RA/PsA and Bone Pain

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Regular Member

Date Joined Jul 2010
Total Posts : 297
   Posted 7/28/2010 2:55 PM (GMT -7)   
Presented with _*severe*_ back pain for three months, only thing that controls it is 400+mg of Tramadol HCl per day.

Blood tests, XRay, Full body MRIs, full physical checkup (by multiple doctors) and everything appears to be normal apart tenderness when pressed at certain points on spine and abdominals.

Now the doctor says VERY rarely MTX can result in bone pain, and he has seen in twice in his career, but never in the back - has anyone else experienced or heard of bone pain caused by MTX. Does not feel arthritic in nature, a very vague throbbing which slowly spreads through to my abs and groin over the course of days, unless treated aggressively with tramadol, and would ideally like to move onto hydrocodone as I'm slightly over the maximum dose!

Also taking 25mg MTX & 50mg Etancercept/Enbrel (Anti-TNF) via Sub-C injections.


Regular Member

Date Joined Jul 2010
Total Posts : 297
   Posted 7/29/2010 3:56 PM (GMT -7)   
Forgot to add the question - has anyone experienced strange pain when on MTX that they could not attribute to anything?

Or maybe on Etanercept (Enbrel)/Similar?

Thanks :/

Veteran Member

Date Joined Mar 2006
Total Posts : 1354
   Posted 7/29/2010 5:40 PM (GMT -7)   
Hi JayBespoke and welcome to HW and the RA forum smilewinkgrin
I have been on oral MTX for 6 years now and havent really experienced what you are describing.
Sometimes its hard to say whether its the disease causing the pain or the meds we take for it as who knows what the meds are capable of doing side effect wise.
Sorry Im not much help, just wanted to welcome you on board.
Crohn's Disease, Ankylosing Spondylitis
Current meds: Methotrexate, Humira
Bowel Resection Sept. 07
Forum Moderator - Rheumatoid Arthritis

Regular Member

Date Joined Jul 2010
Total Posts : 297
   Posted 7/29/2010 7:07 PM (GMT -7)   
Thanks very much Jo.

The doctor said he has only seen it twice in his career (and never in the back), and he was maybe 60. So extremely rare.

But after an MRI, XRAY and bloods, there was nothing left. Once you've eliminated the impossible, what remains, no matter how improbable, is the truth! - Sherlock Holmes ;)

It's either MTX, or referred pain from a Pancreatic or Stomach disease on top of my PsA. Occam's razor dictates MTX, and I really hope it is. I'm skipping a week and halving my dose. The pain is so bad without pain-killers that I can barely sleep an hour a night. Only 60mg+ of Codeine or Tramadol will even dampen it a little.

Thanks again for the welcome :) I'm always reading on forums, but never actually bothered to register & post anything until now.
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