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Posted By : Alexandria2015 - 6/30/2015 7:38 AM
does anyone know what the chances of 1 parent being a carrier of the CF gene and the other parent being negative and whether they will and what the percent number to pass on the children?

Posted By : Gemsi - 6/30/2015 4:47 PM
There is a 1 in 25 chance of someone being a carrier of the CF gene. (uk statistics).

If you look at the full CF gene being part of a puzzle, there are 2 pieces to the puzzle. 1 piece is from each parent.

A carrier of CF has a healthy gene from one parent and a faulty gene from the second parent. A person with CF has a faulty gene from each parent.

IF one parent is a carrier and the other parent is not, then their child won't have CF, but there is a 50-50 chance their child could be a carrier.

IF both parents are carriers, then there is a 1 in 4 chance their child could have CF.

Hope this helps, tried to break it down as much as I can.
Moderator of the Cystic Fibrosis forum

Hey, I'm Gem with CF, age 29 and diagnosed at 2 years old. I'm no expert but having CF myself I've learnt a few things along the way.
Diagnosed with: Cystic Fibrosis, Asthma, ABPA, Clinical Depression, Mild Liver Cirrohsis, Mild Osteopenia, Erythema Nodosum, Proximal Myositis, Polyarthralgia

Posted By : Gemsi - 6/30/2015 4:49 PM
Here is a diagram to make it easier to understand :)
VIEW IMAGE

Posted By : Wiley Coyote - 7/12/2015 6:22 PM
Unless of course, one parents caries an untested for or unidentified CF gene, and then the child could have CF if the other is a carrier. And there is also such a thing as CF -like syndrome where someone only has one identified gene, and so supposedly is a carrier, but has all the issues of CF.
CF DDf508 w/ CFRD (dignosed 3 months) 43 years old, 2 kiddos

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