I had a little fatigue after humira injections, but I only took humira for 3 months before switching to enbrel. Enbrel never had that effect on me--- in fact, I used to get a boost of energy from the enbrel. Not sure if it was the humira, or just the inflammation that was causing the fatigue--3 months was not long enough on humira. It took at least 6 months for me to get any relief on the enbrel.
Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Methotrexate, nexium, tramadol, nasonex,Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan, zyrtec, zegerid, aciphex