Clinical trials on Remicade have documented that some people have a lessened or no response to Remicade when there has been a lapse in receiving the medication. Also, for some people, Remicade loses effectiveness over time. That is what happened to me. I took Remicade for 2.5 years. At first I was on the normal dose of 5mg per kilogram of weight every 6 weeks. Then they increased the dose to 7 mg/kg every 6 weeks. Then they shortened the interval to every 4.5-5 weeks.
Are you having lots of pain in your SI joints? I have has injections in my SI joints and got good pain relief. During acute flare-ups I have also been placed on short-term "bursts" of prednisone to get them under control. Is that an option for you?
Lastly, when Remicade stopped working for me, I went on to Humira, another anti-TNF med. That's didn't work for me. Then I was placed on Simponi, another anti-TNF. I have been taking it for 13 months and it has worked better than Remicade. Simponi is a once a month injection. Much easier than going for infusions. Has you doctor discussed changing you from Remicade to another medication? You might get better relief.
Moderator Crohn's Disease, IBS, and Osteoarthritis Forums
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, pulmonary hypertension, degenerative disc disease, asthma, severe allergy and a host of other medical problems.