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Posted By : JHarvey - 1/17/2012 1:18 PM
Can no longer afford brand name Lialda and was wondering if anyone has had any experience with replacing brand name Lialda with generic Mesalamine tablets of the same dose?

Generic Mesalamine 1.2g tablets are a third of the cost with the same active ingredient as in Lialda.

Has anyone gone this route for your drugs and had success with the product.

There is a company in Barbados named Sun Pharma that sells the 1.2g Mesalamine pills at a very good price, Lialda without insurance is just way to expensive at this time.

Or is there other stuff in Lialda that the generic mesalamine doesn't have that will make all the difference in the drug working or not, or is it really just the mesalamine and the dose?

Posted By : AZYooper - 1/17/2012 2:00 PM
The difference between the various drugs is the delivery system and dosage. The generics use the asacol type coating as far as I know. There is a Canadian manufactured generic asacol 400mg that is sold in Canada and I think Sun Pharma's 400mg version is also sold there. Sun Pharma is an Indian company.

I would use a Canadian pharmacy if you are American. They are more reputable but require an RX. Generic mesalamine runs 30-40 cents per 400mg tab. The generics available in the US are sulfaslazine and Colazal which are compounds that break down into mesalamine in the colon. Sulfaslazine is cheap. Generic colazal is pretty expensive. Sulfasalazine causes intolerance problems in 30% of users. I ended up on colazal but I have insurance for generics. If I had no insurance I would use the generic from Canada.

Posted By : DBwithUC - 1/17/2012 2:27 PM
it is the coatings, or chemical bonds, or other things that tme the release to ocur in the colon and not the gut or small intestine that distinguish the name brands. In some cases the ph of the gut is used to cut a chemical bond, or disolve a coating, in one case the bacteria of the colon are used to release the drug.

But the main thing about Lialda is the sponge/matrix aspect of the delivery system that allows for 1x daily dosing. If you did nto hav ethis matrix with this coating, I would take a lower does of generic more times thorught the day. I would not take several 1.2g generic tablets all at once.

Posted By : journey2health - 7/24/2017 3:12 PM
Just picked up my first batch of generic Lialda. $10 for a three month supply. whoopee!

Posted By : DBwithUC - 7/24/2017 4:20 PM
i read about the generic approval. who makes it?
11/08: ischemic colitis and scope perf colon. 12cm colon/ileocecal resected. IV antib:sepsis.
01/10: Dx: Mod. UC pancolitis. Rx: Lialda 3x.
02/11: Major flare w/antib:sinus. Rx: 40mg Pred taper. 6mp.
07/11: Histol remiss rt/trans; worse sigmoid. Rx: Rowasa & hydrocort
---
Curr: 1-2 soft-formed stool, no urgency: Lialda 2x, NO PRED, probiotics, Vit-D/C

Posted By : Celeriac - 7/25/2017 7:29 AM
My pharmacy automatically applies a manufacturer coupon for my Lialda and I pay $10 / month. Might be something to look into/ask about (if you're in the states)

Posted By : iPoop - 7/25/2017 7:49 AM
I would assume generic lialda is made by Zydus Pharmacueticals. These links have details that ypur pharmacy might need to order it.

This is their product page for 1,200mg mesalamine delayed release tablets (aka lialda generic):
www.zydususa.com/product-details/?id=307

This is their product page for 800mg mesalamine delayed release tablets (aka asacol hd generic). My blue cross blue shield insurance didn't count the zydus 800mg tablets as a true generic, insisted it was licensed-by-asacolhd for a significant premium (certainly the pharmacy list price was only $15 less than brandnamed lialda, for this "generic").
www.zydususa.com/product-details/?id=216

Report back if you get these! Cost and effectiveness are good for us all to know. These darn insurance copays are killers, and it'd be great if we could all get an affordable mesalamine-delayed-release tablet as a generic here!
Moderator Ulcerative Colitis
John
, 39, UC Proctosigmoiditis
Rx: Remicade @5mgs/kg/6wks; daily 75mgs 6MP, 4.8g Lialda, and 2X rowasa

😐 🚻 💩 😑 💩 😫 💩 😵 💩 💩 💩 💩

Post Edited (iPoop) : 7/25/2017 8:00:16 AM (GMT-6)


Posted By : DBwithUC - 7/25/2017 9:11 AM
as long as my co-pay card works I won't try, but this is good to know
11/08: ischemic colitis and scope perf colon. 12cm colon/ileocecal resected. IV antib:sepsis.
01/10: Dx: Mod. UC pancolitis. Rx: Lialda 3x.
02/11: Major flare w/antib:sinus. Rx: 40mg Pred taper. 6mp.
07/11: Histol remiss rt/trans; worse sigmoid. Rx: Rowasa & hydrocort
---
Curr: 1-2 soft-formed stool, no urgency: Lialda 2x, NO PRED, probiotics, Vit-D/C

Posted By : Spo307 - 8/14/2017 6:36 AM
I have been on generic lialda for about a week and a half and now have mucus and blood and abdominal discomfort I have always used lialda for the past 14 years so now I will be calling the doctor to get a RX for Lialda

Posted By : carol19 - 8/17/2017 8:43 AM
Spo307 said...
I have been on generic lialda for about a week and a half and now have mucus and blood and abdominal discomfort used lialda for the past 14 years so now I will be calling the doctor to get a RX for Lialda


I saw your post from 8/14 and I feel so much better. I am newly diagnosed with colitis and took lialda for one month. It wasworking. I got a refill but they gave me the generic and have the same symptoms you described. I just called my doctor. Thank you! ( I couldn't figure out what was going on.) Thank you again! smile smile smile smile

Posted By : Jehayland - 8/20/2017 11:20 AM
They just switched me to generic. I'm going to give it some time to see how it works. I was having trouble with Asacol when I was on it a few years ago, Lialda worked much better. The coating on the generic tastes odd and gets sticky when wet (Lialda did not).

I will see how it goes but may also need to request the name brand specifically.

Posted By : momto2boys - 8/21/2017 6:00 AM
My insurance copay is the same for either lialda or generic, so I am sticking to brand name since I use the co-pay assist card and end up paying only $10 for Lialda and would pay $60 for the generic. Doesn't make financial sense for me to bother trying the generic now.
42 yrs old diagnosed with proctosigmoiditis 6/13/13
meds- 4 Lialda + sfRowasa every other night- supplements: probiotics (1 VSL3 cap, 1 culturelle and 1 reuteri) 1 gram krill Oil, 1TBSP p. seed powder, 2 g curcumin. Allegra for seasonal allergies as needed. Allergic to sulfites. Currently gluten/dairy free (except yogurt) and eating lots of RS.

Posted By : turtlepower - 8/21/2017 2:05 PM
I was recently switched to generic as well. No real side effects yet, but had a scare last weekend with a super stiff neck - barely could move it and difficulty swallowing.

Went away after 2-3 days.

Posted By : TRIINA - 8/22/2017 7:10 PM
I am in the same boat. I have high deductible insurance so recently changed from Lialda to sulfaslazine but after taking it for two weeks I broke out in hives. So I found out I have a sulfa allergy... great. With lialda I had the savings card but be aware and read fine print, that it's only $10 for the first 3 refills then they only take $120 off so it's still almost $400. Sulfaslazine was only $16. I'm hoping that mesalamine works out. It's $120 but sill better than $400

Posted By : poopme - 8/28/2017 3:09 PM
Hi All,

Good to see this thread. I too was kicked off Lialda for Zydus's generic version recently and I also noticed that the earth red coating dissolves in water. Also never noticed with Lialda.

Please post if you notice any differences attributable to the generic so we keep each other informed... I will as well.

Thanks!

Posted By : iPoop - 9/1/2017 7:01 AM
I just got switched to the generic-lialda. The retail price for a 3-month supply of generic-lialda is still $3,635.99 at my RiteAid Pharmacy is $3,635.99 (or $1,211.99 for just a 30-day supply of 120 tablets). And here I thought generics were supposed to be cheaper than brand named drugs are, savings is less than $20 :-P
Moderator Ulcerative Colitis
John
, 39, UC Proctosigmoiditis
Rx: Remicade @5mgs/kg/6wks; daily 75mgs 6MP, 4.8g generic-Lialda, and rowasa

Invisible Illness: If I looked as bad as I feel then I'd scare your children!

Posted By : tap - 9/3/2017 4:40 AM
I went to refill my Lialda yesterday at the CVS/Caremark site as usual for the 90 day supply and they wanted to charge me $1225.26 with my insurance plan not covering any of the cost.

My previous purchase had it costing $1,531.57 with my insurance picking up $1,378.41 and with me picking up $153.16.

I emailed CVS/Caremark and they described how I could purchase the Zydus generic (NDC: 68382071119). Drum roll...

It has a cost of $2,365.60 with my insurance picking up $2,129.04 and with me picking up $236.56.

***!

Posted By : Lgreco - 9/9/2017 5:19 PM
I was switched today after being on Lialda for UC for a relatively consistent 7 years. Has anyone had a GOOD experience with the new generic?

Posted By : Lgreco - 9/9/2017 5:23 PM
Celeriac said...
My pharmacy automatically applies a manufacturer coupon for my Lialda and I pay $10 / month. Might be something to look into/ask about (if you're in the states)


I was surprised when I was rung up for $20 for the generic. I'm going to ask my GI for a new Lialda script, because these posts are worrying me. And Lialda is cheaper for me.

Posted By : tap - 9/10/2017 5:29 AM
tap said...
It has a cost of $2,365.60 with my insurance picking up $2,129.04 and with me picking up $236.56.

I checked into this some more and CVS/Caremark was quoting a price for 360 pills for 90 days instead of my prescription requirement of 180 pills for 90 days.

I guess that means that the cost would be $1182.80 with my insurance picking up $1064.52 and with me picking up $118.28.
49 - male - Diagnosed with pancolitis in 1998
Status: 2 stools a day
Vitamin D3 - 10000 IU 2-3 times per week (Status: 50 ng/ML);
Lialda - 2400mg 1 time per day
Perfect Health Diet

Posted By : Rensi - 9/10/2017 6:42 AM
Spo307 said...
I have been on generic lialda for about a week and a half and now have mucus and blood and abdominal discomfort I have always used lialda for the past 14 years so now I will be calling the doctor to get a RX for Lialda



I have been on it for about a month and my symptoms are coming back too, no blood but everything else has started again!

Posted By : iPoop - 9/10/2017 8:57 AM
No issues, for me at least, on generic lialda.
Moderator Ulcerative Colitis
John
, 39, UC Proctosigmoiditis
Rx: Remicade @5mgs/kg/6wks; daily 75mgs 6MP, 4.8g generic-Lialda, and rowasa

Panic-Poop: You are sure you're okay to leave, sit in your car and anxiety takes over, you start trembling and hear gurgling sounds, so run back into the house and poop like crazy. It's the reason I'm chronically-late >_<

Posted By : Coaches Wife - 9/13/2017 11:04 AM
Celeriac said...
My pharmacy automatically applies a manufacturer coupon for my Lialda and I pay $10 / month. Might be something to look into/ask about (if you're in the states)


How do you get the manufacturer coupon? I went on the Lialda website to see about getting some assistance and it said that if you are on Medicare/Medicaid you don't qualify for it due to it being covered by the insurance. BUT it is not covered by the insurance.

Any suggestions??

Posted By : iPoop - 9/13/2017 11:15 AM
I'd contact Shire Patient Assistance, and explain your situation.

about Shire Cares benefits and eligibility, please call 1-888-CARES-55 (1-888-227-3755), or email ShireCares@shire.com.

Shire Cares is available from Monday through Friday from 8 AM to 8 PM Eastern Time, except holidays.

Posted By : Coaches Wife - 9/13/2017 11:57 AM
iPoop said...
I'd contact Shire Patient Assistance, and explain your situation.

about Shire Cares benefits and eligibility, please call 1-888-CARES-55 (1-888-227-3755), or email ShireCares@shire.com.

Shire Cares is available from Monday through Friday from 8 AM to 8 PM Eastern Time, except holidays.


THANK YOU!! I will give that a try!

Posted By : hateuc - 9/13/2017 12:09 PM
Interesting thread. They tried to pass off generic on me too but fortunately I opened the bag there...noticed it and told them no thanks. I have the savings card so as long as that works, I will stick with what I am doing. Please do keep us all posted if anyone tries the generic.
B

Posted By : MarjieKay - 9/13/2017 12:14 PM
The enemas I use are generic and seem to have been fine for me.
F, 51
2008 colitis, 2016 chronic UC, 2017 quiescent UC
Current pharms: Pentasa 3g day, mesalamine enema (1 x per wk)
Anti-inflammatory diet :IBD-AID from U of Mass

Extras:
Advanced gut health probiotics, Primadophilis Reuteri, water & milk kefir
Digestive enzymes (big protein meals only now), Psyllium seed powder, Ginger Tea
Vitamins D, C & K, fish oil, cal/mag

Posted By : hateuc - 9/13/2017 6:04 PM
I agree, the generic enemas work for me!!
B
UC diagnosed in 2010 but had prob. in 2009
2 Lialda/day Rowasa nightly, periodic anucort supp, Cortifoam as needed(needed more than I would like)
VSL#3, slippery elm
Metamucil capsules
Trying Gluten free (why not!)

Posted By : Lgreco - 9/18/2017 8:51 PM
How is everyone doing on generic?

Posted By : iPoop - 9/19/2017 6:20 AM
Good, no issues.
Moderator Ulcerative Colitis
John
, 39, UC Proctosigmoiditis
Rx: Remicade @5mgs/kg/6wks; daily 75mgs 6MP, 4.8g generic-Lialda, and rowasa

Must've been a barking-spider!

Posted By : UCdee - 9/21/2017 6:35 AM
Having bad reaction to generic- just taking it for 3 days. I'm calling doc today and going back to Lialda. Glad to see this post, I really didn't know what happened! Back to urgent watery b/ms last two days.

Posted By : JewelsOK - 9/24/2017 6:11 PM
Anymore updates? My son just started it this past week, but is slowly switching over by taking 3 Lialda & 1 generic for a week, then going to do 2 & 2 for a while, then 1 Lialda and 3 generic, etc. until his supply of name brand runs out.

So far so good, but it's early!
Julie

Mom of Son 26 UC dx at age 10, Lialda x3, Azathioprine 175 mg, Iron, Protein Supplements.

Daughter 18 UC dx at age 8, Colazal x6, 6MP 25/37.5 mg, Prozac, Florastor, Culturelle, Iron, Vit/Min.

Posted By : turtlepower - 9/25/2017 7:41 AM
I was fighting a mini flare on Saturday, but I do not attribute it to the generic. It was a super hot day (Which always has the potential to give me problems) and made the mistake of having grapefruit juice. D'oh!

Other than that, no real problems. *Knocking on the biggest piece of lumber I can find*

Posted By : Bigwill63 - 10/2/2017 9:12 AM
The generic lialda seems to be hurting my remission as well. Starting to get more urgency and inflammation going on. I was down to 2 a day for the last year along with biweekly enemas and all was good. Switched about 4 weeks ago. Upping my dosage and hopefully will help. I called the pharmacy to get brand name and it looks like the perscription savings card is ending October 15th. Bummer

Posted By : iPoop - 10/2/2017 9:19 AM
The prescription savings card for lialda is good for one year at a time, call them (or request another online) to get another card for another year. There's no limits on how many years you can have a card! Some of us have had cards for many years!
Moderator Ulcerative Colitis
John
, 39, UC Proctosigmoiditis
Rx: Remicade @5mgs/kg/6wks; daily 75mgs 6MP, 4.8g generic-Lialda, and rowasa

That walk we do, due to post-public-restroom-embarassment, from our awful poop-spolsion in the bowl that flushing alone won't fully hide. Quiet, sly, and as near of a direct-path to the exit as possible...

Posted By : beanie15 - 10/8/2017 7:14 AM
I have also been switched to the generic and before starting, I wanted to see how everyone else was doing. I still have a couple of weeks worth of Lialda. Been on it without issue since 2009.
My 90 day supply was only $30 co-pay and when I picked up my script from CVS it was only $15. I didn't realize I was switched until I got home, thought my doc only renewed for 45 days as I'm due to see her soon.

Just started a mild flare. Fun how this disease just keeps us guessing!

I will post with results if I have any problems with the generic.

Posted By : Lgreco - 10/16/2017 11:19 AM
Now that the Lialda savings card is over, I'm afraid generic may be my only option moving forward. For the past week, I've been taking half generic, half Lialda to test it out. No noticeable difference besides more frequent BM, but I've also upped fiber in my diet.

Posted By : UCinGV - 10/16/2017 1:30 PM
My employer is trying to push everyone into HSA/HDHP plans and phasing out their PPO starting at the end of 2019. The big problem with this for me, of course, is buying Lialda out of pocket. Currently my PPO is charging me $40 and paying $1124. (I also found out I was switched to the generic without me noticing. Before three months ago I was paying $250 and insurance paid $1296.)

So, in anticipation of being pushed into an HSA plan, I started looking at these prices. Someone showed me this app called "GoodRX" where you can find the place with the cheapest prices. This app says that 180 pills of generic Lialda "Mesalamine DR" is $1100 at Costco (close to what I'm paying with my insurance company's mail order) and $463 at Walmart.

Can that be right? Is there that big of a difference in prices or is the drug at Walmart different?

Before I go down there and buy some, how can I be sure that any "generic Lialda" I am buying has the same delivery mechanism as brand name Lialda?

Is "Mesalamine DR" the official generic name for Lialda with the delivery mechanism of Lialda?

Posted By : iPoop - 10/16/2017 2:27 PM
Zydus Pharmaceuticals produces both generic-lialda and generic-asacohd.

www.zydususa.com/product-details/?id=307

www.zydususa.com/product-details/?id=216
Moderator Ulcerative Colitis
John
, 39, UC Proctosigmoiditis
Rx: Remicade @5mgs/kg/6wks; daily 75mgs 6MP, 4.8g generic-Lialda, and rowasa

Told my dentist I'd rather see him than my gasteroenteroligist. He said he'd take that as a compliment smile

Posted By : JohnnyUC - 10/17/2017 8:46 AM
I Switched to the generic 2 months ago. Blood and mucus came back. My GI asked if anything had changed and i told him i was taking the generic lialda. He said to switch back. have gone back to name brand and symptoms disappeared. there is supposed to be an allowable 1% difference in formula. so i am willing to pay the extra $20 for the name brand.

Posted By : Glasw55 - 10/17/2017 8:53 PM
Has anyone that has been on Lialda and in remission had success taking the generic brand? I can't afford to have a flare, last flare was horrific and caused me permanent damage to my spine due to side effects of Prednisone, and I don't want to go on Humira or any other serious drug.

Don't think that taking these drugs are without risk. I've been on Lialda for 4+ years and it has been keeping me stable, took Asacol before that and flared every year. The release system of Lialda differentiates how it works compared with Asacol. They are both Mesalamine but work completely different in how the medicastioj is released into your system.

Anyway, I'm very wary in having to go the generic route but if I stay on Lialda, it will cause me to eventually go broke. My insurance won't cover much of the cost now and Lialda stopped their co-pay program. This is really disheartening to say the least.

Posted By : iPoop - 10/18/2017 6:32 AM
I've been fine on Generic Lialda. Often switching between mesalamines is uneventful (and most pharmacists and doctors will say there's minimal difference), but some can have issues with it. There are no guarantees in life, you can certainly try it and switch back to the brandname if it becomes a necessity.

I think having an affordable medication is key as you're most likely to take it as recommended (and not take less of the brandnamed med and have adverse reactions as a consequence, say 3 pills a day instead of 4 or whatever).

There's several generics available that are mesalamine with delayed-release coatings. There's Mesalamine DR 800MG (generic Asacol HD) and Mesalamine DR 1200MG (generic Lialda).

Other generics that are a more complex molecule that is broken down to mesalamine and a byproduct by your gut bacteria. They're older medications but a lot more affordable than the above mentioned meds. The end result is the same, it's just not a MMX polymer that delivers the medication to the target location, rather gut bacteria cleave apart complex molecules to deliver mesalamine.
1.) Balsalazide disodium (generic of ColazalĀ®)
2.) Olsalazine (generic of DipentumĀ®)
3.) Sulfasalazine

One way or another, there is an affordable means to take a UC medication that will help you maintain your remission. Talk with your doctor about what is affordable and I am sure he/she can prescribe something that is cost effective. For example, Sulfasalazine is less than $100 a month without any insurance.

Cheers!
Moderator Ulcerative Colitis
John
, 39, UC Proctosigmoiditis
Rx: Remicade @5mgs/kg/6wks; daily 75mgs 6MP, 4.8g generic-Lialda, and rowasa

Told my dentist I'd rather see him than my gasteroenteroligist. He said he'd take that as a compliment smile

Post Edited (iPoop) : 10/18/2017 6:37:58 AM (GMT-6)


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