methotrexate and plaquenil

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Regular Member

Date Joined Jun 2010
Total Posts : 50
   Posted 12/15/2010 3:46 PM (GMT -7)   
hello hope everyone is well

just a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly
now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works.
i'm not expecting it to work over night but soon hopefully

i am still in so much pain everyday and hoping for some relieve soon.

also had to have an occupational health meeting today for my job as not worked for 6 months now and hoping they make me redundant as i can't work as a waitress with ra due to pain and flares in my opinion. (others may do) and i then can get benefits till i find a job i can do with the ra
(i am not doing this just for benefits, i hope people understand that)
RA since feb, incisitonal hernia awaiting sergery, asthma

peridislone 20mg, methotrexate 15mg, diclafenac 75mg, tramadol, co-codamol, folic acid, pumps


Veteran Member

Date Joined Dec 2007
Total Posts : 2113
   Posted 12/15/2010 4:12 PM (GMT -7)   
I have now been on Plaq for just over three years and MTX for just under three years.  The combination works well for me-though I also take a NSAID.
It took a while.  I started feeling better about a month after starting plaq-I was also on prednisone at the time-but couldn't get all the way well.  My Rheumy suggested MTX and told me it would be months before we knew for sure it would work.  However, in six weeks I was so much better I got off the prednisone.  Then a few months later had a flare and added NSAID.
Now I am pretty stable.  I occassionally will have some inflamation and add a medrol dose pack but that is few and far between.

Regular Member

Date Joined Jul 2010
Total Posts : 297
   Posted 12/15/2010 4:41 PM (GMT -7)   

MTX+Plaq can be a very effective method of treatment for RA, I guess because the MTX inhibits T-Cell activation and Plaq prevents messengers from telling T-cells to produce TNF - a combination which one imagines is going to be pretty effective - just make sure you have regular blood work with 25mg/w of MTX, it's on the high side, so I hope the side effects aren't too bad for you.

21, Male, England.
Dx: Psoriatic Arthritis, Fibromyalgia, Dyspraxia
Rx: 50mg Etanercept (Enbrel) Sub-Cut Injection, 50mg Amitriptyline

Oh, and plenty of Soma, Tramadol, Dihydrocodeine, Domperidone, Hydroxyzine, Acet- I think it might be quicker if I list the meds I don't take.

Regular Member

Date Joined Jun 2010
Total Posts : 50
   Posted 12/22/2010 7:02 AM (GMT -7)   
hi sorry not been on for a while, the side effects aren't to bad thank god, just horrible belly for a day each week.
i am on steroids and reducing now to 12.5 and then to 10 next month.
i hope i see some improvement soon as my knees are so bad i am on crutches and feel like a walking cripple. lol

thanks for getting back to me.
RA since feb, incisitonal hernia sergery 6weeks ago, asthma

peridislone 12.5mg, methotrexate 25mg, plaquenil 400mg, diclafenac 75mg, tramadol, co-codamol, folic acid, pumps


Veteran Member

Date Joined Sep 2008
Total Posts : 1670
   Posted 12/26/2010 5:22 PM (GMT -7)   
Hi Davina, I think it can take 3-4 months for the plaq to build up in your system, I wouldn't be winding down the pred too far until you notice some improvement from the plaq. If you're on crutches I wonder why your rheumy didn't throw in a biological?
Sounds as if you need something stronger?
But hey I'm not a doctor, hope you notice some improvement soon, golitho

Regular Member

Date Joined Jun 2010
Total Posts : 50
   Posted 12/28/2010 2:59 AM (GMT -7)   
hello golitho thanks for that, i'm on crutches due to my knees, had a mri 2wks ago and waiting results for the fluid sac's.
when i get results about what they are either to do with the ra or not then we are going to see about the next action.

RA since feb, incisitonal hernia sergery 6weeks ago, asthma

peridislone 12.5mg, methotrexate 25mg, plaquenil 400mg, diclafenac 75mg, tramadol, co-codamol, folic acid, pumps


Veteran Member

Date Joined Dec 2008
Total Posts : 2386
   Posted 12/28/2010 3:58 AM (GMT -7)   
Methotrexate takes 3 to 4 months to build into your system. Mods, this is off my personal experience, not medical training. I am currently on methotrexate and I am repeating what my oncologist told me.
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