I agree, celebrex is just not strong enough on its own. I'm still on it, along with humira and mtx and am wondering whether I should now stop taking it. The biological agents really seem to work. I feel like a new woman on humira, I can run up stairs, no stiffness in the morning, all my swelling gone. My inflammatry factor went from 200 to 3 in a week! I'm afraid of the toxicity but the pain relief is sooo good, my life is so much better. If you have arthritis I think you have to weigh up quality of life vs toxicity all the time and try to minimise the effects with healthy living and added vitamins and exercise. Goodluck!