Welcome to the HW forum
UGH the dreaded pred! Its one of those drugs that make you feel better and worse at the same time.
Ive been stuck on it for 6 years now and fully understand the side effects, although as you taper the side effects do too.
Does your husband have a Rheumatolgist? He should be seeing someone in regards to his RA.
Can he ask for another med, as pred is not really a maintenance med.
Maybe if he took one of the RA maintenance meds he could get off of the pred. Sometimes it takes a combination of the maintenance meds to find the right one for relief so make sure he persists till he finds the right one.
Not much help, but can sympathise with the mood thing - UGH.
Keep us posted on his progress.
Current meds: Methotrexate, Prednisone
Bowel Resection Sept. 07