Posted 9/23/2012 8:21 PM (GMT -6)   
Thanks for the support. You are right about the hunt being frustrating, and seroquel causing drowsiness. I also get a major stuffy nose after an hour of taking the drug. I'm not sure that the limited benefit that I'm getting in anxiety relief is worth feeling tired all day. I'll do some prelim work on Effexor. As long as it doesn't kill my sex life I'm willing to give it a try.

stkitt
Forum Moderator


Date Joined Apr 2007
Total Posts : 32602
   Posted 9/24/2012 10:57 AM (GMT -6)   
 
Wow, you have been on the BIG one - Remeron  - this is the one that is suppose to pull most people out of the deepest depression.  I have refused to go near this drug as the side effect of severe drowsiness has held me back.  I do well on Trazadone at 150 mg everynight but you do have to give this some time to work and I did not have any side effects from this med as 150 mg is a low dose.
 
I have been on so very  many of these meds for my anxiety and depression and find the Effexor works the best for me.  As with any of the meds, you do have to make it through the side effects of the first 4-6 weeks as well as remember that it takes that long also for the medication to reach it's full therapuetic effect.
 
Good luck,
Kitt
 
 
~~Kitt~~
Moderator: Anxiety, Osteoarthritis,
GERD/Heartburn and Heart/Cardiovascular Disease.



"I am not afraid of storms for I am learning how to sail my ship" ~ Louisa May Alcott

Shoeman
Regular Member


Date Joined Aug 2012
Total Posts : 31
   Posted 9/26/2012 8:52 AM (GMT -6)   
Yes, Remeron, the big gun.  Didn't have any side effects, but it did not help with anxiety either.  I think Remeron confirmed that I don't have any depression, just anxiety.
 
I'm still a little shy about taking another SNRI like Effexor - the sexulal side effects are a bummer, and I'd like to keep my sex life intact :)
 
Thanks for keeping the feedback coming.  The process of finding a Serzone replacement is way more complicated than I thought.  If anyone has any ideas on an anti-anxiety med, let me know.
 
p.s. I'm giving Seroquel a few more weeks and possibly a higher dose spread out over an entire day.

Shoeman
Regular Member


Date Joined Aug 2012
Total Posts : 31
   Posted 9/27/2012 8:01 PM (GMT -6)   
I don't think that I'm going to give Seroquel any more time. At 100 mg in the morning, I felt like a zombie at work. It is great for sleep but doesn't really do much for day to day anxiety. Bummer. I cut my dose in half this evening and will taper off this week. This sucks.

Shoeman
Regular Member


Date Joined Aug 2012
Total Posts : 31
   Posted 9/30/2012 1:12 PM (GMT -6)   
I've tapered off seroquel. I seem to be able to "get off meds" pretty easily compared to others. Now what? I took a .5 Xanax this morning to get thru a church service and .5 ambien for sleep last night. I feel like I am at the end of the line with meds for anxiety, although I might give Effexor XR a try, albeit the sexual side effects might be a show stopper. I'm going to meet with my doc next week, but he is probably as perplexed as me.

Shoeman
Regular Member


Date Joined Aug 2012
Total Posts : 31
   Posted 10/4/2012 3:35 PM (GMT -6)   
New plan: Ativan 1x/day for starters; seroquel at night for sleep. We are dumping the xanax and ambien as needed. This is truely anxiety without depression, so we stopped going down the SSRI and SNRI path for now, although they do work for some people. I feel like I am writing to myself....is anyone out there?

Shoeman
Regular Member


Date Joined Aug 2012
Total Posts : 31
   Posted 10/7/2012 12:44 PM (GMT -6)   
Update: the idea is to stabilize my mood with Seroquel. So far at 50 mg/night, I get the bonus of sleep. 1 mg of Ativan in the morning doen't provide enough help. So, I had the green light to crank it to 2 mg in the morning. We'll see how it goes this first week of work. I have presentations and meetings up the wazoo. No side effects yet, although seroquel does stuff me up for a hour after taking it.

Any Ativan users out there?

Shoeman
Regular Member


Date Joined Aug 2012
Total Posts : 31
   Posted 10/8/2012 7:13 PM (GMT -6)   
Did OK at my big meeting today. Took 3 Ativan at 8 am. I probably should spread this out to 2 in the morning and 1 after lunch. I can certainly function ok with Ativan - not as quick of release as xanax, but lasts longer and I didn't crash after the effects sort of wore off. I hope this is the best path for me. Hard to tell...Benzo's are not particular embraced, yet what's the diffference: on serzone for the rest of my life or a benzo. Seems the benzo is actually safer than what I was taking. Again, any Ativan users out there? I can handle both positive and negative at this stage in my life.

Shoeman
Regular Member


Date Joined Aug 2012
Total Posts : 31
   Posted 10/10/2012 9:13 PM (GMT -6)   
Looks like I've landed on 3 Ativan a day, am, midday, and evening. Now we'll see if my doc renews the script.

It does seem to block anxiety and panic.

Shoeman
Regular Member


Date Joined Aug 2012
Total Posts : 31
   Posted 10/17/2012 4:27 PM (GMT -6)   
For now I'll stop with the updates. By now you are all bored I'm sure. I landed on 50 mg of Seroquel at night for sleep and mood stabilization, plus 1 mg Ativan, 3x/day. Feels like I could use more Ativan during the day though. For now, this is the best thing that I have to fight anxiety - no side effects - at least not yet. Thanks for the encouragement.
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