I was disappointed, but for quite a while I was doing very well with MTX alone, then once I started Etanercept, i improved once again. I'm very up and down though, but that's the nature of PsA (more so than RA, which swings around less and is a little more predictable in that respect) but given that my symptoms could be explained by Fibromyalgia, I guess I can't blame the meds. (The more I read on it, the more convinced I become that it's exactly what's up!)
Having had numerous steroid shots, Sulfasalizine, MTX, and Etanercept, I've really exhausted all the different types of treatment - and my inflammation etc IS down, as are my inflammation markers, etc. What remains is exhaustion, and unexplainable pain. (And migraines, constipation, muscle twitches, insomnia, cognitive dysfunction.... all of which I previously assumed was part and parcel of arthritis and its treatment...)
i don't know about Humira, but my doctor told me Etanercept should make a difference within a day of the first injection. I'd say I felt a difference after about 2 weeks. Steroid injections used to make me feel like I'd had a full-body transplant or something... those were the days. I used to be apprehensive about injecting myself, but after doing it twice weekly for about 8 months now, I don't even flinch. I chose the syringe of Etanercept over the pen, because it gives me more control in the speed of injection (The pen does it rather quickly, and the pressure really hurts with Etanercept, it must have a low dispersion rate, so I inject it very slowly.) - The first time I injected it, supervised by a nurse, the words that came out of my mouth..... hah. It honestly gets easier though if you ever are in that position again, promise!
Depending on how my next year goes, I'll either study for a PhD in regenerative medicine/tissue engineering or in quantum physics. (Disparate fields, I know, but I've study nanotechnology for 3 years +, which involves both to a high level!) It just depends how good a grade I can get, I'm also trying to hold down 2 jobs, i've had to give one up (due to my back - nightclub security), and the other (which is full time at the moment, designing analysis software) is a daily struggle. I don't think I've made it in for a full 5 days a week in the last 2 months. Fortunately I'm self-employed and just invoice my client weekly, so they don't ask too many questions when they don't see me in my office on site.
Oh, and I need to find someone to pay for my PhD. Any offers? ;)
21, Male, England.
Dx: Psoriatic Arthritis, Chronic Back Pain, Dyspraxia
Rx: 25mg Methotrexate Sub-Cut Injection & 50mg Etanercept (Enbrel) Sub-Cut Injection
Oh, and plenty of Tramadol, Codeine, Diclofenac, Diphenhydramide, Paracetamol, and SCOTCH.