I was on Effexor for awhile and never had any BP problems. The problem I had with it is that it stopped working and if I remember correctly, I was on at least 200mg twice a day. I was on 120mg of Cymbalta until about a month 1/2 or so ago. I liked it at first but then it quit working too. Now I'm on Prozac. So far so good. I think Cymbalta is in the same category as Effexor but I'm not positive. I know that I liked the Cymbalta better that the Effexor though. I wish I could still take it. It does help with aches and pains that go along with my fibromyalgia.
Hope that helps a little.
"God grant me the serenity to accept the things I can not change, the courage to change the things I can and the wisdom to know the difference."
DX: ankylosing spondylitis, periferal neuropathy, chronic migraines/headaches, depression/panic attacks, bi-polar, hypothyroidism, hypoglycemia, sleep apnea
RX: synthroid, estradiol, cymbalta, prozac, geodon, lamictal, inderal la, klonopin, seroquel, imiprimine, aspirin, (relpax, maxalt, phenergan, esgic plus, xanax, PRN for migraine)
Surgeries: hysterectomy 1997, tonsillectomy 2001, deviated septum 2005, cataracts (both eyes) 2006