I'm sorry to hear that you're just about out of options. I was also reluctant to go on methotrexate, but for different reasons than you. I was worried about future children, although I've since decided that my family is complete, and I was also worried about interstitial lung disease, which mtx can contribute to. Once I made the decision, however, and went on mtx, I realized that it was a good decision. I will probably remain on mtx for a number of years (my mother took it for over 10 years and my father was on it for 15 years). It's a pretty safe drug. I'm not a drinker, but I would think that it is still ok to have a drink while on mtx once in a while. I probably wouldn't drink everyday on it, but I would think a few drinks per week would be acceptable. I guess this would still entail a major life changing decision for you, though.
As far as a liver biopsy is concerned, I was not aware that this is a standard requirement for mtx users. My mother never had one; my father never had one; and my rheumy has not even mentioned it. I thought you only had to have one if you start showing symptoms of liver problems?
Of course your concerns are valid. I'm sure that you will come to the right decision for you. I don't think it could hurt to check out the clinical trials in your area. What about some of the other biologics, like orencia, and something else that came out around the same time?
Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Aciphex, Ultracet, Zyrtec, Allavert-D, Zantac, Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan