I took cymbalta for a few months, and actually lost weight...maybe about
5-7 pounds. It totally killed my appetite, so I don't see how I could have gained weight from it. At the beginning, it made me really nauseaus and tired. Then, as my body got used to it, I started to get a lot of "nervous" energy from it. My dr. said we could switch from the 60mg back to the 30mg and that might do the trick, but in the end we decided to go back to zoloft. I was happy with the cymbalta, though, and would go back on it again, if the z doesn't help.