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New Member

Date Joined Feb 2009
Total Posts : 2
   Posted 2/19/2009 1:32 PM (GMT -7)   
Hi I am diagnosed with AS, and have been treating for the past year. First we tried sulphasizine (sp?) but I had to get off that because it made my WBC count so low I had to get an injection of Neupogen. I've been on Enbrel for about 8 or 9 months, the 50 mg click pen, and it has helped a lot. I mean I take vicoden and flexeril, too, but my flexibility, pain, and range of movement have definetely improved. Lately I've noticed the Enbrel is "puttering out" on me before it's time for the next injection. I take it on Saturday morning, and by Thursday afternoon, I'm hurting pretty bad... counting down the hours to Saturday morning. I discussed this with my Rheumy, and he suggested I try to split the dosage. Enbrel apparently comes in a 25 mg dose, and he suggested taking it 2x per week. Have any of you tried this? Also he said it doesn't come in the sure click pen... you actually have to draw it up in a syringe and inject it. Yuk. I was just looking for feedback and thoughts... he said he really didn't want to change me to Humira or Remicade because I have been doing so well on the Enbrel. So hopefully it may work better this way.

Veteran Member

Date Joined Nov 2006
Total Posts : 1331
   Posted 2/19/2009 3:49 PM (GMT -7)   

Yes, I have taken the Enbrel 25mg twice weekly and it did make a difference over taking it once per week.  While on Enbrel I had the same issue with it just not working through to the next dosage time.  Yes, it means injecting more often but you get used to it.


Good luck to you!

New Member

Date Joined Feb 2009
Total Posts : 2
   Posted 2/19/2009 5:13 PM (GMT -7)   
Thanks, hopefully it will work fir me too.

Regular Member

Date Joined Aug 2006
Total Posts : 81
   Posted 2/27/2009 11:32 AM (GMT -7)   
Keep in mind that Enbrel affects the immune system. Enbrel has a half-life of 60 hours which is roughly 2.5 days. My doctor says taking it twice a week keeps the immune sysem supressed more constantly than the once a week plan which allows the system to recover for a few days before the next injection.
Arthritis (poss. RA) - Doc scripts: Enbrel 50 autoinjector, Methotrexate 5 pills/week, Folic acid. 

Veteran Member

Date Joined Sep 2005
Total Posts : 1744
   Posted 2/27/2009 1:22 PM (GMT -7)   

I currently take enbrel, and I've experienced a similar effect as you.  My enbrel injection wears off a couple of days before my next injection.  My doctor gave me the option to up the dose to twice a week (50 mg, not 25 2x), but warned that it does pack a double whammy for the immune system and leaves you at a much higher risk for infection.  It's not worth the risk to me.  Some weeks are better than others and my injection lasts up to a day before the next injection.  On the bad weeks, I just take some tramadol and use lots of hot baths and heating pads.  Overall, though, I think enbrel is a great drug.


Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Methotrexate, nexium, tramadol, nasonex,Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan, zyrtec, zegerid, aciphex

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