My anti-depressants are SSRI(s). They don't mix well with the TRIPTAN family of migraine abortives. I don't know if all of the the triptans are incompatible, but I went to see a new neurologist and he prescribed a triptan (even though they don't work on me or make me feel worse than the migraine) that had a major interaction problem with one of my SSRI's. I don't think he even looked at my medication list. I picked up the prescription and did some research on it, and if I had taken it, I probably would have died from cardiac arrest. I would always recommend checking out the compatibilty of medications on your own, because Doctors and Pharmacists can and do miss interaction problems. I keep two different Pill books on hand to research any new medications I am written. Better safe than sorry. My problem now is that the migraine medications that work for me are narcotic in nature, and my regular doctor won't prescribe them now, because one of the other doctors decided I had been taking them too long. Instead of being referred to a "pain clinic" as I was told, I was actually referred to a "detox program" for major, cocaine, crack, and heroin addicts. Boy was I pissed that I was lied to. I tried to get an appointment for two months, but then the Director stopped returning my calls. I guess he figured since I was cut off cold turkey, I had already detoxed and no longer needed an appointment. I'm switching to a new neurologist and pain clinic to try to get my migraines back in check.
Good luck and let us know how things go!