Yes, I nearly died. The first reaction was big, but then they had me premedicate with benaryl and tylenol, and they gave me a streroid shot at the infusion room. However, I had a huge, terrible reaction a couple infusions after that. It's pretty common to have an allergy to Remicade--lots of people have had it. Don't go along with any premedication plan, I say! It's crazy talk.