I have a general question. How long, usually, does it take to find a right combo of meds? I have had RA symptoms for about 12 years. I was evaluated in 2000, but the Dr only drew an RA foctor, which was negative, and he said, no, I didn't have it. At that time, I had no family history of RA. I attributed the pain and swelling to work (PA in a Pathology Lab...lots of dissection, all with hands, tools, and standing up). I am now 47. Last year, my Mom (age 65), and my uncle (age 53) were diagnosed in May and June, respectively. July came around, and guess what...I got the diagnosis too. There were already significant erosions in hands, feet, and shoulders. I was put on methotrexate, which we then increased in December. My liver enzymes spiked, so we went back down onthe MTX. I started Humira in November. There has been no improvement (actually, my fingers and toes are now "shifting"/subluxing. I was switched to Enbrel a month ago, and I still can't tell that I am getting any better. Is this common? Or do I just have a stubborn strain of RA?