I'm a new user (2 shots so far) of Humira. I haven't had any negative reactions, and any improvements so far have been subtle. I'm very hopeful about
the future with this drug, however. Like many people here, I was a MTX user until my liver enzymes got too high to continue.
Only you and your doctor can decide if the risks of Humira are worth the benefit. For me, it's working well. I wanted to add a thought on the risks associated with any of these drugs.
Personally, I ignore the laundry list of everything that could go wrong, and look at the actual events that occured during human testing. Inevitably, things go wrong. The important point, however, is to compare these events between the group that got the drug and the group that got the placebo. For example, in RA patients, 1.0% had vomitting as a side effect. That sounds bad, but then you see that 0.7% of patients receiving a placebo had vomitting. The difference is just 0.3%. In a trial that lasts many months, a lot of people will get sick to their stomach for lots of reasons. There are other examples, of course, where the difference between the drug and the placebo is much greater. The point is that you need to look at the difference between what patients taking the drug report and what patients taking the placebo report.
If you're switching from another drug like MTX, you can also look at the difference between negative events on MTX and Humira. For me, the risks of Humira look much lower than MTX.
That's probably a more complicated answer than you were looking for, but I find it helpful to try to understand what they learned in testing these drugs.