I put off taking the Humira shots because of the fears of the terrible side effects that "could" happen. When the deformity and pain got so bad that I couldn't take it anymore I gave in and now wish I hadn't waited so long. I've been on the Humira now for two years and it has literally given me back my life. There is an increased risk of infection but I've learned to go to the doctor at the first sign of any problem. It's especially important to call your doctor right away if you have a fever or any sign of infection. I had to stop my shots a couple of times for a few weeks but so far haven't had any serious problems and most of the time I forget I even have arthritis.
As my rheumatologist says, "you can die from aspirin, if you're allergic to it". There are risks with any drug but it becomes a matter of quality of life. I first started on the Enbrel and did have a reaction at the injection site, they said most likely was from the preservatives in the drug. For a few weeks on the Humira the site would be a little red, hot and itchy but now I have no problems at all. It took a few months to kick in but then all of a sudden I was able to walk without limping. I can even get down on the floor and back up again, which was impossible before the Humira.
For me it's been a wonder drug.
Wish you the best. Keep trying and you'll find the right drug for you.
best of luck
psoriatic arthritis, peripheal artery disease