celebrex not working

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New Member

Date Joined Oct 2008
Total Posts : 7
   Posted 10/28/2008 5:39 AM (GMT -7)   
hi all, i have been on 400mg of celbrex for 7 days now and the swelling in my fingers is not going away. does this sound normal? i had hoped that it would relieve ALL the pain,swelling and stiffness, but it has not. or does it just take a long time to work?
i am nervous about taking the celebrex in the first place and would like to stop as soon as possible. anyone familiar with this drug?

Veteran Member

Date Joined Nov 2006
Total Posts : 1331
   Posted 10/28/2008 6:44 AM (GMT -7)   
I never noticed any difference on Celebrex, and that is when we moved on to Plaquenil and the MTX etc. I have tried it from time to time and all that I notice is an increase in my blood pressure.

Regular Member

Date Joined Oct 2008
Total Posts : 68
   Posted 10/28/2008 10:31 AM (GMT -7)   

I also tried celebrex and did not notice much difference in pain relief. I can not take any NSAIDS at all now, because I have developed ulcers from so many anti inflammatory medication.

I have had both hips and both knees replaced, 4 disc surgeries, and am going in for the rotator cuff in two weeks.

Regular Member

Date Joined Aug 2006
Total Posts : 81
   Posted 10/30/2008 5:16 PM (GMT -7)   
I was on Celebrex for a while and noticed absolutely no improvement whatsoever.  Tell your doctor and you will probably be moved up to something better and stronger.  As for Plaquenil, I had no improvement with that either and had the added cost and worry with eye doctor visits...

Arthritis (poss. RA) - Doc scripts: Enbrel 50 autoinjector, Methotrexate 5 pills/week, Folic acid. 

Veteran Member

Date Joined Sep 2008
Total Posts : 1670
   Posted 10/31/2008 8:32 PM (GMT -7)   
I agree, celebrex is just not strong enough on its own. I'm still on it, along with humira and mtx and am wondering whether I should now stop taking it. The biological agents really seem to work. I feel like a new woman on humira, I can run up stairs, no stiffness in the morning, all my swelling gone. My inflammatry factor went from 200 to 3 in a week! I'm afraid of the toxicity but the pain relief is sooo good, my life is so much better. If you have arthritis I think you have to weigh up quality of life vs toxicity all the time and try to minimise the effects with healthy living and added vitamins and exercise. Goodluck!

Regular Member

Date Joined Oct 2005
Total Posts : 315
   Posted 11/2/2008 8:39 AM (GMT -7)   
I have also tried Celebrex many times, but it does not seem to help me much either. Several years ago, I had tried Bextra (which is also a COX-2 inhibitor and similar to Celebrex)....the Bextra worked great for me! But just as it was really helping, it was pulled off the market. I did not notice any high blood pressure while on it, either. However, Celebrex did raise my blood pressure.

deb in indiana
Regular Member

Date Joined Aug 2005
Total Posts : 387
   Posted 11/2/2008 7:41 PM (GMT -7)   
I just got taken off of it the dr. up my pain medicine and said stop celebrex the vioxx did wonders for me till they pulled that one alsoDeb
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