Sorry to hear you are having a difficult time with the MTX, I have been on Enbrel less than 3 months and also take the MTX with it...I have not had any serious life threatening illnesses while on the Enbrel just a couple of bad colds where I have had to postpone an injection (like now). When I take it, it works for about
three days and then that is it so I will soon take it twice per week, but so far so good. Colds and such seem to last longer now with the Enbrel, and sores and such seem to take much longer to heal but other than that I can't think of anything. Hopefully someone else will be along to help.. Although if you are very suppressed by the MTX, I can understand your fear of the biologics.